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Primary Study of the Universal Influenza Vaccine that Images Viral Receptor

Research Project

Project/Area Number 01880021
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field 物質生物化学
Research InstitutionUniversity of Shizuoka, School of Pharmaceutical Science

Principal Investigator

SUZUKI Yasuo  Department of Biochemistry, University of Shizuoka School of Pharmaceutical Science, Professor, 薬学部, 教授 (00046278)

Co-Investigator(Kenkyū-buntansha) 岡 徹也  化学及血清療法研究所, 開発室, 室長
NEROME Kuniaki  National Institute of Health (Tokyo), Chief of the Department, Tesuya Oka, Insti, ウイルスリケッチア, 室長 (00072934)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsInfluenza Virus / Receptor / Hemagglutinin / Neuraminidase / Ganglioside / Monoclonal Antibody / Vaccine / Antiidiotype antiody / インフルエンザワクチン / ノイラミニダ-ゼ / モノクロ-ナル抗体 / 抗イディオタイプ抗体
Research Abstract

This project is aimed to study primarily the developing the universal influenza vaccine, which is widely effective, independent of the variation of the viral hemagglutinin gene in relation to the anti-idiotypic antibody against the antibody directed to the influenza virus receptor.
During the course of this study, following new results were obtained.
1) A new simple and improved assay method to determine the receptor specificity of influenza virus variant has been developed. This method is based on the binding of the virus to the sialoglycosphingolipids (gangliosides) or sialogly-coprotein developed in silica gel thin layer plate or film blotted from the gel after electrophoresis.
2) The simple method for the fractionation and isolation of receptor gangliosides for influenza viruses was developed. This method is based on the mapping the ganglioside species by chromatography using a new anion exchange beads (Q-sepharose).
3) ALL the base sequences of the gene and the receptor specificity of … More viral hemagglutinin subtype (H1 - H13) were determined. It was found that NeuAcalpha2, 3 (6) Galbeta1, 3 (6) GlcNAcbeta1- is the most active receptor determinant which is commonly recognized by all the hemagglutin subtypes. The recogn ition of the hemadgglutinin the linkage between NeuAc and Gal (alpha2, 3 and alpha2, 6) was not always depend on the amino acid 226 (Leu or Gln) in the receptor binding pocket in the hemagglutinin molecule.
4) Single amino acid substitution of Ser (205) located distant from the receptor binding pocket, antigenic site D of A/Mem/1/71-Bel/42 (H3N1), to Tyr changed the receptor binding specificity from 2, 3 to 2, 6. Ser (205) is located across the subunit interface from the receptor-binding site. The bultky hydrophobic tyr in the variant may cause a conformational change in the receptor-binding pocket on the neighboring subunit and influence the receptor binding.
5) A new monoclonal antibody (NS24) directed to sialylparagloboside (NeuAcalpha2, 3Galbeta1, 4GlcNAcbeta1, 3Galbeta1, 4Glcbeta1-Ceramide), a common receptor gangioside of influenza A viruses was prepared. This antibody was highly specific toNeuAc2, 3Gal1, 4GlcNAc1- residue of sialylparagloboside and inhibit the binding of the A virus to erythrocytes which had been treated with sialidase and then reconstituted with sialylparagloboside. This antibody may be useful as an universal influenza vaccine effective to the wide variety of subtypes of influenza virus hemagglutinin.
6) The strategy for the developing the universal influenza virus vaccine was discussed in relation to the anti-idiotypic antibody against the antibody directed to the influenza virus receptor, sialylparagloboside.
7) A new common competitive inhibitor of influenza virus neuraminidase, ganglioside which contained thio-glycoside linkage between NeuAc and Gal was found. Less

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (79 results)

All Other

All Publications (79 results)

