| Project/Area Number |
02044095
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Osaka University |
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Principal Investigator |
MORIWAKI Kaname Oska University Medical School, Associate Professor, 医学部, 助教授 (90028548)
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| Co-Investigator(Kenkyū-buntansha) |
B.GRONER スイス, サードウィヒ癌研究所, 研究員
E.SLATER ドイツ, 分子遺伝学・癌研究所, 研究員
S.S.SIMONS 米国国立衛生研究所, 主任研究員
G.P.CHROUSOS 米国国立衛生研究所, 主任研究員
W.B.PRATT ミレガン大学, 医学部, 教授
E.AUBREY Tho テキサス大学, 医学部, 助教授
E.BRD Thomps テキサス大学, 医学部, 教授
FUJII Hiroshi Osaka University Medical School, Senior Resident, 医学部附属病院, 医員
HANAHUSA Toshiaki Osaka University Medical School, Assistant, 医学部, 助手 (60164886)
IIDA Sayomi Osaka University Medical School, Assistant, 医学部, 助手 (40159554)
GRONER B. Ludwig Institute for Cancer, Senior Investigator
SIATER E. Molecular Genetics and Cancer Institute, Researcher
SIMONS S. S. National Institute of Health, Senior Investigator
CHROUSOS G. P. National Institute of Health, Senior Investigator
PRATT W. B. University of Michigan, Medical School, Professor
THOMPSON E. A. Texas University Medical Branch, Associate Professor
THOMPSON. E. B. Texas University Medical Branch, Professor
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| Project Period (FY) |
1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1990: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | glucocorticoid receptor gene / glucocorticoid receptor / cortisol resistance / cortisol hyperreactive syndrome / receptor abnormality |
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| Research Abstract |
We have reported the second family in the world of cortisol resistance with decreased numbers of glucocorticoid receptors (GR). In peripheral lamphocytes of the patients, we found that concentrations of GR were decreased to about one half of normals. Similar findings were made for cultured skin fibroblasts and E-B virus transformed lymphocytes of the patients. These findings indicated that the decrease in the numbers of GR was the principal cause of cortisol resistance in the family. In order to further investigate into the genetical basis for the abnormality, we started a cooperative studies with the most active scientists in the field of molecular biology of GR.
We have exchanged research information with Prof. E. B. Thompson,the leading member of this study, in Atlanta, Georgia, U. S. A. at American Endocrine Society held on June 16-18, 1990. We also made communications with Dr. E. Slater, Molecular Biology and Cancer Institute, Germany, during my visit to Europe to attend the 8th International Congress on Hormonal Steroids, where I have presented our paper.
More recently, We reported on a patient with cortisol hyperreactive syndrome. This is the first description of a patient who is hyperreactive to the hormone and provides a unique view point in the field of endocrinology.
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