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Investigation on a cooperative development of stratergy on curative treatment of leukemia with Federal Republic of Germany

Research Project

Project/Area Number 02042003
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionNagoya University

Principal Investigator

OHNO Ryuzo  Nagoya University Department of Medicine・Associate Professor, 医学部, 助教授 (70093002)

大野 龍三 (1991)  名古屋大学, 医学部, 助教授

Co-Investigator(Kenkyū-buntansha) RIEHM Hansjog  Hanover University Department of Medicine・Professor, 医学部, 教授
BUCHNER Thomas  Munster University Department of Medicine・Professor, 医学部, 教授
TOMONAGA Masao  Nagasaki University Department of Medicine・Professor, 医学部, 教授 (40100854)
FUJIMOTO Takeo  Aichi Medical University Department of Medicine・Professor, 医学部, 教授 (10037442)
RIEM Hansjog  ハノーバー大学, 医学部, 教授
BUCHUER Thom  ミュンスター大学, 医学部, 教授
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsFederal Republic of Germany / Leukemia / Cooperative study / University of Munster / Hannover Medical School / Chemotherapy / FAB classification
Research Abstract

Federal Republic of Germany (FRG) now leads the world in the field of leukemia therapy. The strategy of curative intensive therapy and the number of patients involved in their nation-wide clinical studies surpass those of U. S. A or other parts of Europe. The rapid rise of quality and quantity of their clinical studies of leukemia has derived from government-supported funds for the war against cancer which started in 1979. Their concept was characterized by the emphases on the role of biostatistics in planning of protocols and the analysis of data, and 5 biostatistc centers were established throughout FRG. Unlike in U. S. A, , FRG government did not support to establish oncology groups, but formed project teams on each cancer. Each project team receives approximately 20 to 50 x 10^6 Yen per year for about 5 to 7 years. For example, in the fields of adult leukemia, there are 3 project teams ; acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia, and they receive in total about 4 to 7 times of funds compared to those of the project team on adult leukemia in Japan which is supported by the Ministry of Health and Welfare and the official members of which are only up to 12 institutions. Through the present investigation, the reason why FRG has emerged as a super power in the field of clinical cancer study has become clear. FRG government has funded the clinical research as well as basic science in the war against cancer. In Japan, the 10-year war against cancer, which started in 1984, has funded almost exclusively basic research such as biotechnology. To establish high-standard clinical cancer study in Japan, more governmental funds should be distributed to clinical studies, at least to establish biostatistic centers which plan and control the clinical studies.

Report

(2 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (76 results)

All Other

All Publications (76 results)