  • [Publications] Yasuo Suzuki,K.Sato,M.Kiso,A.Hasegawa: "New Ganglioside Analogs that inhibit influenza virus sialidase" Glycoconjugate J.,. 7. 349-356 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Hirabayashi,A.Hyogo,T.Nakao,K.Tsuchiya,Yasuo Suzuki,M.Matsumoto: "Isolation and characterization of extremely minor gangliosides,GMlb and GDl in adult bovine brain as developmentally regulated antigens" J.Biol.Chem.278. 8144-8151 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki,K.Sato,M.Kiso,A.Hasegawa: "New Ganglioside analogs that inhibite influenza virus sialidase" IXth International Catbohydrate Symposium(August 12ー17,1990,Yokohama,Japan),Abstract Book pp.240(1990). 240 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki: "Recognition of receptor sialylglycoconjugates by influenza virus hemagglutinin" IXth International Carbohydrate Symposium(August 12ー17,1990,Yokohama,Japan),Abstract Book pp.130(1990). 130 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N.Morita,H.Ogawa,Y.Kojima,M.Kiso,A.Hasegawa: "Synthesis of Thioglycosideーanalogs of gangliosides" IXth International Carbihydrate Symposium(August 12ー17,1990,Yokohama,Japan),Abstract Book,pp.222(1990). 222 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki: "Glycolipid recognition of influenza virus hemagglutinin and neuraminidase" J.Glycosphingolipid Research. 1. 25-27 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki: "Biological Role of O__ーーacetylate sialic acid" Trends in Glycosci.and Glycotech.3. 112-118 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N.Iwamoto,Yasuo Suzuki,Y.Makino,C.Haga,K.Kosaka,R.Iizuka: "Cell membrane changes in brains manifesting plaques: an immunohistochemical study og GMl membrane ganglioside" Brain Research. 522. 152-156 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫: "インフルエンザウイルスヘマグルチニンおよびノイラミュタンゼの細胞膜シアル酸含有糖鎖認識の機構" 生化学. 62. 231-260 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫.伊藤 毅.加藤 秀成,信沢 枝里 他: "インフルエンザウイルスヘマグルチニン全亜型(H1〜H13)遺伝子塩基配列の決定、変異およびガングリオシドに対する認識特異性の変化ー" 脂質生化学研究. 32. 79-84 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫: "インフルエンザウイルスレセプタ-" 免疫薬理. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫: "微生物の付着.侵入.増殖 インフルエンザウイルス" 臨床と微生物. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 伊藤 毅 他: "インフルエンザウイルス結合性ガングリオシドの簡便から高感度なアッセイ法の開発" 第38回日本ウィルス学会総会講演要旨集. 177- (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫 他: "硫酸化ガングリオシドの抗ヒト免疫不全症ウィルス(HIU)作用" 日本薬学会第110年会講演要旨集. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 小則 憲司,小林 一成,竹原 洋一,鈴木 康夫,他: "アルツハイマ-型痴呆脳におけるガングリオシドの変化" Dementia. 5. 85-90 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki,H.Nishi,K.Hidari,Y.Hirabayashi,M.Matsumoto,K.Kobayasi: "A new monoclonal antibody directed to sialyl 2ー31actoneotetrasylceramide and its application for human gastrointestinal neoplasmas" J.Biochem.109. 354-360 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] E.Nobusawa,T.Aoyama,H.Kato,Yasuo Suzuki,Y.Tateno,K.Nakajima: "Structure of complete amino acid sequences and receptor properties among thirteen serotypes of hemagglutinin of influenza viruses" Virology. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A.Handa,H.Hoshino,K.Nakajima,Y.Suzuki et al.: "Inhibition of infection with human immunodeficiency virus type 1 by sulfated gangliosides" Biochem.Biophys.Res.Commun.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫: "薬学研究の進歩(インフルエンザウイルスヘマグルチニン遺伝子の変異、糖鎖認識機構ー新広域インフルエンザワクチン開発)" 日本薬学会, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫: "ガングリオシドの生物学的機能発現機構(文部省科学研究費一般B報告書)" (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 鈴木 康夫(共著): "日本生化学会編 新生化学実験講座 III糖脂質.ウイルス" 東京化学同人, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki, Kazuya Hidari, Makoto Matsumoto, Masa-aki Ikeda and Nobuo Tsuchida: "Altered ganglioside expression in ras-oncogene transformed cells" J. Biochem.106. 34-37 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshio Hirabayashi, Mitsue Hirota, Yasuo Suzuki, Makoto Matsumoto, Kunihiko Obata and Suszumu Ando: "Developmentally expressed ganglioside alkali-labile GT3 in fetal rat cerebral cortex" Neuroscience Lett.106. 193-198 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki, Hideshige Kato, Clayton W. Naeve, and Robert G. Webster: "Single amino acid substitutions in an antigenic site of infleunza virus hemagglutinin can alter receptor binding specificity for gangliosides" J. Virology. 62(10). 