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Synchronous Pulsatile ECMO System for Neonatal Cardiopulmonary Failure.

Research Project

Project/Area Number 01870055
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

OKADA Akira  Osaka University Medical School, Dept. of Pediatric Surgery, Professor., 医学部, 教授 (40028569)

Co-Investigator(Kenkyū-buntansha) FUKUI Yuichi  Osaka University Medical School, Dept. of Pediatric Surgery, Assistant Professor, 医学部, 助手 (30218896)
KAMATA Shinkichi  Osaka University Medical School, Dept. of Pediatric Surgery, Assistant Professor, 医学部, 助手 (40161202)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1989: ¥7,400,000 (Direct Cost: ¥7,400,000)
KeywordsExtracorporeal Membrane Oxygenation (ECMO) / Pulsatile Flow / Counterpulsation / Endotoxic / Shock / 拡張期カウンタ-パルセイション / 拍動流ECMO / 新生児 / ECMO(呼吸補助) / 拍動流体外循環法
Research Abstract

We designed a synchronous pulsatile V-A ECMO device for neonates to accomplish more effective circulatory support. The effect of this device was studied in an endotoxin-induced shock model, compared with conventional nonpulsatile V-A ECMO.
1. Synchronous pulsatile ECMO system
This system consists of the conventional V-A ECMO circuit a 6.0 ml balloon in the arterial line as a counterpulsator. This balloon is specially designed for neonates and is driven with an electrocardiogram triggering mechanism. In a preliminary experimental study using puppies, blood pressure, renal blood flow and urinary output were significantly higher during pulsatile ECMO than nonpulsatile ECMO.
2. Effects of pulsatile ECMO in an endotoxin shock model
Twenty puppies weighing 1.6 to 4.0 kg were given endotoxin (5mg/kg) intravenously. Thirty minutes after the administration of endotoxin, ten of those were placed on pulsatile ECMO, and the others were placed on nonpulsatile ECMO. All of the animals were studied for additional 180 minutes. Low blood pressure, reduced renal blood flow and progressive metabolic acidosis were demonstrated in nonpulsatile ECMO. On the other hand, blood pressure and renal blood flow were well maintained, and metabolic acidosis was improved in pulsatile ECMO. There were no significant difference in the serum free hemoglobin levels between pulsatile and nonpulsatile ECMO.
3. Conclusion
These results indicate that pulsatile ECMO may provide effective cardiopulmonary support in the treatment of neonates with serious circulatory failure which has been failed to support by nonpulsatile ECMO.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 奥山 宏臣他: "新生児用拍動流ECMO装置の試作及びその有用性に関する研究" 人工臓器. 20. 1134-1137 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroomi Okuyama et.al: "Effects of Synchronous Pulsatile ECMO in An Endotoxin-Induced Shock Model:An Experimental Study" Artificial Organs.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Okuyama H, et al: "SYNCHRONOUS PULSATILE ECMO SYSTEM FOR NEONATAL CARDIOPULMONARY FAILURE: AN EXPERIMENTAL STUDY" Jpn J Artif Organs. 20(3). 1134-1137 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Okuyama H, et al: "Effects of Synchronous Pulsatile ECMO in An Endotoxin-Induced Shock Model" Artificial Organs.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 奥山 宏臣他: "新生児用拍動流ECMO装置の試作及びその有用性に関する研究" 人工臓器. 20. 1134-1137 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hiroomi Okuyama et.al.: "Effects of Sychronous Pulsatile ECMO in An Endotoxin-induced Shock Model:An Experimental Study" Artificial Organs.

    • Related Report
      1991 Annual Research Report
  • [Publications] 奥山 宏臣 鎌田 振吉 岡田 正: "新生児用拍動流ECMO装置の試作及びその有用性に関する検討" 人工臓器. 20. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 奥山 宏臣 鎌田 振吉 岡田 正: "胎児水腫に対するECMOの施行経験" 日本新生児学会雑誌. 27. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 奥山 宏臣,鎌田 振吉 岡田 正: "新生児ECMOの循環補助効果に関する検討" 日本外科学会雑誌(抄録集). 91. 220 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 奥山 宏臣,鎌田 振吉 岡田 正: "新生児用拍動流ECMO装置の試作及びその有用性に関する基礎的検討" 日本小児外科学会雑誌. 26. 441 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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