| Project/Area Number |
02044014
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Tohoku University |
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Principal Investigator |
HARADA Nobuyuki Tohoku University, Institute for Chemical Reacti, 反応化学研究所, 教授 (30006324)
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| Co-Investigator(Kenkyū-buntansha) |
BENJAMIN ROD Spain国立研究所, 有機化学研究所(スペイン), 教授
JACEK GAWRON Adam Mickiewicz大学, 化学教室(ポーランド), 教授
BLACK David St C. New South Wales University Department of Chemistry (Australia), 化学教室(オーストラリア), 教授
KOREEDA Masato University of Michigan Department of Chemistry (USA), 化学教室(アメリカ), 教授
NIZAM U.D. K Aligarh Muslim大学, 化学教室(インド), 講師
NIKOLINA D. Bulgria科学アカデミー, 有機化学研究所(ブルガリア), 研究員
DAVID A. LIG Nevada大学, 化学教室(アメリカ), 教授
BEN L. FERIN Groningen大学, 化学教室(オランダ), 教授
NAKANISHI Koji Columbia University Department of Chemistry (USA), 化学教室(アメリカ), 教授
RODRIGUEZ Benjamin CSIC,Institute of Organic Chemistry (Spain)
GAWRONSKI Jacek Adam Mickiewicz University Department of Chemistry (Poland)
KHAN Nizam U.D. Aligarh Muslim University Department of Chemistry (India)
LIGHTNER David A. University of Nevada, Reno Department of Chemistry (USA)
BEROVA Nikolina D. Bulgaria Academy of Science Institute of Organic Chemistry (Bulgaria)
FERINGA Ben L. Groningen University Department of Chemistry (Netherlands)
GAWRONSKI Ja Adam Mickiewicz大学, 化学教室(ポーランド), 教授
BLACK David New South Wales大学, 化学教室, 教授
KASHMAN Yoel Tel Aviv大学, 化学教室(イスラエル), 教授
DUTTA Pradee インド化学生物学研究所(インド), 研究員
SNATZKE Gunt Ruhr大学, 化学教室(ドイツ), 教授
BEROVA Nikol Bulgaria科学アカデミー, 有機化学研究所(ブルガリア), 研究員
SANDSTROM Ja Lund大学, 化学センター(スウェーデン), 教授
FERINGA Ben Groningen大学, 化学教室(オランダ), 教授
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 1992: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1991: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1990: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | CD Spectra / CD Exciton Chirality Method / Twisted pi-Electron Systems / Absolute Stereochemistry / Atropisomeric Biflavone / Biscyanine Dye / Absolute Stereostructures of Acyclic Polyols / Chiral Spiro Compounds / CD励起子カイラリティ-法 / 鎖状ポリオ-ルの絶対構造 / [6,6]ーベスピレン / 円二色性スペクトル / 励起子相互作用 / X線結晶構造解析 / 光学活性パイ電子系化合物 / 分子不斉オレフィン / シアニン化合物 |
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| Research Abstract |
The CD spectroscopic method, together with the X-ray crystallographic method, is useful for determination of the absolute stereostructure of chiral organic compounds. We have proposed, as an extension of the CD exciton chirality method, a new theoretical method for nonempirical determination of the absolute stereochemistry of twisted pi-electron systems. The CD spectra can be theoretically calculated by the pi-electron SCF-CI-DV molecular orbital method, and we have determined the absolute stereostructures of the following biologically active natural products and synthetic chiral organic compounds with theoretical interest.
1.The electronic structure of rho-methoxycinnamate chromophore suitable for application of the CD exciton chirality method to oligosaccharides was clarified.
2.absolute stereochemistry at C-12 in 12-hydroxylated neo-clerodane diterpenoids was determined by CD and X-ray methods.
3.Chiral olefins with molecular asymmetry were synthesized, and their absolute stereostructu
… More
res were determined by the CD method. the kinetics and mechanism of their photo and thermal racemization were also clarified.
4.CD and absolute stereochemistry of chiral bridged biphenyls were studied.
5.We found that a chiral biscyanine dye exhibits unusually strong exciton split in UV-VIS absorption and CD spectra, and the origin and nature of its unique exciton coupling behavior were clarified.
6.We developed a CD exciton method for determination of the absolute stereochemistry of acyclic 1,3-dibenzoate systems.d the origin and nature of its unique exciton coupling behavior were clarified.
7.Chiral spiroaromatic compounds with 9,9'-spirobifluorene skeleton including[6,6]-vespirene were synthesized and their absolute stereostructures were determined by the CD method.
8.We have succeeded in the first determination of the absolute stereochemistry of atropisomeric biflavone, (-)-4',4''',7,7''-tetra-O-methylcupressuflavone, by theoretical calculation of CD spectra.
9.A chiral probe useful for optical resolution and X-ray crystallographic determination of the absolute stereochemistry of chiral carboxylic acids was developed.
10.We revised, by X-ray crystallographic and CD spectral studies, the absolute stereochemistry of (8)-and(10)-paracyclophane carboxylic acids previously erroneously determined on the basis of chemical correlation. Less
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