  • [Publications] R.Ohno,et al.: "Effect of granulocyte colony stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia:a randomized controlled study." New Engl J Med. 323. 871-877 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R.Ohno,et al.: "Intensified induction therapy with behenoyl cytosine arabinoside,daunorubicin,6-mercaptopurine and prednisolone (BHAC-DMP(II)) therapy for acute myelogenous leukemia in adults and prognostic factors related to remission duration." Acta Haematol Jpn. 53. 707-716 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R.Ohno,et al.: "Intensive induction therapy with behenoyl cytosine arabinoside,daunorubicin,and 6-mercaptopurine followed by intensive consolidation with mitoxantrone,etoposide,vincristine,and intermediate-dose continuous cytarabine (M-85 Protocol) for adult acute myelogenous leukemia." Haematol Blood Trans. 33. 304-308 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R.Ohno,et al.: "An early Phase- II study of CPT-11- a new derivative of camptothecin,for the treatment of leukemia." J Clin Oncol. 8. 1907-1912 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S.Osada,et al.: "A case of infantile acute monocytic leukemia caused by vertical transmission of the mother's leukemic cells." Cancer. 65. 1146-1149 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Ezaki,et al.: "Evaluation of the prophylactic effect of oral amphotericin B on fungal infection.-Comparative studies using two dosage regimens-" Acta Haematol Jpn. 53. 103-111 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Tsurusawa,et al.: "Methotrexate cytotoxicity as related to irreversible S phase arrest in mouse L1210 leukemia cells." Jpn J Cancer Res. 81. 85-90 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Shimizu,et al.: "Susceptibility of NB-1 neuroblastoma cells to tumoricidal activity of monocytes activated by γ-interferon." Cancer Res. 81. 1021-1025 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Shimizu,et al.: "Neuroblastoma cell lysis by γ-interferon-activated monocytes from patients receiving chemotherapy." Proceeding Am Association Cancer Res. 31. 245 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Shimizu,et al.: "Childhood acute megakarbovlastic leukemia with internalization of hemic cells." Am J Pediatr Heamatol Oncol. 12. 477-479 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S.Momita,et al.: "Survery of anti human T-cell leukemia wirus type I antibody in family members of patients with adult T-cell leukemia." Jpn J Cancer Res. 81. 884-889 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Tomonaga,et al.: "Loss of endoreduplication as morphogenesis of micromegakaryocytes in myelodysplastic syndrome." Acta Medica Nagasakiensia. 35. 57-62 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ryuzo Ohno,et al.: "Treatment of myelodysplastic syndomes with orally administered 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate." Oncology. 48. 451-453 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Kiyoi,et al.: "Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD." Bone Marrow Transplantation. 8. 59-62 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kohji Ezaki,et al.: "A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma." Cancer. 68. 695-698 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ryuzo Ohno,et al.: "Intensive individualized induction therapy with behenoyl cytarabine,daunorubicin and 6-mercaptopurine followed by intensive consolidation including intermediate-dose continuous cytarabine,mitoxantron,etoposide and vinca alkaloids in acute myeloid leukemia in adults." Inter J Hematol. 54. 487-493 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Kiyoi,et al.: "Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)- III sequences from human B-cell precursor acute lymphoblastic leukemia cells." J Clin Inv. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Murakami,et al.: "Studies on age-dependent plasma platinum pharmacokinetics and ototoxicity of cisplatin." Sel Cancer Ther. 6. 145-151 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S.Koizumi,et al.: "Retrospective analysis of late intennsification tharapy with high dose methotrexate for standard-risk lymphoblastic leukemia in childhood (CCLSGS811 study)." Inter J Hematol. 54. 307-313 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Nigita,et al.: "Characterization of the human IL-5 receptors on eosinophils." Cellular Immunol. 133. 484-497 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y.Yamada,et al.: "IL-2-dependent ATL cell lines with phenotypes differing from the original leukemia cells." Leukemia Res. 15. 619-625 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Nagai,et al.: "Myelodysplastic remission in acute myeloid leukemia:implication for early relapse." Brit J Haematol. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Buchner,et al.: "Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse." Blood. 78. 1190-1197 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Buchner,et al.: "Chemotherapy compared with bone marrow transplantation for adults with acute lymphoblastic leukemia in first remission." Ann Intern Med. 115. 