• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism and Persistency of HFRS Virus Infection in Laboratory Animals.

Research Project

Project/Area Number 01580043
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionResearch Institute for Microbial Diseases, Osaka University

Principal Investigator

DOHMAE Kayoko  Research Institute for Microbial Diseases, Osaka University Department of Science for Laboratory Animal Experimentation Instructor, 微生物病研究所, 助手 (80127266)

Co-Investigator(Kenkyū-buntansha) KURATA Takeshi  Department of Pathology, National Institute of Health Manager, 病理部, 部長 (50012779)
YAMANISHI Koichi  Research Institute for Microbial Diseases, Osaka University Department of Virolo, 微生物病研究所, 助教授 (10029811)
山之内 孝尚  大阪大学, 微生物病研究所学部, 教授 (40029765)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsHemorrhagic Fever with Renal Syndrome (HFRS) / Korean Hemorrhagic Fever (KHF) / Mouse / Rat / HFRS inactivated Vaccine B-1 Strain / 腎症候性出血熱HFRS / 不活性化ワクチンBー1
Research Abstract

The protective effect of antibodies could be transferred from immune dams to newborn. The effect of maternal antibody raised by immunization with HFRS vaccine on the protection of newborn rats and mice from infection by HFRS virus was examined. Antibody to HFRS virus was transferred from immune dams to their offspring prenatally as well as postnatally. In the sera of the newborn, IgG and IgA titer of maternal antibody were detected and reached a park around 1 week after birth, then declined and disappeared at about 14 weeks of age. After intraperitoneal challenge by B-1 or KHF virus. Death and infection of 1-day-old rats or mice from immune dams were prevented by the presence of maternal antibody. The protective effect of maternal antibody is limited only to saving the life of newborns and is not to prevent viral infection when titer of maternal antibody is low. Further persistent infection of HFRS virus was demonstrated by the existence of virus in the brain of old rats infected more than 3 years ago.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] M.Tamura, H.asada, K.Kondo, O.Tanisita, and K.Yamanishi: "Pathogenesis of Hantaan Virus in Mice." J.gen.Virol.70. 2897-2906 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Tamura, S.Ogino, T.Matsunga H.Asada, K.Kondo, K.Yamanishi and I.Kurata: "Experimental labyrinthitis in Rats Caused by Infecting with Virus Causing Homorrhagic Fever with Renal Syndrome(HFRS)." Acta Otolaryngol (Stockh). 108. 19-25 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H.Asada, K.Balachandra, H.Tamura, K.Kondo, and K.Yamanishi: "Crossーreactivc Immunity among Different Serotypes of Virus Causing Hacmorrhagic lever with Renal Syndrome." J. gen. Virol.70. 819-825 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 堂前 嘉代子: "腎症候性出血熱ウイルス、及び関連ウイルス、の新生仔マウス、新生仔ラットに対する病原性の比較検討" 和歌山医学. 40. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Tamura et al: "Pathogenesis of Hantaan Virus in Mice." J. gen. Virol.70. 2897-2906 (1899)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Tamura et al: "Experimental Labyrinthitis in Rats Caused by Infecting with virus Causing Hemorrhagic Fever with Renal Syndrome (HFRS)." Acta Otolaryngological (Stockh). 108. 19-25 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Asada et al: "Cross-reactive Immunity among Different Serotypes of virus Causing Hemorrhagic Fever with Renal Syndrome." J. gen. Virol. 70. 819-825 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Dohmae: "Comparative Studies on the Virulence of Hemorrhagic Fever with Renal Syndrome (HFRS) on Newborn Mice and Rats." Wakayamaigaku. 40. 1-13 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Tamura,H.asada,K.Kondo,O.Tanisita,and K.Yamanishi: "Pathogenesis of Hantaan Virus in Mice." J.gen.Virol.70. 2897-2906 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Tamura,S.Ogino,T.Matsunga H.Asada,K.Kondo,K.Yamanishi and I.Kurata: "Experimental Labyrinthitis in Rats Caused by Infecting with Virus Causing Hemorrhagic Fever with Renal Syndrome (HFRS)." Acta Otolaryngoi (Stockh). 108. 19-25 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Asada,K.Balachandra,H.Tamura,K.Kondo,and K.Yamanishi: "Crossーreactive Immunity among Different Serotypes of Virus Causing Haemorrhagic Fever with Renal Syndrome." J.gen.Virol.70. 819-825 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 堂前 嘉代子: "腎症候性出血熱ウイルス、及び関連ウイルス、の新生仔マウス、新生仔ラットに対する病原性の比較検討" 和歌山医学. 40. (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 堂前嘉代子: "腎症候群出血熱ウイルス、及び関連ウイルスの新生仔マウス、新生仔ラットに対する病原性の比較検討" 和歌山医学. 40. 1-13 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshio Mii,Y.Miyauchi,K.Hohnoki,H.Haruyama,M.Tsutsumi,K.Dohmae,T.Yamauchi…etc.: "Neural Crest Origin of Clear Cell Sarcoma of tenons and aponeuroses" Virchows Archiv A Pathol Anat. 51-60 (1989)

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi