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Effects of immunoglobulins on human dentinal caries

Research Project

Project/Area Number 01571050
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionKagoshima University

Principal Investigator

KAWAGOE Masataka  Kagoshima Univ., Dental Sch., Professor, 歯学部, 教授 (40028741)

Co-Investigator(Kenkyū-buntansha) MINEMOTO Katashi  Kagoshima Univ., Dental Sch., Research Associate, 歯学部, 助手 (80200096)
IWAMOTO Yuko  Kagoshima Univ., Dental Hospital, Research Associate, 歯学部附属病院, 助手 (10191454)
NAGAOKA Shigetaka  Kagoshima Univ., Dental Sch., Associate Professor, 歯学部, 助教授 (10155913)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
KeywordsDentinal caries / Immunoglobulins / Dentinal tubules / Immunohistochemistry / Pulpitis / 細菌染色
Research Abstract

Dental caries is the result of a bacterial infection which triggers the hutnoral immune response of antibody production. These antibody react with bacterial antigens within the carious lesion. We have sought to identify the immunoglobulins in human dentinal caries, and to determine their class, their capacity for penetrating into carious lesions. The immunoglobulin associated with advanced human dentinal caries may be pupal in origin, as it was mostly located between the pulp and the carious lesion of the vital teeth. The most frequent deposits were of IgG followed by IgA and IgM. sIgA was most frequently found in plaque, but was also present in the soft part of the lesions.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 長岡 成孝: "象牙質う蝕の進行と防御に関する免疫組織化学的研究" 日本歯科医学会誌. 10. 60-66 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nagaoka.S.et.al.: "Bacterial infvasion into dentinal tubules of huan vital and non-vital teeth" J.Dent.Res.(1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nagaoka, S.: "Immunohistochemical studies on development and defense mechanisms of dentinal caries" JJDS. 10. 61-66 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nagaoka, S.: "Miyazaki, M., Kawagoe, M., : Bacterial invasion into dentinal tubules of human vital and non vital teeth." J. Dent. Res.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 長岡 成孝: "象牙質う蝕の進行と防御に関する免疫組織化学的研究" 日本歯科医学会誌. 10. 60-66 (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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