| Research Abstract |
The effects of some cerebral metabolic activators, which may improve disorders of motor function with age, on the locomotor activity, general behavior, rotarod performance and spinal reflex of the cerebrovascular, disordered rats were studied. The disordered rats were prepared by ligature of the left carotid artery of each aged (26-30 months old) and jurenile (8-9 weeks old) rats. Simulataneous recording of left lumbar roots (L_5) was undertaken as previously.
These spinal reflexes were examined on the 7 th days after the ligation. The coordinated motor activities were measured on the days after the ligation using the rotarod test.
Meclofenoxate add chlorpromazine administered by the i. v. route. Although no difference was observed in either the activity of M. S. R. or the duration of M. S. R. in each individual group on the 7 th days after the ligation, the latter of the aged rats was longer than that of the young rats. The neonatal activities of M. S. R. in the unligated group were between two and five fold higher than in the ligated group for both and young rats.
These differences were more pronounced in the aged rats. The drugs were tested seemed to improve the ligatureーreduced M. S. R. activities in both the aged and young rats.
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