4298-4302 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshio Hirabayashi, Atsushi Hyogo, Toru Nakao, Koji Tsuchiya, Yasuo Suzuki, Makoto Matsumoto, Kazuo Kon, and Susumu Ando: "Isolation and characterization of extremely minor gangliosides, GM 1 b and GD1alpha in adult bovine brains as developmentally regulated antigens" J. Biol. Chem.8144-8151 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N. Morita, H. Ogawa, Y. Kojima, H. Ishida, M. Kiso, A. Hasegawa, and Y. Suzuki: "Synthesis of Thioglycoside-analogs of Gangliosides" XVth International Carbohydrate Symposium (August 12-17, Yokohama, Japan), Abstract Book. 130 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki, Katsuhiko Sato, Makoto Kiso and Akira Hasegawa: "New ganglioside analogues which inhibit influenza virus sialidase" XVth International Carbohydrate Symposium (August 12-17, 1990, Yokohama, Japan), Abstract Book. 240 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Suzuki, Y.: "Recognition of Receptor Sialylglycoconjugates by Influenza Virus Hemagglutinin" XVth International Carbohydrate Symposium (August 12-17, Yokohama, Japan), Abstract Book. 222 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Norihiko Iwamoto, Yasuo Suzuki, Yutaka Makino, Chie Haga, Kenji Kosaka and Reiji Iizuka: "Cell membrane changes in brains manifesting plaques : an immuno-histochemical study of GM1 membranous ganglioside" Brain Res.522. 152-156 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki: "Biological role of omicron-acetylated sialic acid" Trends in Glycosci. and Glycotech.3. 112-118 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki: "Glycolipid recohmition of influenza virus hemagglutinin and neuraminidase" J. Glycosphingolipid Res.1. 25-27 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki, Katsuhiko Sato, Makoto Kiso and Akira Hasegawa: "New ganglioside analogs that inhibit influenza virus sialidase" Glycoconjugate J.7. 349-356 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki, Hiroshi Nishi, Kazuya Hidari, Yoshio Hirabayashi, Makoto Matsumoto, Shinobu Watarai, Tatsuji Yasuda, Jun Nakayama, Hiroshi Maeda, Tsutomu Katsuyama, Masamitsu Kanai, Makoto Kiso and Akira Hasegawa: "A new monoclonal antibody directed to sialy1alpha2-3lactoneotetraosylceramide and its application for human gastrointestinal neoplasmas" J. Biochem.109. 354-360 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] E. Nobusawa, T. Aoyama, K. H. Kato, Yasuo Suzuki, Y. Tateno, K. Nakajima: "Structure of complete amino acid sequences and receptor binding properties among thirteen serotypes of hemagglutinins of influenza viruses" Virology. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Atsushi Handa, Hiroo Hoshino, Katsuyuki Nakajima, Masakazu Adachi, Kiyoshi Ikeda, Kazuo Achiwa, Takeshi Ito, and Yasuo Suzuki: "Inhibition of infection with human immunodeficiency virus type I by sulfated gangliosides" Biochem. Biophys. Res. Commun.175. 1-9 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Koji Tsuchiya, Kiyoko Mabuchi, Yasuo Suzuki, Yoshio Hirabayashi: "Sialylation of disialoganglioside GD3 by sialyltransferase from embryonic chicken brain : Key enzyme of "c"-series ganglioside expression" Biochim. Biophys. Acta. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Koji Tsuchiya, Yasuo Suzuki, Yoshio Hirabayashi, Hisako Sakiyama: "Characterization of sialyltransferase of B-16 melanoma cells involved in the formation of melanoma associated antigen GM3" Japan J. Cancer Res.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yasuo Suzuki,K.Sato,M.Kiso,A.Hasegawa: "New Ganglioside Analogy that inhibit influenza virus sialidase" Glycoconjugate J.,. 7. 349-356 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Hirabayashi,A.Hyogo,T.Nakao,K.Tsuchiya,Yasuo.Suzuki,M.Matsumoto: "Isolation and characterization of extremely minor gangliosides,GMIb and GDl in adult bovine brain as developmentally regulated antigens" J.Biol.Chem.278. 8144-8151 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yasuo Suzuki,K.Sato,M.Kiso,A.Hasegawa: "New Ganglioside analogs that inhibite influenza virus sialidase" IXth International Carbohydrate symposium (August 12ー17,1990,Yokohama,Japan),Abstract Book pp.240(1990). 240 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yasuo Suzuki: "Recognition of receptor sialylglycocojugates by influenza virus hemagglutinin" IXth International Carbohydrate syposium (August 12ー17,1990,Yokohama,Japan),Abstract Book pp.130(1990). 