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Studies on the Relationship Between Salivary Proline-Rich Protein Polymorphisms and the DNA Loci.

Research Project

Project/Area Number 01571029
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTokyo Dental College

Principal Investigator

MINAGUCHI Kiyoshi  Tokyo Dental College, Dept of Forensic Odontology, Associate Professor, 歯学部, 助教授 (00133380)

Co-Investigator(Kenkyū-buntansha) SHINTANI Masuro  Tokyo Dental College, Dept. of Forensic Odontology, Research Associate, 歯学部, 助手 (60171071)
HANAOKA Yoichi  Tokyo Dental College, Dept. of Forensic Odontology, Assistant Professor, 歯学部, 講師 (30180912)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
KeywordsProline-rich Protein / Salivary Protein / Genetic Polymorophisms / PRB Loci / Basic PRP / 遺伝子多型
Research Abstract

1. Four kinds of slow-migrating Gl proteins (Gl4J, 5, 6, 7) were purified and amino acid compositions were analyzed. All the proteins were proved to be the same kinds of Gl protein.
2. Under collaborative research with Dr. Azen, new variant of Gl protein (Gl8) was found. A previous study of this variant protein misidentified it as Pa2 and was a products of PRH1 locus. The other PRB3 allele in this individual was a null.
3. Slow-migrating Gl variants were examined in Chinese, Malays, Indians and Filipinos. These variant alleles were restricted to Mongoloids, and each allele was biased within Asian populations. Gl4 observed in whites was different from our slow-migrating Gl. In addition, new allele (Gl10) was found in Filipinos, which leads to the existence of 12 alleles in PRB3 locus.
4. Assuming that basic PRPs were produced from 4 loci, PmF, PmS, Ps, Gl, Pmo1, Pmo2, P3 proteins were classified through family studies into 4 groups, that is, PmF/PmS/Pmo1, Gl, Ps/Pmo2 and P3.
We would like to continue to establish the relationships between salivary basic PRPs and DNA loci. PRP Loci are highly polymorphic and will be useful for personal identification in forensic medicine and anthropological studies.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Azen,E.A et.al.: "Alleles at the PRB3 locus coding for a disulfideーbonded human salivary prolineーrich glycoprotein(Gl8) and a nullin an Ashkenazi Jew." Amer.J.Hum.Genet. 47. 686-697 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 水口 清: "唾液プロリンリッチプロテインの個人的変異" 歯科学報. 90. 1183-1193 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Azen, E. A., Minaguchi, K., Latreille, P. and Kim, H. S.: "Allese at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl8) and a null in an Ashkenazi Jew." Amer. J. Hum. Genet. 47. 686-697 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Minaguchi K.: "Salivary proline-rich protein polymorphisms." Shikwa Gakuho. 90. 1183-1196 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Azen,E.A.et.al.: "Alleles at the PRB3 locus coding for a disulfideーbonded human salivary prolineーrich glycoprotein(Gl8) and a null in an Ashkenazi Jew." Amer,J,Hum,Genet.47. 686-697 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 水口 清: "唾液プロリンリッチプロテインの個人的変異" 歯科学報. 90. 1183-1196 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Azen,E.A.et al.: "Alleles at the PRB3 locus coding for a disulfide bonded human salivay proline-rich glycoprptein(G1 8)and a null in an Ashkenazi Jew." Am.J.Hum.Genet.

    • Related Report
      1989 Annual Research Report
  • [Publications] 水口清: "唾液蛋白の遺伝標識に関する研究-とくにプロリンリッチプロテイン(PRP)を中心として-" 歯科学報. 89. 1735 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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