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有機化学における複合系の高次制御

Research Project

Project/Area Number 01649007
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTokyo University of Science

Principal Investigator

向山 光昭  東京理科大学, 理学部, 教授 (60016003)

Co-Investigator(Kenkyū-buntansha) 伊藤 嘉彦  京都大学, 工学部, 教授 (40026018)
桑嶋 功  東京工業大学, 理学部, 教授 (50016086)
奈良坂 紘一  東京大学, 理学部, 教授 (50016151)
大野 雅二  東京大学, 薬学部, 教授 (00111550)
桜井 英樹  東北大学, 理学部, 教授 (70025873)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥80,900,000 (Direct Cost: ¥80,900,000)
Fiscal Year 1989: ¥80,900,000 (Direct Cost: ¥80,900,000)
Keywords複合系高次制御 / 複合系の構造化学的アプローチ / 複合系の反応論的アプローチ / 複合系の分子機能 / 複合系の反応試剤 / 複合系の反応設計 / 複合系の反応制御 / 有機合成化学
Research Abstract

有機化合物における特異な物性、反応性あるいは反応の選択性を、単分子的にあるいは直接反応に関与する分子間相互作用のレベルで理解するこれまでの捉え方に加えて、分子とそれを取り巻く環境を複合的に把握し、有機分子が示す種々の物理的および化学的現象を、有機、無機、生物など関連諸分野の研究者の参加のもとに、総合的な観点から解明することを目的として研究を行った。総括班は、各班における、1)複合系の構造化学的アプローチ、2)複合系の反応論的アプローチ、3)複合系の分子機能、4)複合系の反応試剤、5)複合系の反応設計、6)複合系の反応制御、などの研究を、総括班会議、班長会議を通じて、総合的に取りまとめ、推進した。
平成元年11月20、21の2日間、大阪において第1回の公開シンポジウムを開催し、全班員に加えて各大学、企業から73名の参加を得て盛大に行われた。本シンポジウムでは、各研究班の班長が、班会議での活発な討議をもとに、それぞれの班の研究計画について総合的な説明を行い、引き続き各班の計画班員および公募班員から、加納航治、村上幸人、細見彰、山本明夫、鳥居滋、奈良坂紘一、竜田邦明、山本嘉則、金岡祐一、光延旺洋、板井昭子、斉藤烈、大野雅二の各氏が、各自の研究計画および成果について報告し、熱心な討議が行われた。
また、全班員の研究成果について取りまとめた研究成果報告書を刊行し、関係各位に配布した。
次年度のシンポジウムとして、第2回を6月に東京で、第3回を12月に仙台で開催することに決定し、準備を開始した。

