| Project/Area Number |
01870117
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Department of Legal Medicine and Human Genetics Jichi Medical School |
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Principal Investigator |
IKEMOTO Shigenori Jichi Medical School M. D., Ph. D. Professor, 医学部, 教授 (90048942)
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| Co-Investigator(Kenkyū-buntansha) |
HUKUI emiko Jichi Medical School M. S. Assistant, 医学部, 助手 (20208341)
TSUCHIDA Shuichi Jichi Medical School M. D., Ph. D. Assistant, 医学部, 助手 (20217326)
IWAMOTO Sadahiko Jichi medical School M. D., Ph. D. Assistant, 医学部, 助手 (10232711)
KAJII Eiji Jichi Medical School M. D., Ph. D. Lecturer, 医学部, 講師 (40204391)
富田 功一 自治医科大学, 医学部, 教授 (10048936)
三浦 恭定 自治医科大学, 医学部, 教授 (60048965)
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1989: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | BMT / Gene markers / Transformation / DNA polymrphism / GVHD / Red Cell markers / Forensic Science / Human genetics / RFLP / 組織適合性試験 / DPβ・DQβ・DRβプロ-ブ / 制限酵素 / 標識遺伝子の挙動 / 血液型の転換 / 血球酵素型の転換 / 血清蛋白型の変化 / 骨髄移植後の個人識別 / 骨髄移植の生着効果 / 標識遺伝子産生のネットワ-ク / 唾液型と骨髄移植 / 骨髄移植と血清型 / 個人識別と骨髄移植 / 骨髄の標識遺伝子産生 |
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| Research Abstract |
The outhers report studies on 16 pairs of donors and recipients in bone marrow transplantation(BMT). A broad range of gene markers at approximately 40 gene loci, and DNA polymorphisms(RFLPs and VNTR)were evaluated before and after BMT over 1 and 17 months. As a experimental results, 20 loci genetic markers in recipients were transformed into the donor types. BMT between family members may lead to transformation of gene markers, but within a oattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in legal medicin using genetic markers as an index, the appearance of a phenotype incompatoble with a blood relationship is possible after BMT with a non-blood relative donor. In this result is similar to inheritance pattern observed after artificial insemination by a donor's somen, a more complete out-of family corss. In conclusion, bone marrow transplantation is a treatment modality to which human, geneticists have contributed signifcantly by providing multiple valuable techniques for identification. of the source of. marrow in the transplant patient.
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