| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Masami School of Medicine, Osaka City University・Professor, 医学部, 教授 (90028316)
金 勇一 ソウル大学, 医科大学, 教授
SHIN Hai Rin College of Medicine, Inje University・Associate Professor, 医科大学, 助教授
KOJIRO Masamichi School of Medicine, Kurume University・Professor, 医学部, 教授 (90080580)
CHOI Ha Chin College of Medicine, Inje University・Professor, 医科大学, 教授
朴 亨鐘 仁濟大学校, 医科大学, 教授
安 允玉 ソウル大学, 医科大学, 助教授
李 孝錫 ソウル大学, 医科大学, 助教授
金 丁竜 ソウル大学, 医科大学, 教授
MITOMA Mutsuko School of Medicine, Fukuoka University・Instructor, 医学部, 助手 (90090737)
KONO Suminori National Defense Medical College・Professor, 教授 (70128015)
HEN Hidetoshi Dept of Surgery, Kyowa Hospital・Head, 外科, 部長
TSUKUMA Hideaki Research Institute, Center for Adult Diseases, Osaka・Chief, 調査部, 係長
HIYAMA. Tomohiko Research Institute, Center for Adult Diseases, Osaka・Head, 調査部, 主幹
PARK Hyung Jong College of Medicine, Inje University・Professor
LEE Hyo Suk College of Medicine, Seoul National University・Associate Professor
AHN Yoon Ok College of Medicine, Seoul National University・Associate Professor
KIM Chung Yong College of Medicine, Seoul National University・Professor
KIM Yong Il College of Medicine, Seoul National University・Professor
季 孝錫 ソウル大学, 医科大学, 助教授
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| Budget Amount *help |
¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1991: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1990: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Research Abstract |
Comparative studies on liver cancer (HCC) among Japanese in Japan (JJ), Koreans in Korea (KK) and in Japan (KJ) revealed some important diffrences between 3 populations.
Descriptive studies showed higher mortality from HCC in KJ, 3 times for males and 2 times, and nearly 2-fold higher incidence rate among KK compared to JJ. Proportions of RBsAg positives were higher among KK and KJ than among JJ. The results suggest the increased risk of HCC among Koreans could be partly attributed to HBV infections.
Results of case-control studies indicate HBV infection is a predominant factor in causation of HCC among KK while HCV infection is more important among JJ. Heavy drinking relates to increased risk in development of HCC among KJ and JJ but riot among KK.
HCC antibody positivity showed interesting defferences. Much higher positivity (71%) was found in JJ HCC patients that KK's (20% in Seoul and 9% in Pusan) and KJ male patient showed similar level to JJ's but female's remained same levels as KK's. Iri healthy persons the positive rates were higher in KJ, 6.6% and 5.7% in Osaka and 12.5% and 6.9% in Fukuoka for males and females respectively than KK in Seoul and JJ (about 1-2%). In Pusan, however, high rate, 5.1% for both sex together, was observed.
Pathological studies showed no remarkable differences in the histology of hepatocellular carcinoma between Koreans and Japanese. However, in Korean specimens more HBsAg positive cancer cells were observed and more and severe liver cell dysplasia was found that in Japanese specimens. Marked association of liver cell dysplasia and serum HBsAg positivity was noticed suggesting strong influence of HBV infection to HCC in Koreans.
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