Report

(1 results)
  • 1989 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] S.Kobayashi: "Asymmetric Aldol Reaction of Silyl Enol Ethers with Aldehydes Promoted by the Combined Use of Chiral Diamine Coordinated Tin(II)Triflate and Tributyltin Fluoride," Chem.Lett.297-300 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Homma: "Convenient Synthesis of Disubstituted Cyclic Ethers. Synthesis of(-)-cis-Rose Oxide and(cis-6-Methyltetrahydropyran-2-y1)acetic Acid" Chem.Lett.893-896 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Effective Activation of Carbonyl and Related Compounds with Phosphonium Salts.The Aldol and Michael Reactions of Carbonyl Compounds with Silyl Nucleophiles and Alkyl Enol Ethers" Chem.Lett.993-996 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Efficient Activation of Acetals toward Nucleophiles by the Use of Transition Metal Salts.New Method for Cyanation of Acetals and Orthoester Derived from Aromatic and α,βーUnsaturated Carbonyl Comppounds with Trimethylsilyl Cyanide under Neutral Condition" Chem.Lett.997-1000 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Perfect Stereochemical Control in the Synthesis of synーαーMethylーβーhydroxy Thioesters by Asmmetric Aldol Reaction of Silyl Enol Ethers with Aldehydes" Chem.Lett.1001-1004 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "[1,2ーBenzenediolato(2ー)ーO,O]oxotitanium.A Mild and Efficitent Catalyst for the Michael Reaction of Ketene Silyl Acetals with α,βーUnsaturated Ketones" Chem.Lett.1171-1174 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Efficient Activation of Acetals toward Nucleophiles with[Rh(COD)Cl]_2Catalyst.New Method for the Preparation of Aldols from Acetals and Silyl Enol Ethers by the Combined Use of Catalytic Amounts of[Rh(COD)Cl]_2 and Trimethysilyl Cyanide" Chem.Lett.1273-1276 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "The Addition Reaction of Acetals(Aldehydes)to Simple Olefins by the Use of a New Catalyst System" Chem.Lett.1277-1280 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Kobayashi: "Asymmetric Aldolーtype Reaction between Both Achiral Ketene Silyl Acetals and Aldehydes by the Use of a Chiral Promoter" Chem.Lett.1319-1322 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "A Convenient Synthesis of βーAminoesters.The Reaction of Imines with Ketene Silyl Acetals Catalyzed by Phosphonium Salts" Chem.Lett.1397-1400 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Reductive Cross Cupling Reaction of a Glyoxylate with Carbonyl Compounds.A Facile Synthesis of α,βーDihydroxycarboxylate Based on a Low Valent Titanium Compound" Chem.Lett.1401-1404 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] R.Hara: "[1,2ーBenzenediolato(2ー)ーO,O]oxotitanium.A Chemoselective and Efficient Catalyst for,Aldolーtype Reaction of Ketene Silyl Acetals with Aldehydes" Chem.Lett.1909-1912 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Kobayashi: "A Highly Enantioselective Synthesis of 2ーSubstituted Malates by Asymmetric Aldol Reaction" Chem.Lett.2069-2072 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Catalytic Aymmetric Aldol Reaction of Silyl Enol Ethers with Aldehydes by the Use of Chiral Diamine Coordinated Tin(II)triflate" Chem.Lett.129-132 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Honma: "Stereoselective Addition of tーButyldimethylsiloxyー1ーethoxyethene to 2ーTrichloromethylー1,3ーdioxaneー4ーones" Chem.Lett.161-164 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Kira: "Preparation of Xーray Crystal Structure of the First Pentacoordinate Silysilicates" J.Am.Chem.Soc.111. 3747 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] A.Sekiguchi: "Isolation and characterization of 1,2ーdilithio〔tetrakisー(trimethysilyl)〕ethane" J.Am.Chem.Soc.111. 3748 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Sakamoto: "Novel Anionic Polymerization of Masked Disilenes to Polysilane High Polymers and Block Copolymers" J.Am.Chem.Soc.111. 7641 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Sato,: "Allylation of αーHydroxy Ketones with Allyltrimethylsilanes and Allyltrialkoxysilanes in the Presence of Triethylamire.Stereochemical Regulation Involving Chelated Bicyclic Transition States" J.Am.Chem.Soc.111. 6429 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Kira: "ESR Study of 2ーSubstituted 2ーAdamantyl Radicals.Configuration and Longーrange Hyperfine Interaction" J.Am.Chem.Soc.111. 8256 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Sakurai: "Metamorphosis of Synthetic Strategies with Allylic Sidlanes: Tetracoordinated Allylic Silanes into Pentacoordinated Allylic Silicates" Synlett.1. 1 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Kira: "Highly Stereoselective Allylation of Aldehydes with Pentacoordinate Allylsilicates in Hydroxylic Media. Discrimination between Linear and alphaーbranched Alkanols" J.Am.Chem.Soc.112. 