| Project/Area Number |
02042007
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Kobe Women's College of Pharmacy |
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Principal Investigator |
KATO Atsushi Professor, Kobe Women's College of Pharmacy, 薬学部, 教授 (50068326)
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| Co-Investigator(Kenkyū-buntansha) |
カ゛ッチャシ F.N. ケニア林業研究所, 分類, 技術員
MSHIU E. N. Dar Es Salaam University Director, Traditional Medicine Research Unit., 医学研究所, 部長
OGET J. O. University of Nairobi Associate professor, Department of Pharmacy, 薬学部, 講師
JUMA F. D. University of Nairobi Professor, Department of Medicine, 医学部, 教授
INOHANA Yumi Assistant, Kobe Women's College of Pharmacy, 薬学部, 助手
TACHIBANA Yoko Assistant, Kobe Women's College of Pharmacy, 薬学部, 助手 (20207054)
TOBE Hiroshi Associate professor, Kyoto University, 教養部, 助教授
GACHATHI F. N. Head of Technician, Kenya Forest Institute
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| Project Period (FY) |
1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1990: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Keywords | Anticancer substance / Anticancer component in plant / Antipromotion on EB-virus activation / African ethnic crude drug / Sulfer containing alkaloid / Anticancer indol alkaloid / Rhizophoraceae / Apocynaceae |
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| Research Abstract |
Aims
Many naturally occurring anticancer substances have been isolated from plants and marine products, and also their chemical modification are tried for further effect and safety as medicine in various institutes. Some of these compounds are used as clinical medicines in hospital. Furthermore, study on anticancer substance in natural resources is desired for the future. Therefore, in order to find new anticancer substances in tropical plants, field research in East Africa, especially, in Kenya, Tanzania and Madagascar was carried out by us in 1990.
Methods
1. Research areas
(1) Kenya ; Kakamega, Kaloleni, Shimba hill, Aberdare, the foot of Mt. Kenya, Muguga, Karura forest, Arboretum.
(2) Madagascar ; Foulpointe, Antananarivo market.
(3) Tanzania ; Mpwapwa.
2. Search and collection of natural medicinal plants
(1) For ethnic crude drugs
(a) by oral information or references
(2) For unused medicinal resources
(a) by observation of ecology of plants
(b) by observation of feeding behavior of herbivore
(c) by screening test of others identified taxonomically
Results
A total of 150 species of plants was collected during the research. Among these plants, 15 species are expected to exhibit anticancer activity from results of first screening tests such as inhibition test on EB-virus activation and stimulation index on human peripheral blood lymphocytes and mouse spleen lymphocytes.
For the other species, screening test of anticancer activity will be done to select useful plants.
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