| Project/Area Number |
02044168
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | National Institute of Health |
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Principal Investigator |
KAGEI Noboru Department of Parasitology, National Institute of Health, 寄生虫部, 室長
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| Co-Investigator(Kenkyū-buntansha) |
MINAI Masaru Yamanashi Prefectural Institute for Public Health, 専門研究員
SHO Masanori Yamanashi Medical College, 助手 (90154682)
OHTA Nobuo School of Medicine, Okayama University, 助教授 (10143611)
KAMO Etsuji Koma Kyouritsu Hospital, 院長
HOSAKA Yukio Department of Parasitology, National Institute of Health, 寄生虫部, 客員研究員 (60072873)
KOYAMA Tsutomu Department of Parasitology, National Institute of Health, 寄生虫部, 客員研究員 (70072874)
GANG Feng Xin Hunan Institute of Parasitic Diseases
MING Pu Kai Hunan Institute of Parasitic Diseases
REN Zhou Da Hunan Institute of Parasitic Diseases
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| Project Period (FY) |
1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1990: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Schistosomiasis japonica / Dong-ting lake / Epidemiology / Immunopathology / Seroepidemiology / Idiotypic antibodies / Praziquantel / Control of snail intermediate host |
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| Research Abstract |
To analyze the epidemiological situation, three kinds of schistosomiasis foci, the areas in low prevalent phase (A) and (B) and the area in high prevalent phase (C) in the endemic area around the Dong-ting Lake, were selected. Prevalences of the disease were 20.6% and 18.9% in the two foci (A) and (B), respectively, but about 50% in the focus (C). In the foci (A) and (B), the positive rate was high among the people engaged in agriculture, whereas fishermen and pupils in the focus (C) were highly positive on faecal examination. The relation between the number of eggs per faeces and the symptoms was clearly significant. The disease was also found at high prevalence rate in some domestic animals such as cattle, pigs, dogs and cats. The need for managing the infected animals under the control measures should be stressed.
We investigated the change of serum antibodies in patients treated with Praziquantel. The data suggested that the successful treatment resulted in remarkable decrease of the antibody titer. The tests for serum antibody by highly specific techniques such as ELISA and Western-Blotting seemed useful for evaluation of the effect of the treatment and for seroepidemiological analysis.
We studied IgG idiotypes in sera of schistosomiasis patients in China for evaluating anti-idiotypic T cell response in vitro. There was a heterogeneity in appearance of functional idiotypes in infected sera, and the idiotypic activities were independent of treatment and antibody-titers to schistosome egg. Those results suggest that idiotypic activities might give an unique information showing the clinical difference of schistosomiasis japonica.
For the purpose of vector snail control, protozoan parasites of the snail were investigated but the pathogenic ones were not found. Molluscicidal effects of some agricultural drugs were tested on the snials. The results suggest that Cartap and Tribromosalan seem to be potential molluscicides for the control of the snails
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