257 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Otsuka: "Manーdesigned Bleomycin with Altered Sequence Specificity in DNA Cleavage" J.Am.Chem.Soc.112. 838-845 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] A.Suga: "TransitionーMetal Binding Site of Bleomycin.A Synthetic AnalogueSuperior to Bleomycin Dioxygen Activating Capability" Synlett.1. 70-71 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Kaku: "Chiral Environment around the Metal Center Obderved by the Epoxidation with the Iron Complex of Bleomycin and the Synthetic Analogue" Chem.Lett.611-614 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Ichikawa: "Selective βーCーand βーSーGlycosylation of 2ーDeoxyribofuranose Derivatives Controlled by the 3ーHydroxy Protecting Group" Bull.Chem.Soc.Jpn.62. 845-852 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Hayashi: "Asymmetric[2+2]Cycloaddition Reaction Catalyzed by a Chiral Titanium Reagent" Chem.Lett.793-796 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Okauchi: "Stereoselective Synthesis of βー2ーDeoxyribonucleosides from 1ー0ーAcetylー3ー0ー[2ー(methylsulfinyl)ethyl]ー2ーdexyribose" Chem.Lett.801-804 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Narasaka: "Kinetic Resolution of αーArylcarboxylic Acid Derivatives by a Catalytic Use of a Chiral Titanium Alkoxide" Chem.Lett.1187-1190 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Narasaka: "Asymmetric DielsーAlder Reaction Catalyzed by a Chiral Titanium Regent" J.Am.Chem.Soc.111. 5340-5345 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] N.Iwasawa: "Characterization of the Chiral Titanium Reagent Prepared from Tartrateーderived Chiral Diol and Titanium Dichloride Diisopropoxide" Chem.Lett.1581-1584 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] N.Iwasawa: "Asymmetric Intramolecular DielsーAlder Reaction Catalyzed bythe Chiral Titanium Reagent" Chem.Lett.1974-1950 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Narasaka: "The Addition Reaction of βーKeto Carboxylic Acids to Olefinic Compounds by the Use of Mn(III)Tris(2ーpyridinecarboxylate)as an Oxidant" Chem.Lett.2169-2172 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Ichikawa: "Enatioー and Diastereoselective Synthesis of Carbocyclic Oxetanocin Analogs" J.Chem.Soc.,Chem.Commun.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Matsuzawa: "ChlorosilaneーAccerelated Conjugate Addition of Catalytic and Stoichiometric Organocopper Reagents" Tetrahedron. 45. 349 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Matsuzawa: "Me_3SiClーAssisted 1,2ーAddition of Organocuprates to Carbonyl Compounds" Tetrahedron Lett.30. 1975 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Horiguchi: "Double Hydroxylation of Enol Sily Ethers.A SingleーStep Synthesis of αーα',ーDihydroxy Ketones" Tetrahedron Lett.30. 3324 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Horiguchi: "Regioselective Synthesis of Two Types of Cyclic 3ー(Trimethylsilylmethyl)ーenones" Tetrahedron Lett.30. 3327 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Horiguchi: "Total Synthesis of(+)ーCortisone.Double Hydroxylation Reaction for Corticoid Synthesis" J.Am.Chem.Soc.111. 6257 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Matsuda: "A Selective OneーCarbon Ring Expansion Reaction of 1ーSilーoxycycloalkanecarbaldehydes Catalyzed by a Lewis Acid" Tetrahedron Lett.30. 4267 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Horiguchi: "A Highly Efficient EightーMembered Ring Cyclization for Construction of Taxane Carbon Framework" J.Am.Chem.Soc.111. 8277 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Aoki: "Palladiumーand PlatinumーCatalyzed Reaction of Siloxycyclopropanes with Acid Chlorides.A Homoenolate Route to 1,4ーDicarbonyl Compounds" Tetrahedron Lett.30. 6541 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Tanino: "SiliconーBased Nucleophiles Mediated OneーCarbon Ring Enlargement Reactions of 1ー(Trimethylsilymethyl)ーcycloalkanecarboaldehydes" Tetrahedron Lett.30. 6551 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Hayashi: "Asymmetric Synthesis Catalyzed by Chiral FerrocenylrhosphineーTransitionーMetal complexes.8.Palladium Catalyzed Asymmetric Allylic Amination" J.Am.Chem.Soc.111. 6301-6311 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Tamao: "Nickel(O)ーCatalyzed Cyclization of 1,7ーDiynes via Hydrosilation:Oneーstep Synthesis of 1,2ーDialkylidenecyclohexanes with a (Z)ーVinylsilane Moiety" J.Am.Chem.Soc.111. 6478-6480 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Ito: "Synthesis of Asymmetric Dialkynyl Imines.Stepwise Coupling of NーPhenyl(phenylthio)imidoyl Chloride with Alkyltin Compounds" Chem.Lett.1261-1264 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Mukaiyama: "Challenges in Synthetic Organic Chemistry(International Series of Monographs on Chemistry No.20)" Oxford University Press, 240 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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