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Integrative studies on acclimatization mechanism to extreme altitude hypoxia in Himalayan areas - A joint project of Kyoto and Chida University

Research Project

Project/Area Number 02041047
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research InstitutionKyoto University

Principal Investigator

HORI Ryohei (1991-1992)  Professor, Faculty of Medicine, Kyoto University, 医学部, 教授 (40001036)

戸部 隆吉 (1990)  京都大学, 医学部, 教授 (70025641)

Co-Investigator(Kenkyū-buntansha) FURUKAWA Akira  Associate Professor, Faculty of Sociology, Chukyo University, 社会学部, 助教授
IMAI Ichiro  Associate Professor, Faculty of Humanities, Hirosaki University, 人文学部, 助教授 (50160023)
TAKAI Masanaru  Special Researcher, Primate Research Institute, Kyoto University, 霊長研, 特別研究員
YONEMOTO Shohei  Director, Mistubishi Kasei Life Science Institute, 室長
KAWAI Akinobu  Lecturer, Faculty of Agriculture, Kyoto University, 農学部, 講師 (90195024)
HIKAMI Koji  Special Researcher, Primate Research Institute, Kyoto University, 霊長研, 特別研究員
KAN Norimichi  Assistant Professor, Faculty of Medicine, Kyoto University, 医学部, 助手 (50186160)
MASUDA Atsuko  Lecturer, College of Medical Technology, Shinshu University, 医短, 講師 (70165710)
SAKAKIBARA Yoshikazu  Lecturer, Faculty of Medicine, Chiba University, 医学部, 講師 (50092060)
スン 乗庸  中国第三軍医大学, 教授
ENDO Katsuaki  Assistant Professor, Faculty of Medicine, Kyoto University, 医学部, 助手 (30025613)
KIMURA Hiroshi  Assistant Professor, Faculty of Medicine, Chiba University, 医学部, 助手 (20195374)
SETO Shiro  Lecturer, Shimane Medical School, 医学部, 講師 (00196974)
MATSUBAYASHI Kozo  Lecturer, Kochi Medical School, 医学部, 講師 (70190494)
MASUYAMA Shigeru  Assistant Professor, Faculty of Medicine, Chiba University, 医学部, 助手 (00219354)
MATSUZAWA Tetsuro  Associate Professor, Primate Research Institute, Kyoto University, 霊長研, 助教授 (60111986)
FUKUDA Koichiro  Associate Professor, Faculty of Medicine, Chiba University, 医学部, 助教授 (10009649)
TOBE Takayoshi  Professor, Faculty of Medicine, Chida University, 医学部, 教授 (70025641)
KURIYAMA Takayuki  Professor, Faculty of Medicine, Chida University, 医学部, 教授 (20009723)
HONDA Yoshiyuki  Professor, Faculty of Medicine, Chida University, 医学部, 教授 (30019525)
T.M. アマッチャ  トリブバン大学, 医学部, 助教授
TARA Man Amatya  Associate Professor, Inst. of Medicine & Teaching Hospital, Tribhuvan University
CHENG Yong Shun  Professor, The Third Military Medical School of China
すん 乗庸  中国第三軍医大学, 教授
アマッチャ T.M.  トリブバン大学, 医学部, 助教授
松林 清明  京都大学, 霊長類研究所, 助教授 (50027497)
楊 雄里  上海生理研究所, 所長
平田 和男  京都大学, 医学部, 助手 (00201731)
土 登  チベット自治区, 衛生庁, 副庁長
孫 新甫  チベット医学科学研究所, 所長
木田 光郎  名古屋大学, 環境医学研究所, 助教授 (80023654)
堀 了平  京都大学, 医学部, 教授 (40001036)
Project Period (FY) 1992 – 1993
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥32,000,000 (Direct Cost: ¥32,000,000)
Fiscal Year 1992: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1991: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1990: ¥12,000,000 (Direct Cost: ¥12,000,000)
KeywordsHunza / Vilcabamba / aging / development / neurobehavioral functions / 高所住民 / 健康度 / 近代文明 / 血圧 / 低酸素環境 / ライフスタイル / 低酸素適応 / 低酸素症 / 疫学調査 / ニホンザル / エリスロポエチン / 眼底像 / 超音波画像診断
Research Abstract

