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Development of the Shrew (Suncus Murinus) Lines with Robertsonean Fusions Originating from a Wild Population in Sri Lanka

Research Project

Project/Area Number 01580042
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionThe Research Institute of Environmental Medicine, Nagoya University

Principal Investigator

ODA Senーichi  The Research Institute of Environmental Medicine, Nagoya University, Assistant Professor, 環境医学研究所, 助手 (60023660)

Co-Investigator(Kenkyū-buntansha) NAMIKAWA Takao  School of Agriculture, Nagoya University, Associate Professor, 農学部, 助教授 (70111838)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsSuncus murinus / Chromosome / Robertsonean fusion / Development of line / Laboratory animal / Insectivore / 異数染色体
Research Abstract

The results of chromosomal analysis in this study indicate that the laboratory shrew lines can be divided into two types on the basis of chromosome number : the 2N=30 type and the 2N=40 type, representing the smallest and largest respectively, of numbers of chromosomes reported in this species thus far. The 2N=30 type is only found in the SRI line originating from a wild population on the west coast of Sri Lanka. However, the wild shrews caught on the east coast of Sri Lanka have been reported to have 2N=32. These facts provide evidence of chromosomal polymorphism within the wild population of shrews in Sri Lanka. On the other hand, the 2N=40 type is composed of the NAGand OKI lines originating from wild populations in Japan as well as the BAN line from Bangladesh. Matings between SRI (2N=30) and Japanese (2N=40) shrews demonstrated that their Fl, F2 and reciprocal backcross progeny were readily produced. The following chromosome numbers were observed in the hybrids : 2N=35 in Fl shrews, 2N=33 to 2N=38 in F2 shrews and 2N=30 to 2N=38 in reciprocal backcrosses. All the hybrids had the same total of 48 autosomearms. Those Robertsonean lines were developed from them. 9 pairs of metacentric chromosomes, one pair of submetacentric chromosomes and 4 pairs of small acrocentric chromosomes. Furthermore, the metacentric chromosomes could be easily subdivided in to 2 groups : 5 pairsof large metacentric chromosomes and 4 pairs of small metacentric chromosomes. The large metacentric chromosomes which were not found in the 2N=40 type, are believed to have been formed via Robertsonean fusions among 10 pairs of large acrocentric chromosomes seen in the 2N=40 karyotype. We believe that the SRI shrew, as well as the Robertsonean fusion strain mouse, is a useful laboratory animal for chromosome studies.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Ishikawa,A.et al: "Development of a laboratory line (SRI line) derived from the wild house musk shrew,suncus murinus,indigeous to Sri Lanka." Experimental Animals. 38. 231-237 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oda,S.et alI: "Lethal mutations with chromosomal inversions in In(15)21RK,In(4)28RK,and In(4)32RK mice." Teratology. 40. 670-671 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Miura,Y.et al: "Fatty acid hydroxylase system in the Japanese harvest mouse,Micromys mmutus." Lipids. 25. 78-81 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oda,S.: "Nonーteratogenic effect of maternal oral administration of retinal palmitate in the house musk shrew,Suncus murines." Environmental Medicine. 34. 173-176 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oda,S.et al: "The house musk shrew:A new animal model for hereditary sucrase deficiency" Sciences et Techniques Animaux de Laboratoire. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ishikawa et al: "Kinky coat,a new autosomal recessive mutation in the house musk shrew (Suncus murinus, Insectivora)" Journal of Heredity. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 織田 銑一 (分担): "実験動物の生物学的特性デ-タ" ソフトサイエンス社, 656 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oda, S.et al: "Development of the unique strains of the house musk shrew,Suncus munnis" Carnegie Museum of Natural History, (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ISHIKAWA, A., AKADAMA, I., NAMIKAWA, T. and ODA, S.: "Development of a laboratory line (SRI line) derived from the wild house musk shrew, Suncus murinus, indigenous to Sri Lanka." Exp. Anim.38(3). 231-237 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ODA, S., Roderick, T. H. and KAMEYAMA, Y.: "Lethal mutations with chromosomal inversions in In(15)21Rk, In(4)28Rk, and In(4)32Rk mice" Teratology. 40. 670-671 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] MIURA, Y., HISAKI, H. and ODA, S.: "Fatty acid hydroxylase system in the Japanese harvest mouse" Micromys minutus.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ODA, S.: "Nonーteratogenic effect of maternal oral administration of retinol palmitate in the house musk shrew, Suncus murinus."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ODA, S., YOKOTA, K. and TAKESUE, N.: "The house musk shrew : A new animal model for hereditary sucrase deficiency" Sciences et Techniques Animaux de Laboratoire. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ISHIKAWA, A., HIRUNAGI, K., ODA, S., NAMIKAWA, T. and TOMITA, T.: "Kinky coat, a new autosomal recessive mutation in the house musk shrew (Suncus murinus, Insectivora)" J. hered.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ODA, S., ISHIKAWA, A. and NAMIKAWA, T: "Development of unique strains of the house musk shrew, Suncus murinus" The Biology of the Soricidae (Merritt, J., ed.), The Carnegie Museum of National History, Rector, Pennsylvania, USA, 1991.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] YOSHIKI, A., HANAZONO, M., ODA, S., WAKASUGI, N., SAKAKURA, T. and KUSAKABE, M.: "Developmental analysis of the eye lens obsolescence (Elo) gene in the mouse : Cell proliferation and Eloーgane expression in the aggregation chimera." Development. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ishikawa,A.et al: "Development of a laboratory line(SRI line)derived from the wild house musk shrew,suncus murinus,indigeous to sri Lanka." Experimental Animals. 38. 231-237 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Oda,S et al: "Lethal mutations with chromosomal inversions in In(15)21RK,In(4)28RK,and In(4)32RK mice." Teratology. 40. 670-671 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Miura,Y.et al: "Fatty acid hydroxyease system in the Japanese harvest mouse,Micromys munutus." Lipids. 25. 78-81 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Oda,S.: "Nonーteratogenic effect of maternal or al administratin of retinal palmitate in the house musk shrew,suncus murins." Environmental Medicine. 34. 173-176 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Oda,S.et al: "The house musk shrew:A new animal model for hereditary sucrase deficiency" Sciences et Techniques Animaux de Laboratoire. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ishikawa et al: "Kinky coat,a new autosomal recessive mutation in the house musk,shrew (suncus murinus,Insectivora)" Journal of Heredity. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 織田 銑一(分担): "実験動物の生物学的特性デ-タ" ソフトサイエンス社, 656 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Oda,S.et al: "Development of the unique strains of the house musk shrew,Suncus murinis" Carnegie museum of Natural History, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Oda,Sen-ichi: "Teratogenic susceptibility of the house musk shrew,suncus murinus,to all trans retinoic acid" Teratology. 38. 504 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 石川明: "ジャコウネズミ(Suncus murinus)実験室系統間における核型変異" 哺乳類科学. 28. 64 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 織田銑一: "スリランカ産ジャコウネズミSuncus murinusの特徴および飼育繁殖" 哺乳類科学. 28. 69 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 織田銑一: "長崎産およびスリランカ産野生スンクスを起原とするラインの育成と両ライン間の交配群の特徴" 第36回日本実験動物学会講演要旨集. 131 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ishikawa,Akira: "Development of a labaratory line(SRI line)derived from wild house musk shrew,Suncus murinus,indigenous to Sri Lanka" Experimental Animals. 28. 231-237 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 織田銑一: "スンクス(ジャコウネズミ)実験動物の生物学的特性デ-タ" ソフトサイエンス社(田嶋嘉雄監修), 1989 (pp586-596)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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