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A trial to Develop a System for Animal Maintenance Free from Trace Element Contamination

Research Project

Project/Area Number 01870029
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKyoto University

Principal Investigator

ITOKAWA Y.  Professor, Dept. of Hygiene, Fac. of Medicine, 医学部, 教授 (80025593)

Co-Investigator(Kenkyū-buntansha) KONDO H.  Instructor. Dept. of Hygiene. Fac. of Medicine, 医学部, 助手 (20205561)
YOKOI K.  Instructor, Dept. of Hygiene, Fac. of Medicine, 医学部, 助手 (10200883)
KIMURA M.  Asso., Prof. Dept. of Hygiene. Fac. of Medicine, 医学部, 助教授 (60025658)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥18,700,000 (Direct Cost: ¥18,700,000)
Fiscal Year 1990: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1989: ¥16,300,000 (Direct Cost: ¥16,300,000)
KeywordsTrace element / Essentiality / Animal maintenance system
Research Abstract

Recently use of total parenteral nutrition and synthetic diets leading to essential trace element deficiencies. Lithium, germanium & rubidium are the possible essential trace element with poor documentation. On the other hand although the essentiality of tin & arsenic has been recognized, their specific physiological effect & deficiency symptom are not clear yet. In conventional animal facilities, contamination of these elements has been unavoidable, and therefore the assessment of such unknown essential trace element is impossible. Although recently in United States and Europe controlled animal facilities avoiding such contamination is available, in Japan there is none. Last year we developed such a system introducing special animal cage and food & water container. This year, using this system, we maintained rats with tin, manganese and rubidium deficient diets. Their blood and other tissues were analyzed for essential trace element, and the data were compared with those obtained from rats maintained in conventional facilities. We confirmed the essentiality of tin, produced manganese deficient rats in shorter period, and shed light on the possibility of essentiality of rubidium.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] A.Matsuda,M.Kimura,M.Kataoka,S.Ohkuma,M.Sato,Y.Itokawa: "Quantifying manganese in lymphocytesto assess mauganese nutritional status" Clin.chem.35. 1939-1941 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Kimura,Y.Itokawa: "Inefficient utilization of irox and minerals in magnesium deficient rats" Magnesium in Health and Disease. 95-102 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Itokawa,S.M.Ahmed,M.Kimura,H.Kondo: "Effects of cellulose on thiamin and magnesium metabolism in magnesium deficient rats" マグネシウム. 9. 101-108 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Miniature bydride generator system for induotiuely coupled plasmaatumic emission spectrometry" Fresenius J Anal Chem. 336. 423-424 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Determination of tin in biological samples using gaseous bydride generationーinductinely coupled plasmaーatomic emission spectrometry." Anal.Biochem. 190. 71-77 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Effet of dietary tin deficiency on growth and mineral status in rals" Biol.Trace Elem Res. 24. 223-231 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura and Y. Itokawa: "Miniature hydride generator system for inductively coupled plasma-atomic emission spectrometry." Fresenius' J. Anal. Chem.336. 423-424 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Yokoi. M. Kimura and Y. Itokawa: "Effect of dietary tin-deficiency on growth and mineral status in rats." Biol. T. Elem. Res.23. 223-231 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura and Y. Itokawa: "Determination of tin in biological samples using gaseous hydride generation-inductively coupled plasma atomic emission spectrometry." Anal. Biochem.191. 71-77 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Itokawa, S. M. Ahmed. M. Kimura and H. Kondo: "Effects of cellulose on thiamin and magnesium metabolism in magnesium deficient rats." JJSMgR. 9. 101-108 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. Matsuda, M. Kimura, K. Yokoi, H. Kabata, M. Kataoka, M. Sato and Y. Itokawa: "Effects of total parenteral nutrition containing essential trace elements on magnesium-calcium ratio in cardiac tissue of rats." Magnesium Research. 2. 21-22 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Mieko Kimura and Yoshinori Itokawa: "Inefficient utilization of iron and minerals in magnesium deficient rats." Magnesium in Health and Disease (Y. Itokawa & J. Durlach, eds) 1989. John Libbey (London). 95-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. Matsuda, M. Kimura, M. Kataoka, S. Ohkuma, M. Sato and Y. Irokawa: "Quantifying manganese in lymphocytes to assess manganese nutritional status." Clin. Chem.35. 1939-1941 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, K. Sekine and Y. Itokawa: "Determination of tin in biological samples by gaseous hydride generation-atomic absorption spectrometry." Trace Nutrients Research. 4. 133-138 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. M. Ahmed, M. Kimura and Y. Itokawa: "Iron and zinc status of protein-energy malnourished rats." Trace Nutrients Research. 4. 121-126 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A.Matsuda,M.Kimura,M.Kataoka,S.Ohkuma,M.Sato,Y.Itokawa: "Quantifying manganese in lymphocytes to assess manganese nutritional status" Clin.Chem.35. 1939-1941 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Kimura,Y.Itokawa: "Inefficient utilization of iron and minerals in magnesium deficient rats" magnesium in Health and Disease. 95-102 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Itokawa,S.M.Ahmcd,M.kimura,H.Kondo: "Effects of cellulose on thiamin and magnesium metabolism in magnesium deficient rats" マグネシウム. 9. 101-108 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura: "Miniature bydride generator system for inductively coupled plasmatomic emission spectrometry" Fresenius J Anal Chem. 336. 423-424 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Determination of tin in biological samples using gaseous bydride generationーinductively coupled plasmaーatomic emission Spectrometry." Anal.Biochem. 190. 71-77 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Effet.of dietary tin deficiency on growth and mineral status in rats" Biol.trace Elem Res. 24. 223-231 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Yokoi: "Effect of dietary tin-deficiency on growth and mineral status in rats" Biol Trace Elem Res. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Yokoi: "Determination of tin in biological samples by gaseous hydride generation-atomic absorption spectrometry." Trace Nutrients Recerch-Recent progress on trace element in nutrition-. 4. 133-138 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Yokoi: "Miniature hydride generator system for inductively coupled palsma-atomic emission spectrometry." Freseninus J Anal Chem. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Kimura: "Iron acumulation and changes of mineral contents in magnesium deficient rats." Magunesium-Bullitein. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] A.Matsuda: "Effects of total parenteral nutrition(TPN)containing essential trace el ements on magnesium-calcium ratio in cardiac tissue of rats." Magnesium Reserch. 2. (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 横井克彦: "鉄欠乏ラットにおける生体内ミネラル類の変動" 微量栄養素研究. 5. 43-50 (1988)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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