130 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.Morita,H.Ogawa,Y.Kojima,M.Kiso,A.Hasegawa: "Synthesis of Thioglycosideーanalogs of gangliosides" IXth International Carbihydrate symposium (August 12ー17,1990,Yokohama,Japan),Abstract Book pp.222(1990). 222 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yasuo Suzuki: "Glycolipid recognition of influenza virus hemagglutinin and neuraminidase" J.Glycosphingolipid Research. 1. 25-27 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yasuo Suzuki: "Biological Role of O__ーーacetylate sialic acid" Trends in glycosci.and Glycotech.3. 112-118 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.Iwamoto,Yasuo Suzuki,Y.Makino,C.Haga,K.Kosaka,R.Iizuka: "Cell membrane changes in brains manifesting plaques:an immunohistochemical study og GMl membrane ganglioside" Brain Research. 522. 152-156 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫: "インフルエンザウイルスヘマグルチニンおよびノイラミンタンゼの細胞膜シアル酸含有糖鎖認識の機構" 生化学. 62. 231-260 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫,伊藤 毅,加藤 秀成,信沢 枝里他: "インフルエンザウイルスヘマグルチニン全亜型(H1〜H13)顧伝子塩基配列の決定、変異およびガングリオシドに対する認識特異性の変化ー" 脂質生化学研究. 32. 79-84 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫: "インフルエンザウイルスレセプタ-" 免疫薬理. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫: "微生物の付着、侵入、増殖インフルエンザウイルス" 臨床と微生物. (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 伊藤 毅他: "インフルエンザウイルス結合性ガングリオシドの簡便から高感度なアッセイ法の開発" 第38回日本ウイルス学会総会講演要旨集. 177 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫他: "硫酸化ガングリオシドの抗ヒト免他不全症ウイルス(HIV)作用" 日本薬学会第110年会講演要旨集. (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小阪 憲司,小林 一成,竹原 洋一,鈴木 康夫他: "アルツハイマ-型痴呆脳におけるガングリオシドの変化" dementia. 5. 85-90 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yasuo Suzuki,H.Nishi,K.Hidari,Y.Hirabayashi,M.Matsumoto,K.KobayasI: "A new monclonal antibody directed to sialyl 2ー3lactoneotetraosylceramide and its application for human gastrointestinal neoplasmas" J.Biochem.109. 354-360 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] E.Nobusawa,T.Aoyama,H.Kato,Ysauo Suzuki,Y.Tateno,K.Nakajima: "Structure of complete amino and sequences and receptor properties among thirteen serotypes of hemagglutinin of influenza viruses" Virology in press. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] A.Handa,H.Hoshino,K.Nakajima,Y.Suzuki et al.: "Inhibition of infection with human immunodeficiency virus type 1 by sulfated gangliosides" Biochem.Biophys.Rec.Commun.in press. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫: "薬学研究の進歩(インフルエンザウイルスヘマグルチニン遺伝子の変異、糖鎖認識機構ー新広域インフルエンザワクチン開発)" 日本薬学会, (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫: "ガングリオシドの生物学的機能発現機構(文部省科学研究員一般B報告書)" (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 康夫(共著): "日本生化学会編 新生化学実験講座III.糖脂質.ウイルス" 東京化学同人, (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Suzuki,Y.,Hidari,K.,Matsumoto,M.,Ikeda,M.and Tsuchida,N.: "Altered Ganalioside expression in ras-oncogene transformed cells" J.Biochem.106,34ー37. 106. 24-37 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hirabayashi,Y.,Hirota,M.,Suzuki,Y.,Matsumoto,M.,Obata,K.et al: "Developmentally expressed ganglioside alkali-labile GT3 in fetal rat cerebral cortex" Neuroscience Lett.,. 106. 193-198 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,Y.,Kato,H.,Naeve,C.,and Webster,G.: "Single amino acid substitution in an antigenic site of influenza virus hemagglutinin can alter receptor binding specificity for gangliosides" J.Virology. 62. 4298-4302 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hirabayashi,Y.,Hyogo,A.,Nakao,T.,Tsuchiya,K.,Suzuki,Y.et al: "Isolation and characterization of extremely minor gangliosides,GM1b and GD1alpha in adult bovine brains as developmentally regulated antigens" J.Biol.Chem.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,Y.,Sato,K.,Kiso,M.and Hasegawa,A.: "New ganglioside analogues which inhibit influenza virus sialidase" XVth International Carbohydrate Symposium(August 12ー17,1990). (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,Y.: "Recognition of Receptor Sialylglycoconjugates by Influenza virus hemagglutinin" XVth International Carbohydrate Symposium(August 12ー17,1990). (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Morita,N.,Ogawa,H.,Kojima,Y.,Ishida,H.,Suzuki,Y.et al: "Synthesis of thioglycoside-analogs of gangliosides" XVth International Carbohydrate Symposium(August,12ー17,1990). (1990)