13-18 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] G.Henze,et al.: "Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute iymphoblastic leukemia (ALL-REZ BFM 85),A relapse study of the BFM group." Blood. 78. 1166-1172 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 大野 竜三: "Annual Review 血液 1990" 中外医学社, 86-95 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤本 孟男: "今日の小児診断指針" 医学書院, 244-248 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Tsurusawa,et al.: "Haematology and Blood Transfusion" Springer-Verlag, 174-181 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Ichimaru,et al.: "Atomic bomb and leukemia." J Radiat Res, 162-167 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R. Ohno, et al: "Effect of granulocyte colony stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia : a randomized controlled study." New Engl J Med. 323. 871-877 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R. Ohno, et al.: "Intensified induction therapy with behenoyl cytosine arabinoside, daunorubicin, 6-mercaptopurine and prednisolone (BHAC-DMP (II) ) therapy for acute myelogenous leukemia in adults and prognostic factors related to remission duration." Acta Haematol Jpn. 53. 707-716 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R. Ohno, et al.: "Intensive induction therapy with behenoyl cytosine arabinoside, daunorubicin, and 6-mercaptopurine followed by intensive consolidation with mitoxantorne, etoposide, vincristine, and intermediate-dose continuous cytarabine (M-85 Protocol) for adult acute myelogenous leukemia." Haematol Blood Trans. 33. 304-308 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R. Ohno, et al.: "An early Phase- II study of CPT-11-a new derivative of camptothecin, for the treatment of leukemia." J Clin Oncol. 8. 1907-1912 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Osada, et al.: "A case of infantile acute monocytic leukemia caused by vertical transmission of the mother's leukemic cells." Cancer. 65. 1146-1149 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Ezaki, et al.: "Evaluation of the prophylactic effect of oral amphotericin B on fungal infection. -Comparative studies using two dosage regiments-" Acta Haematol Jpn. 53. 103-111 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Tsurusawa, et al.: "Methotrexate cytotoxicity as related to irreversible S phase arrest in mouse L1210 leukemia cells." Jpn J Cancer Res. 81. 85-90 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Shimizu, et al.: "Susceptibilty of NB-1 neuroblastoma cells to tumoricidal activity of monocytes activated by gamma-interferon." Cancer Res. 81. 1021-1025 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Shimizu, et al.: "Neuroblastoma cell lysis by gamma-interferon-activated monocytes from patients receiving chemotherapy." Proceeding Am Association Cancer Res. 31. 245 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Shimizu, et al.: "Childhood acute megakarbovlastic leukemia with internalization of hemic cells." Am J Pediatr Heamatol Oncol. 12. 477-479 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Momita, et al.: "Survery of anti human T-cell leukemia wirus type I antibody in family members of patients with adult T-cell leukemia." Jpn J Cancer Res. 81. 884-889 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. tomonaga, at al.: "Loss of endoreduplication as morphogenesis of micromegakaryocytes in myelodysplastic syndrome." Acta Medica Nagasakiensia. 35. 57-62 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ryuzo Ohno, et al.: "Treatment of myelodysplastic syndomes with orally administered 1-beta-D-arabinofuranosylcytosine-5'-stearylphosphate." Oncology. 48. 451-453 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Kiyoi, et al.: "Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD." Bone Marrow Transplantation. 8. 59-62 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kohji Ezaki, et al.: "A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma." Cancer. 68. 695-698 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ryuzo Ohno, et al.: "Intensive individualized induction therapy with behenoyl cytarabine, daunorubicin and 6-mercaptopurine followed by intensive consolidation including intermediate-dose continuous cytarabine, mitoxantron, etoposide and vinca alkaloids in acute myeloid leukemia in adults." Inter J Hematol. 54. 487-493 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Kiyoi, et al.: "Characterization of the immunoglobulin heavy chain complementarity determining region (CDR) -III sequences from human B-cell precursor acute lymphoblastic leukemia cells." J Clin Inv. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Murakami, et al.: "Studies on age-dependent plasma platinum pharmacokinetics and ototoxicity of cisplatin." Sel Cancer Ther. 6. 145-151 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Koizumi, et al.: "Retrospective analysis of late intensification therapy with high dose methotrexate for standard-risk lymphoblastic leukemia in childhood (CCLSG-S811 study)." Inter J Hematol. 54. 307-313 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Nigita, et al.: "Characterization of the human IL-5 receptors on eosinophils." Cellular Immunol. 133. 