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Immunohistochemical Study of Age-dependent Changes in the Gingival Tissue

Research Project

Project/Area Number 01571069
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 補綴理工系歯学
Research InstitutionKyushu University

Principal Investigator

SAKAI Takako  Kyushu Univ., Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (60128022)

Co-Investigator(Kenkyū-buntansha) KAWANO Keiichi  Kyushyu Univ., Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (10136492)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1990: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1989: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsAging change / Periodontal tissue / Type I and type III collagens / Fibronectin / コラ-ゲン / 加齢
Research Abstract

Immunofluorescent and immunoelectron microscopic studies of age-dependent changes of the periodontal tissues were performed in the lower first molars of mice ranging in age from one week to eighty weeks after birth. The alveolar bone which was completed by 20 weeks, was gradually decreased in amount and its surface bordered upon the periodontal ligament became irregular resulting in wavy appearance. A space which was occupied by the periodontal ligament decreased in width with aging, probably because of deposition of newly formed cementum on the surface of the root. In addition, cells in the periodontal ligament and in the gingival tissue also decreased in number with aging.
The typeI and type Ill collagens, and fibronectin were distributed in close association with the fibers of the periodontal tissue and the gingival tissue. TypeIIl collagen was intensely stained in association with the fiber bundles of the periodontal ligament being close to the alveolar bone of mice ranging in age from 2 to 20 weeks after birth. This fact indicates that an active syntheses of type III collagen occurred in this region. In mice of after 30 weeks postpartum, the junctional epithelium proliferated and migrated down to the apical side along the cementum. The fibronectin was strongly stained on the external basement membrane of migrating junctional epithelium. This finding suggests that the fibronectin played an important role in the proliferation and migration of the junctional epithelium.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 坂井 貴子: "マウス歯根膜の加齢的変化ー形態学的および螢光抗体法による観察ー" 日本補綴歯科学会雑誌. 35. 794-803 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takako Sakai: "Age-dependent Changes in the Periodontal Ligament of Mice-Morphological and Immunofluorescent Studies-" J. Jpn. Prosthodont.35-4. 794-803 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 坂井 貴子: "マウス歯根膜の加齢的変化ー形態学的および螢光抗体法による観察ー" 日本補綴歯科学会雑誌.

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Kawano: "The Chemistry and Biology of Mineralized Tissues M.J.Glimcher and J.B.Lian eds." Gordon and Breach Science Publishers, 967 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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