| Project/Area Number |
01571043
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KINOSHITA Masahiko Okayama University, Dental School, Assistant Professor, 歯学部附属病院, 講師 (80161537)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Hiroyuki Okayama Univ., Dent. Sch. Assistant, 歯学部, 助手 (90205609)
SHIMIZU Hideki Okayama Univ., Dent. Sch. Assistant, 歯学部, 助手 (70170983)
NOMURA Yoshio Okayama Univ., Dent. Sch. Associate Professor, 歯学部, 助教授 (50107075)
MURAYAMA Yoji Okayama Univ., Dent. Sch. Professor, 歯学部, 教授 (50029972)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Periodontal ligament cells / Growth factor / DNA synthesis / Collagen synthesis / Alkaline phosphatase / Prostaglandins / アルカリフォスファタ-ゼ活性 / 歯根膜線維芽細胞 / ペプチド性成長因子 / 歯周組織の再生 |
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| Research Abstract |
The effects of 5 kinds of growth factors (PDGF, b-FGF, INS, EGF and TGF) on the functions of Perio Dontal Ligament (PDL) cells were widely examined. The DNA synthetic activity was increased 2-3 fold by each growth factor. Furthermore, DNA synthetic activity was significantly enhanced by the combination of FGF and INS, FGF and TGF, EGF and INS, and FGF and TGF as compared with single administration of each growth factor.
Collagen synthetic activity was significantly enhanced by INS and TGF, while it was inhibited by EGF. TGF is the only growth factor that enhanced Alkaline phosphatase activity among these five growth factors.
These results suggests that TGF may strongly enhances functions of PDL cells.
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