484-497 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Yamada, et al.: "IL-2-dependent ATL cell lines with phenotypes differing from the original leukemia cells." Leukemia Res. 15. 619-625 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Nagai, et al.: "Myelodysplastic remission in acute myeloid leukemia : implication for early relapse." Brit J Haematol. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Buchner, et al.: "Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse." Blood. 78. 1190-1197 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Buchner, et al.: "Chemotherapy compared with bone marrow transplantation for adults with acute lymphoblastic leukemia in first remission." Ann Intern Med. 115. 13-18 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] G. Henze, et al.: "Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute iymphoblastic leukemia (ALL-REZ BFM 85), A relapse study of the BFM group." Blood. 78. 1166-1172 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Tsurusawa, et al.: Springer-Verlag. Haematology and Blood Transfusion., 174-181 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Ichimaru, et al.: J Radiat Res. Atomic bomb and leukemia., 162-167 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R. Ohno: Annual Review Blood 1990. Chugai-Igakusha, 86-95 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Fujimoto: Pediatric Diagnosis Today. Igakushoin, 244-248 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] R.Ohno,et al.: "Effect of granulocyte colony stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia:a randomized controlled study." The New England Journal of Medicine. 323. 871-877 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] R.Ohno,et al.: "Intensified induction therapy with behenoyl cytosine arabinoside,daunorubicin,6ーmercaptopurine and prednisolone (BHACーDMP(II)) therapy for acute myelogenous leukemia in adults and prognostic factors related to remission duration." Acta Haematologica Japonica. 53. 707-716 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] R.Ohno,et al.: "Intensive induction therapy with behenoyl cytosine arabinoside,daunorubicin,and 6ーmercaptopurine follwed by intensive consolidation with mitoxantrone,etoposide,vincristine,and intermediateーdose continuous cytarabine (Mー85 Protocol) for adute myelogenous leukemia." Haematology and Blood Transfusion. 33. 304-308 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] R.Ohno,et al.: "An early Phaseー II study of CPTー11ーa new derivative of camptothecin,for the treatment of leukemia." Journal Clinical Oncology. 8. 1907-1912 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] S.Osada,et al.: "A case of infantile acute monocytic leukemia caused by vertical transmission of the mother's leukemic cells." Cancer. 65. 1146-1149 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Ezaki,et al.: "Evaluation of the prophylactic effect of oral amphotericin B on fungal infection. ーComparative studies using two dosage regimensー" Acta Haematologica Japonica. 53. 103-111 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Tsurusawa,et al.: "Methotrexate cytotoxicity as related to irreversible S phase arrest in mouse L1210 leukemia cells." Jpn J Cancer Res. 81. 85-90 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Shimizu,et al.: "Susceptibility of NBー1 neuroblastoma cells to tumoricidal activity of monocytes activated by γーinterferon." Jpn.J Cancer Res. 81. 1021-1025 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Shimizu,et al.: "Neuroblastoma cell lysis by γーinterferonーactivated monocytes from patients receiving chemotherapy." Proceeding Am Association Cancer Res. 31. 245- (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Shimizu,et al.: "Childhood acute megakarbovlastic leukemia with internalization of hemic cells." Am J Pediatr Heamatol Oncol. 12. 477-479 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Murakami,et al.: "Studies on ageーdependent plasma platinum pharmacokinetics and ototoxicity of cisplatin." Selective Cancer Therapeutics. 33. 174-181 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] S.Momita,et al.: "Survey of anti human Tーcell leukemia virus type I antibody in family members of patients with adult Tーcell leukemia." Jpn J Cancer Res. 81. 884-889 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Tomonaga,et al.: "Low dose cytosine arabinoside regimen for over leukemia,hypoplastic leukemia and myelodysplastic syndromes: Hypoplastic leukemia responds best." Acta Medica Nagasakiensia. in press. (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Tomonaga,et al.: "Loss of endoreduplication as morphogenesis of micromegakaryocytes in myelodysplastic syndrome." Acta Medica Nagasakiensia. in press. (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大野 竜三: "Annual Review 血液 1990" 中外医学社, 86-95 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤本 孟男: "今日の小児診断指針" 医学書院, 244-248 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Tsurusawa,et al.: "Haematology and Blood Transfusion" SpringerーVerlag, 174-181 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Ichimaru,et al.: "Atomic bomb and acute leukemia." WileyーLiss,Inc., 1-8 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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