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Studies on Development of Non-Cross Resistant Chemotherapy for Head and Neck Cancer

Research Project

Project/Area Number 01570961
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionHokkaide University

Principal Investigator

INUYAMA Yukio  Hokkaido University school of Medicine, Professor, 医学部, 教授 (70051480)

Co-Investigator(Kenkyū-buntansha) MAGUCHI Shiro  Hokkaido University Medical Hospital, Instructor, 医学部附属病院, 助手 (20199665)
TANAKA Kazuhito  School of Medicine, Keio University, Instructor, 医学部, 助手 (30179741)
ISHIKAWA Kazuo  Hokkaido University School of Medicine, Instructor, 医学部, 助手 (80212835)
SATOH Masaki  Hokkaido University Medical Hospital, Instructor, 医学部附属病院, 助手 (20215841)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsEstablishment of resistant cell lines / Growth inhibition test / Colony formation / Cisplatin / 5-fluorouracil / Methotrexate / Bleomycin / Non-cross resistant chemotherapy / 非交又耐性連続的化学療法 / 耐性細胞株樹立 / 相対的耐性度 / 非交叉耐性化学療法 / 5-Fluorouracil / Vincristine / Peplomycin
Research Abstract

(1) Basic research : Cell lines resistant to cisplatin (CDDP), 5-fluorouracil (5-FU), methotrexate (MTX) and bleomycin (BLM) were established from 2 kinds of head and neck cancer cell lines (KB cell HEp-2 cell). Drug sensitivity to these cell lines was examined in vitro by growth inhibition test and colony formation. Furthermore, these results were confirmed in vivo using only CDDP-resistant cell lines which were transplanted to nude mice. The results obtained were as follows : (1) CDDP-resistant cell lines were cross-resistant to MTX, BLM, mitomycin C(MMC), and peplomycin (PEP), but not so resistant to 5-FU, vincristine (VCR), and adriamycin (ADM). CDDP-resistant cell lines from KB cell were transplanted to nude mice. These tumors were quite resistant to CDDP, and less sensitive to MTX and ADM, but not resistant to 5-FU. (2)5-FU-resistant cell lines were cross-resistant to CDDP, MTX, PEP, and VCR, but not so resistant to BLM, MMC, and ADM (3) MTX-resistant cell lines were cross-resistant to BLM, VCR, and PEP, but not so resistant to CDDP, 5-FU, MMC, and ADM. (4) BLM-resistant cell lines were cross-resistant to CDDP and PEP, but not so resistant to 5-FU, MTX, MMC, VCR, and ADM.
(2) Clinical research : Six patients with recurrent head and neck cancer were treated with non-cross resistant sequential chemotherapy which consist of VMP therapy (vindesine, MTX-Leucovorin, PEP) and CF therapy (CDDP, 5-FU). Complete response was achieved in 1 and partial response in 2 out of the 6 patients with a response rate of 50%. The complete response rate was 17%. Toxic effects include bone marrow toxicity, nephrotoxicity, stomatitis, nausea and vomiting, but these toxicities were tolerable in most cases. Further studies were warranted.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 犬山 征夫ほか: "口腔癌,治療方針とその選択ー化学療法の立場から" JOHNS. 6. 199-205 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 犬山 征夫: "化学療法(薬物療法)による延命成績と長期生存例(続),頭頚部癌" 化学療法の領域. 6. 906-911 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 佐藤,公輝ほか: "頭頚部再発癌に対する非交叉性連続的化学療法の試み" 頭頚部腫瘍.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 犬山 征夫ほか: "頭頚部癌の遠隔転移に対する治療成績ー化学療法の立場からー" 頭頚部腫瘍.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 犬山 征夫ほか: "シスプラチン耐性癌への対応" JOHNS.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 犬山 征夫: "頭頚部癌における化学療法の効果と予後に関する検討" 耳鼻と臨床.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yukio Inuyama: "Prolongation of life and long-term survival cases in cancer chemotherapy-head and neck cancerー" Antibiotics & Chemotherapy. 6(5). 906 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yukio Inuyama: "Oral cancer-treatment policy and its selection" JOHNS. 6(2). 199 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yukio Inuyama: "Results of treatment for distant metastases, of head and neck, cancer-chemotherapy-" Head and Neck Cancer.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masaki Satoh: "Non-cross resistant sequential chemotherapy for recurrent head and neck cancer" Head and Neck Cancer.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yukio Inuyama: "A correlation between response to chemotherapy and prognosis for head and neck cancer" Otologia Fukuoka.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yukio Inuyama: "Diagnosis and treatment for head and neck cancer-management of cisplatin-resistant cancer-" JOHNS.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 犬山 征夫: "化学療法(薬物療法)による延命成績と長期生存例(続),頭頚部癌" 化学療法の領域. 6. 906-911 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐藤 公輝: "頭頚部再発癌に対する非交又性連続的化学療法の試み" 頭頚部腫瘍.

    • Related Report
      1990 Annual Research Report
  • [Publications] 犬山 征夫ほか: "頭頚部癌の遠隔転移に対する治療成績ー化学療法の立場からー" 頭頚部腫瘍.

    • Related Report
      1990 Annual Research Report
  • [Publications] 犬山 征夫ほか: "シスプラチン耐性癌への対応" JOHNS.

    • Related Report
      1990 Annual Research Report
  • [Publications] 犬山 征夫: "頭頚部癌における化学療法の効果と予後に関する検討" 耳鼻と臨床.

    • Related Report
      1990 Annual Research Report
  • [Publications] 犬山征夫: "(特集)口腔癌、治療方針とその選択1)化学療法の立場から" JOHNS.

    • Related Report
      1989 Annual Research Report
  • [Publications] 犬山征夫: "(特集)化学療法(薬物療法)による延命成績と長期生存例(続)、頭頸部癌" 化学療法の領域.

    • Related Report
      1989 Annual Research Report
  • [Publications] Inuyama,Y.: "XIV World Congress of Otorhinolaryngology-Head & Neck Surgery" Kugler & Ghedini Publications,

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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