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Pathophysiology of Pertpheral Airways in Chronic Obstructive Pulmonary Disease

Research Project

Project/Area Number 01870038
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

SASAKI Hidetada  Professor Tohoku Univ. Sch. of Med., Dept. of Geriatric Medicine, 医学部附属病院, 教授 (20004731)

Co-Investigator(Kenkyū-buntansha) YANAI Masaru  Lecturer Professor, 医学部附属病院, 助手 (00210287)
AIKAWA Takashi  Lecturer Professor, 医学部附属病院, 助手 (60210994)
SHIMIZU Yoshio  Lecturer Professor, 医学部附属病院, 助手 (90005421)
SEKIZAWA Kiyohisa  Lecturer Professor, 医学部附属病院, 助手 (50171335)
志村 早苗  東北大学, 医学部附属病院, 助手 (20154312)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsRespiratory resistance / Anatomic dead space / Peripheral airway / 気道粘液貯留 / 粘膜線毛輸送能 / 順行性カテ-テル / 気道過敏性 / 食道バル-ン法
Research Abstract

Abstract
We studied the effective sites of airway response to atropine and fenoterol aerosols and to the intravenous injection of aminophylline in patients with stable and spontaneous asthma, by the simultaneous assessment of respiratory resistance (Rrs) and anatomic dead space (V_D). Central airway response was determined by V_D, and overall response was determined by Rrs. Peripheral airway response was inferred from Rrs when the change in V_D was slight. Atropine (4 mg/m1) or fenoterol (0.4 mg/ml) was continously inhaled during tidal breathing for 5 min. Inhalation of both atropine and fenoterol increased Grs (reciprocal of Rrs) (p|0.01) with a simultaneous increase in V_D (P|0.01) in the patients with stable and spontaneous asthma. Fenoterol increased Grs more than did atropine at an equivalent increase in V_D in patients with spontaneous asthma (p|0.05). Intravenous injection of aminophylline (250 mg) had no effects on either Grs or V_D in patients with stable asthma, but it significantly increased Grs (P|0.01) without change in V_D in patients with spontaneous asthma. These results suggest that the predominant sites of bronchodilation induced by inhaled atropine are the central airways, and those induced by intravenous injection of aminophylline are the peripheral airways, and that inhaled fenoterol dilates both the central and peripheral airways in asthmatic subjects. Differences among clinically used bronchodilators on the effective sites may be considered in the treatment of bronchial asthma.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Yanai M etal.: "Control of the larynx in patients with obstrutive and restrictive pulmonary impairment" Eur Respin J. 2. 31-35 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Aikawa T etal.: "Morphometric analysis of intaluminal mucus in airways in chronic obstructive pulmonary disease." Am Rev Respir Dis. 140. 477-482 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Miyano Metal.: "Series distribution of muccoiliary clearance of magnetized iron particles in anesthetized dogs" Respir Physiol. 79. 9-18 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yanai M etal.: "Effective site of bronchodilation by antiーasthma drugs in asthmatie subjects" J Allergy Clin Immunol. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Yanai, et al.: "Control of the larynx in patients with obstructive and restrictive pulmonary impairment" Eur Respir J. 2. 31-35 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Aikawa, et al.: "Morphometric analysis of intraluminal mucus in airways in chronic obstructive pulmonary disease" Am Rev Respir Dis. 140. 477-482 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Miyano, et al.: "Series distribution of mucociliary clearance of magnetized iron particles in anesthetized dogs" Respir Physiol. 79. 9-18 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Yanai, et al.: "Effective site of bronchodilation by anti-asthma drugs in asthmatic subjects" J Allergy Clin Immunol. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yanai M.et al.: "Control of the larynx in patients with ofstructive and restrictive pulmonary impairment" Eur Respir J. 2. 31-35 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Aikawa T.et al.: "Morphometric analysis of intraluminal mucus in airways in chronic ofstructive pulmonary disease" Am Rev Respir Dis. 140. 477-482 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Miyano M.et al.: "Series distribution of mucociliary clearance of magnetized iron particles in anesthetized dogs" Respir Physiol. 79. 9-18 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yanai M.et al.: "Effective site of bronchodilation by antiーasthma drugs in asthmatic subjects" J Allergy Clin Immunol. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Sekizawa,M.Yanai,Y.Shimizu,H.Sasaki,T.Takishima: "Series distribution of bronchoconstriction in normal subjects." Am Rev Respin Dis. 137. 1312-1316 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Takishima,M.Yanai,K.Sekizawa,T.Ohrui,H.Sasaki,M.Takahashi,H.Ozawa: "Partitioning of large and small airway resistance in human measured by an anterograde catheter micromanometer" Tohoku J exp Med. 156. 99-100 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Yanai,T.Ohrui,K.Sekizawa,H.Sasaki,T.Takishima: "Laryngeal resistance immediately after panting in asthmatic subjects" Thorax. (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.YANAI,K.Sekizawa,H.Sasaki,T.Takishima: "Control of the larynx in patients with obstructive and restrictive pulmonary impairment" Eur Respir J. 2. 31-35 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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