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      1989 Annual Research Report
  • [Publications] Suzuki,Y.,Nishi,H.et al.: "A new monoclonal antibody directed to sialy 1 alpha 2-3 lactoneotetraosylceramide and its application for human gastrointestinal neoplasmas" Eur.J.Biochem.(1990)

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      1989 Annual Research Report
  • [Publications] Matsumoto,Y.,Suzuki,Y.,Kanjaki,T.,Hirabayashi,Y.: "Sensitive HPLC analysis of endo-and exoglycosidases acting on new substrate of O__ー-linked glycans" Analytical Biochem.submitted.

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "癌関連抗原としての糖脂質" 細胞(特集:情報伝達因子モジュレ-タ-としての脂質). 21. 182-186 (1989)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫,平林義雄: "細胞膜表面ガングリオシドの生物学的機能発現調節機構" 内藤財団時報. 43. (1990)

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      1989 Annual Research Report
  • [Publications] 平林義雄,兵庫淳志,中尾徹,鈴木康夫,松本亮 等: "牛脳中の極微量ガングリオシドGM_<1b>,GD_<1alpha>の存在とその意義" 脂質生化学研究. 30. 41-44 (1989)

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      1989 Annual Research Report
  • [Publications] 平林義雄,松本幸恵,神崎保,鈴木康夫: "Augiokeratomaを伴う新しい糖代謝異常症の生化学的研究" 第12回糖質シンポジウム講演要旨. (1989)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "糖タンパク質糖鎖はどのようにつくられるのかー胃粘膜および細胞膜糖タンパク質の生合成" Cliniciann. 36. 897-901 (1989)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "インフルエンザウイルスヘマグルチニン遺伝子の変異と糖鎖レセプタ-認識の機構ー新しい広域インフルエンザワクチン開発への応用ー" 薬学研究. (1990)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "インフルエンザウイルスヘマグルチニンおよびノイラミンタンゼの細胞膜シアル酸含有糖鎖認識の機構" 生化学. 62. (1990)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "糖タンパク質糖鎖の生合成および細胞内輸送" Medical Tribune. (1990)

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      1989 Annual Research Report
  • [Publications] Suzuki,Y.: "Biological Roles of O-acetylated sialic acid" Trends in Glycoscience and Glycotechnology. 2. (1990)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "O__ーーアセチル化シアル酸の生物学的意義" Trends in Glycoscience and Glycotechnology. 2. (1990)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫: "新生化学実験講座(第4巻)脂質III糖脂質" 東京化学同人(日本生化学会編), (1990)

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      1989 Annual Research Report
  • [Publications] 鈴木康夫,松本亮: "文部省科学研究費補助金(総合A)新視点より行なう 細胞機能発現とリン脂質の役割の研究" (1989)

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      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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