Geriatric functional assessment and socio-cultural survey in Hunza in Pakistan were investigated. The scores in neurobehavioral functions in the older elderly (over 75 year-old)in Hunza were higher than the older elderly in Japan. Al though the female elderly were healthier than the male one in Japan, the male elderly were healthier than the female one in Hunza. The scores in subjective happiness evaluated by visual analogue scale was significantly lower in the female elderly in Hunza than in the male elderly in Hunza or Japan elderly population. The correlation between age and systolic blood pressure was different among the villages in Hunza area.
Geriatric functional assessment and socio-cultural survey was investigated also in Vilcabamba in Equador which was known to be the area of long-living people, as well as Hunza. The scores in each index of neurobehavioral functions were significantly correlated with age in Vilcabamba as well as in Hunza and in Japan, indicating that each indices we adopted was suitable to the method to assess the geriatric functions. The scores in neurobehavioral functions in the older elderly in Vilcabamba were not higher than those in Japan. The scores in subjective healthiness, economical condition and happiness were lower in the elderly in Vilcabamba than in ones in Japan.
As well as geriatric functional assessment, development milestone and risk factors for cardiovascular diseases in children in Andean area were also investigated.
Both biological aging and development were suggested to be influenced by not only genetic factors but also socio-cultural life style.

Report

(3 results)
  • 1992 Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (56 results)

All Other

All Publications (56 results)

