| Project/Area Number |
01580065
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
家政学
|
|---|
| Research Institution | Nara Women's University |
|---|
Principal Investigator |
MIZUKAMI Taiko Nara Women's Univ., Faculty of Home Economic, Associate Professor, 家政学部, 助教授 (50031688)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA Ranko Nara Women's Univ., Faculty of Home Economics, Professor, 家政学部, 教授 (30031652)
|
|---|
| Project Period (FY) |
1989 – 1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
|---|
| Keywords | Pregnancy / L-methionine / Soy protein isolate / Estrogen / Free amino acids / 妊娠時のタンパク質栄養 / Metの補足効果 |
|---|
| Research Abstract |
Fetal death in the last few days of pregnancy or neonatal death were observed in tats fed diets of less than 35% Soy Protein Isolate (SPI) throughout pregnancy. Among the groups of rats fed 20% SPI, 30% SPI, 35% SPI, 40% SPI, 20% SPI+0.6% L-methionine (Met). 30% SPI+0.9% Met, 35% SPI+1.1% Met, and 40% SPI+1.2% Met, the last one showed decreased neonatal death and improved biological value.
Fetal growth and placental function were studied in rats on 19th and 20th day of pregnancy. Rats were fed a 10% purified whole egg protein (PEP) diet for control and a 20% SPI diet and a 20% SPI+0.6% Met diet. The food intake and body weight of the 20%SPI diet group decreased after 18th day of pregnancy.
Free amino acid concentration in serum and amniotic fluid of SPI diet groups showed higher value than those of PEP diet group. This suggested that abilities of active transport of free amino acids in the placentas of SPI diet groups were inferior to that of PEP diet group. Free fatty acid concentration in serum of SPI diet groups were lower and glucose concentration in serum of SPI diet groups were higher than those values in serum of PEP diet group. Estrogen in urine of SPI diet groups were higher than that of PEP diet group in 19th day of pregnancy.
These results showed that SPI intake induced changes of endocrine system in pregnant rats.
|
