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Development of a pulsatile perfusion apparatus for heart preservation with myocardial impedance monitor

Research Project

Project/Area Number 01870059
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

KANEKO Mitsunori (1990-1991)  Osaka Univ Med School, assist prof, 医学部, 助手 (70169580)

川島 康生 (1989)  大阪大学, 医学部, 教授 (10028425)

Co-Investigator(Kenkyū-buntansha) FUKUSHIMA Noriatsu  Osaka Univ Med School, Senior Resid, 医学部附属病院, 医員
MIYAMOTO Yuji  Osaka Univ Med School, assist Prof, 医学部, 助手 (80229898)
KADOBA Keishi  Osaka Univ Med School, assist Prof, 医学部, 助手 (00185886)
NAKATA Seizoh  Osaka Univ Med School, assist Prof, 医学部, 助手 (50116068)
SHIRAKURA Ryota  Osaka Univ Med School, assoc Prof, 医学部, 助教授 (00116047)
福島 教偉  大阪大学, 医学部附属病院, 医員
川口 章  大阪大学, 医学部, 助手 (30195052)
金香 充範  大阪大学, 医学部, 助手 (70169580)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 1990: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1989: ¥9,000,000 (Direct Cost: ¥9,000,000)
Keywordsheart preservation / pulsatile flow / heart transplantation / impedance / 心臓移植 / 潅流保存 / 低温保存
Research Abstract

This study was done to develop a portable perfusion apparatus for heart preservation in which hearts are hypothermically perfused with pulsatile pump for 24 hours and myocardial impedance is continuously measured to assess the myocardial edema. At first we evaluated simple immersion methods for preservation as control with Langendorf using isolated rabbit heart. The left ventricular function after 24 preservation in UW solution was better than in saline and modification at reperfusion, leukocyte depleted terminal cardioplegia, enhanced LV function to sustain the normal circulation after orthotopic heart transplantation in dog. The portable perfusion apparatus with a diaphragm driven by electromagnetic power which derivesd pulsatile flow was made. In vitro test with the apparatus showed 0.05-5ml of stroke volume, 60-120 beat/min, and 15-150 mmHg of perfusion pressure which could be controllable for isolated rabbit heart perfusion. The temperature, however, was difficult to maintain to 10 C during 24 hours perfusion because of the effect of room temperature especially when a "portable" apparatus was desired. Moreover conventional impedance meter should be used at constant temperature and it was proved that the value of tissue impedance at variable temperature was unreliable and worthless.

Report

(3 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Fukushima N,Nakano S,Shirakura R.: "Effects of terminal cordioplegia with leukocyte-depleted blood on myocardial ATP of heart preserved 24 hours." Transplantation Proceedings.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakura R,Matsuda H,Nakano S,Kaneko M,Kawaguchi A,Miyamoto Y,Matsuwaka R,Kitagawa S,Fukushima N,Kawashima Y.: "24-hours storage for asphyxiated canine hearts with use of Belzer University of Wisconsin solution." Transplantation Proceedings. 23. 662-663 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakura R,Matsuda H,Nakano S.: "A new method to harvest multiple organs from on-heart-beating donor byuse of percutaneous cardiopulmonary supporting machiene." Transplantation Proceedings.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakura R,Matsuda H,Nakano S,Nakata S,Kaneko M,Miyamoto Y,Matsuwaka R,Kitagawa S,Fukushima N,Kawashima Y.: "Cavdiac function and myocardial performance of 24hour preserved asphyxiated canine heart." Ann Thorac Surg. 53. 440-444 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fukushima N,Nakano S,Shirakura R,Matsuda H.: "Effects of terminal cardioplegia with leuko-cyte depleted blood on heart graft preserved 24hours"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fukushima N, Nakano S, Shirakura R.: "Effects of terminal cardioplegia with leukocyte-depleted blood on myocardial ATP of heart preserved 24 hours." Transplantation Proceedings.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakura R, Matsuda H, Nakano S, Nakata S, Kaneko M, Kawaguchi A, Miyamoto Y, Matsuwaka R, Kitagawa S, Fukushima N, Kawashima Y.: "24-hours storage for asphyxiated canine hearts with use of Belzer University of Wisconsin solution." Transplantation Proceedings.23. 662-3 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakura R, Matsuda H, Nakano S.: "A new method to harvest multiple organs from non-heart-beating donor by use of percutaneous cardiopulmonary supporting machine." Transplantation Proceedings.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakura R, Matsuda H, Nakano S, Nakata S, Kaneko M, Miyamoto Y, Matsuwaka R, Kitagawa S, Hukushima N, Kawashima Y.: "cardiac function and myocardial performance of 24 hour preserved asphyxiated canine heart." Ann Thorac Surg.53. 440-4 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fukushima N, Nakano S, Shirakura R.: "Effects of terminal cardioplegia with leukocyte-depleted blood on heart graft preserved 24 hours."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N.Fukushima,M.Kaneko: "Safe method of hypothermic heart preservation for 24hours with terminal worm blood Cardioplegia using leukocyteーdopleted blood for heart Transplantation" J.Heart transplantation.

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2019-02-15  

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