  • [Publications] MATSUBAYASHI,K.: "Incidental brain lesion on magnetic resonance imahing and neurobehavioral functions in the apparently healthy elderly." Stroke. 23. 175-180 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松林 公蔵: "″Visual Analogue Scale″による老年者の「主観的幸福度」の客観学標価I -標準的うつ尺度との関連-" 日本老年医学会雑誌. 29. 811-816 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松林 公蔵: "″Visual Analogue Scale″による老年者の「主観的幸福度」の客観学標価II -ライフスタイルならびに認知・行動機能との関連-" 日本老年医学会雑誌. 29. 817-822 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松林 公蔵: "″Visual Analogue Scale″による老年者の「主観的幸福度」の客観的標価III -ヒマラヤ地域高所住民への応用-" 日本老年医学会雑誌. 29. 823-828 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] TANAKA,M.: "Dependence of biphasic heart rate response to sastained hypoxia on magnitude of ventilation in man." Jpn J Appl Physiol. 42. 865-875 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 瀬戸 嗣郎: "クムジュン・カトマンズ・日本における小中学校検診(1) -血圧の比較-" ヒマラヤ学誌. 3. 14-21 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 井上 真: "クムジュン・カトマンズ・日本における小中学校検薩診(2) -Anthropometryの比較-" ヒマラヤ学誌. 3. 22-25 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 杉江 知治: "ネパール高所住民の胃十二指腸病変" ヒマラヤ学誌. 3. 26-28 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 藤沢 道子: "ナムチェバザールとフンザの住民における「健康度」の比較" ヒマラヤ学誌. 3. 29-30 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 井上 有史: "クンブ地域での精神医学見聞" ヒマラヤ学誌. 3. 31-39 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 上野 吉一: "シェルパの上活と匂い" ヒマラヤ学誌. 3. 40-51 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 河合 明宣: "シェルパ村落経済の変客" ヒマラヤ学誌. 3. 52-61 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 月原 敏博: "チベットの歴史的移動・定着に関する考察 -ソル〜クンブとブータンの観察から-" ヒマラヤ学誌. 3. 62-72 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 古川 彰: "援助調査プロジェクトと住民の環境問題 -ヒマラヤ高地住民の環境認識ノート-" ヒマラヤ学誌. 3. 73-82 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 野田 智子: "フンザ4ケ村における血圧・年齢相関の比較" ヒマラヤ学誌. 3. 88-90 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 内田 一茂: "老年者の神経行動機能の標価に用いた指標のValidityに関する検討" ヒマラヤ学誌. 3. 91-94 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松林 公蔵: "フンザ医学調査における文化人類学的考察 -フンザと高知県香北町の老年者に関する比較検討-" ヒマラヤ学誌. 3. 95-105 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 宮本 寛: "フンザにおける水質調査" ヒマラヤ学誌. 3. 106-109 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 江本 博文: "フンザ・カラコラム医学学術調査における電源供給について" ヒマラヤ学誌. 3. 110-112 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 堀 了平: "ブータンの生薬資源" ヒマラヤ学誌. 3. 113-122 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松林 公蔵: "高所登山における副交感神経機能について" ヒマラヤ学誌. 3. 129-132 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 月原 敏博: "ブータン・ヒマラヤにおける生業様式の垂直構造" ヒマラヤ学誌. 3. 133-176 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松林 公蔵: "カラコルム医学学術調査研究概要" ヒマラヤ学誌. 3. 83-87 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 瀬戸 嗣郎: "第3次ネパール・クンブ医学学術調査研究概要" ヒマラヤ学誌. 3. 7-13 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Incidental brain lesion on magnetic resonance imaging and neurobehavioral functions in the apparently healthy elderly." Stroke. 23. 175-180 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Evaluation of subjective Happiness in the Elderly Using a Visual Analogue Scale of Happiness in Correlation with Depression Scale." Jpn J Geriat. 29. 811-816 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Evaluation of Subjective Happiness in the Elderly Using a Visual Analogue Scale of Happiness to Analyze the Effect of Life Style and Neurobehavioral Function on Subjective Happiness." Jpn J Geriat. 29. 817-822 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Application of Visual Analogue Scale of Happiness to Elderly Himalayan Highlanders." Jpn J Geriat. 29. 823-828 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka, M.: "Dependence of biphasic heart rate response to sastained hypoxia on magnitude of ventilation." Jpn J Appl Physiol. 42. 865-875 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Inoue, M.: "Physical Examination of Elementary School and Junior High School Children in Kumjung, Kathmandu, Japan (2) ; Comparison of Anthropometrical Data." Himalayan Study Monographs. 3. 22-25 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sugie, T.: "Gastro-duodenal Lesion of Nepalese Highlanders." Himalayan Study Monographs. 3. 26-28 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujisawa, M.: "Comparison of "Health" in Five Villages in Himalaya." Himalayan Study Monographs. 3. 29-30 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Inoue, V.: "Some Psychiatric Observations in the Khumbu Area." Himalayan Study Monographs. 3. 31-39 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ueno, Y.: "Odor in Sherpa's life" Himalayan Study Monographs.3. 40-51 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Seto, S.: "Physical Examination of Elementary School and Junior High School Children in Kumjung, Kathmandu, Japan (1) ; Comparison of Blood Pressure." Himalayan Study Monographs. 3. 14-21 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kawai, A.: "Change in the Sherpa Society : Impacts of Trekking-Tourism." Himalayan Study Monographs. 3. 52-61 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tsukihara, T.: "Forest as "No Man's Land" for Cultural Tibetans : Historical Process of Migration to Solu-Khumbu and Bhutan." Himalayan Study Monographs. 3. 62-72 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Furukawa, A.: "A Result of Aid Projects and Environmental Problem in Namche Bazar." Himalayan Study Monographs. 3. 73-82 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Noda, T.: "The Comparison of Relationship between Blood Pressure and Age in 4 Villages in Hunza." Himalayan Study Monographs. 3. 88-90 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uchida, K.: "Validity of Index of Neurobehavioral Functional Assessment in Elderly." Himalayan Study Monographs. 3. 91-94 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Ethnoanthropological Aspect of Medical Research of Elderly People in Hunza." Himalayan Study Monographs. 3. 95-105 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Miyamoto, H.: "Comparison of Water Analysis between Kochi in Japan and Hunza in Pakistan." Himalayan Study Monographs. 3. 106-109 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Emoto, H.: "Power Supply System for Medical Research Expedition to Hunza, Karakorum." Himalayan Study Monographs. 3. 110-112 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hori, R.: "Medicinal Plants Resources of Bhutan." Himalayan Study Monographs. 3. 113-122 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Parasympathetic Nervous Function at High Altitude Climbing in Bhutan Himalaya" Himalayan Study Monographs. 3. 129-132 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tsukihara, T.: "Vertically Organized Structure of Subsistence Economies in Bhutan." Himalayan Study Monographs. 3. 133-176 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi, K.: "Outline of Medical Research of Elderly in Hunza in Karakoram" Himalayan Study Monographs. 3. 83-87 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Seto, S.: "A Comprehensive Report of the Third Medical and Sociological Field-work in Khumbu District of Nepal" Himalayan Study Monographs. 3. 7-13 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi K.: "Incidental brain bsion on magnetic resenanu imaging and neurobe havioral furctions in the appanertly herethy elderly" Stroke. 23. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松林 公蔵: "“Visual Analogu Scale"による老年者の「主観的幸福度」の客観的評価:IIIーヒマラヤ地域高所住民への応用ー" 日本老年学会雑誌. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 平田 和男: "高所における左心室機能と左心室の壁運動の変化 ー心臓超音波断層装置を用いてー" ヒマラヤ学誌. 2. 75-80 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 杉江 知治: "高所における胃十二指腸粘膜病変" ヒマラヤ学誌. 2. 97-102 (ナルルナ)

    • Related Report
      1991 Annual Research Report
  • [Publications] Masuyama S.: "Respiratory response to acute hypobaric hypoxia" Jap.J.Hypabaric Med.25(3). 119-127 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Masuyama S.: "Altitude acclimatization on and hypoxic uentilatory response" Am.Res.Respir.Dis.142(4). A764 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松林 公蔵: "長寿伝説の里" 高知新聞企業 出版部, 1-271 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松沢 哲郎: "チンパンジ-・マインド 心と認識の世界" 岩波書店, 1-265 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1990-04-01   Modified: 2018-02-02  

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