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Study of Vestibular Maladaptation under Visual-vestibular Conflict

Research Project

Project/Area Number 01570962
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKeio University School of Medicine

Principal Investigator

TAKAHASHI Masahiro  Keio University School of Medicine, Associate Professor, 医学部, 助教授 (30051832)

Co-Investigator(Kenkyū-buntansha) 岡田 行弘  激応義塾大学, 医学部, 助手 (60185452)
斉藤 晶  慶応義塾大学, 医学部, 助手 (00186925)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
KeywordsMotion sickness / Reversing goggles / Horizonatal and vertical / locomotion / Equilibrium ataxia / Ataxia test battery / Susceptibility / Spatial orientation / 視前庭ミスマッチ / 歩行 / 水平および垂直 / 知覚ミスマッチ
Research Abstract

1. Walking while wearing horizontally reversing goggles induced apparent motion sickness, which severity was affected not only by individual susceptibility, but also by surrounding situations. In addition, onset of motion sickness was often accompanied with equilibrium ataxia.
2. Since vertically reversed vision, in contrast, did not evoke motion sickness, we must say that a mismatch between visual and vestibular inputs-alone does not evoke motion sickness, but a failure to detect spatial orientation which resulted from mismatched sensory inputs produced motion sickness.
3. To objectively show equilibrium ataxia when motion sickness occurred, we examined normal subjects with Graybiel's ataxia test battery, before putting on the goggles, during walking while wearing the goggles and after finishing walking. A significant decrease in the score was found in the case of horizontally reversed vision. However, the degree of equilibrium ataxia did not correlate with the severity of autonomic nervous symptoms.
4. Two patients with bilateral labyrinthine loss, one congenital, the other acquired, were examined in the same way. Although both patients similarly did not exhibit motion sickness symptoms, they showed quite different patterns of locomotion and equilibrium ataxia. Whereas a patient with congenital inner ear anomalies could walk well. even while wearing horizontally reversing goggles, the other patient. who lost labyrinthine functions due to Streptomycin intoxication presented moderate to severe ataxia under both situations, especially under wearing horizontally reversing goggles. Based on all these results, we devised, a new hypothesis which infers top-down regulation of the vestibular system called "Spatial Coordinates Hypothesis".

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] M.Takahashi,et al.: "Locomotion and motion sickness under horizontally and vertical reversed vision." Acta Otolaryngol Suppl. 481. 319-321 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takahashi,et al.: "Locomotion and motion sickness during horizontally and vertically reversed Vision." Aviat Space Environ Med. 62. 136-140 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takahashi,et al.: "Roles of haed,gaze and spatial orientation in the production of oscillopsia." J.Vestibular Res.1. 215-222 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takahashi,et al.: "Motion Sickness and equilibrium ataxia" Aviat Space Environ Med. 63. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 高橋 正紘,他: "生体内座標軸理論ー空間認知による固視,歩行の制御" 日耳鼻. 94. 161-169 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 斉藤 晶: "逆転プリズム装着下自由歩行による動揺病の研究" 慶応医学. 68. 763-772 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masahiro Takahashi et al: "Locomotion and motion sickness under horizontal and veritical reversal of vision." Acta Otolaryngol Suppl. 481. 319-321 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masahiro Takahashi et al: "Locomotion and motion sickness during horizontally and vertically reversed vision." Aviation Space Environment Med. 62. 136-140 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masahiro Takahashi et al: "Roles of head, gaze and spatial orientation in the production of oscillopsia." J Vestibular Res. 1. 215-222 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masahiro Takahashi et al: "Motion sickness and equilibrium ataxia." Aviation Space Environment Med. 62. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takahashi,et al.: "Roles of head gaze and spatial Orientation in the production of oscillopsia" J Vestibular Res. 1. 215-222 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takahashi,et al.: "Motion sickness and equilibrium ataxia" Aviat Space Environ Med. 63. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 斉藤 晶: "逆転プリズム装着下自由歩行による動揺病の研究" 慶応医学. 68. 763-772 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takahashi,et al.: "Locomotion and motion sickmss during horizontally and vevtically reversed vision" Aviation Space Environ Med. 62. 136-140 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takahashi,et al.: "Roles of head,gaza and spatial orientation in the production of oscillopsia" J Vestibular Res. 1. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 正紘 他: "生体内座標軸理論ー空間認知による固視、歩行の制御ー" 日耳鼻. 94. 161-169 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 斉藤 晶、高橋 正紘 他: "視野逆転プリズムによる動揺病の研究(第一報)" 日耳鼻. 94. 198-202 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takahashi,et al.: "Locomotion and motion sickness during horizontally and vertically reversed vision" Aviation,Space and Environmental Medicine. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Takahashi,et al.: "Head stability and gaze during vertical whole-body oscillations" Annals of Otology,Rhinology and Laryngology. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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