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Integrative Control of Respiratory and Circulatory Functions with Special Reference to Baro- and Chemo-Receptor Activities

Research Project

Project/Area Number 02044174
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
Research InstitutionChiba University

Principal Investigator

HONDA Yoshiyuki  Department of physiology, School of Medicine, Chiba University, 医学部, 教授 (30019525)

Co-Investigator(Kenkyū-buntansha) BLAKEMORE Collins  University Laboratory of Physiology, University of Oxford, United Kingdom, 生理学研究所, 所長
NYE Piers G.  University Laboratory of Physiology, University of Oxford, United Kingdom, 生理学研究所, 講師
ROBBINS Peter  University Laboratory of Physiology, University of Oxford, United Kingdom, 生理学研究所, 講師
SAITO Toshihiro  Department of Internal Medicine, School of Medicine, Chiba University, 医学部, 講師 (40009593)
MASUDA Atsuko  Department of Physiology, School of Medicine, Chiba University, 医学部, 助手 (70165710)
SAKAKIBARA Yoshikazu  Department of Physiology, School of Medicine, Chiba University, 医学部, 講師 (50092060)
Project Period (FY) 1990
Project Status Completed (Fiscal Year 1990)
KeywordsBaroreceptors / Blood gas / Circulatory and respiratory activities / Hypoxia / Hyperoxia / Brain Blood Flow
Research Abstract

Using a new apparatus to induce stimulation for the carotid baroreceptors (Neck suction method), effect of alterations of blood gas environment on baroreceptor activity was investigated.
Five different blood gas conditions were used i. e., a. hypoxia(alveolar Po_2, 50 mmHg), b. hyperoxia(alveolar Po_2, 200 mmHg), c. hypercapnia(alveolar Pco_2, 5 mmHg higher than control), d. combination of a and c, and e. combination of b and c. For neck suction, three degrees of negative pressure were applied, i. e., 20, 40 and 60 mmHg. Thus, combination of above conditions made us 15 different experimental procedures.
Main findings obtained were as follows :
1. Effect of baroreceptor stimulation was dominantly seen during expiratory phase.
2. Carbon dioxide stimulus was found to be inhibitory in all experimental conditions.
3. Positive interaction was seen in the effect between hypoxia and hypercapnia.
4. Effect of neck suction attained to be saturated between 40 to 60 mmHg.

Report

(1 results)
  • 1990 Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Honda,Y.and Hashizume,I.: "Evidence for hypoxic depression of CO_2ーventilation response in carotid bodyーresected humans" Journal of Applied Physiology. 70. 590-593 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Honda,Y.: "Depression of CO_2ーventilation response by mild hypoxia in patients with bilateral carotid body resection" Journal of Physiology. 430. 91T (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Honda,Y.: "Hypoxic ventilatory depression and cardiovascular responses to hypoxia in carotid bodyーresected humans" Japanese Journal of Physiology. 41. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakakibara,Y.,et al.: "Effects of lower body negative pressure(LBNP)on the ventilatory chemoーsensitivities to hypoxia and hypercapnia in man" Japanese Journal of Physiology. 41. 580 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakakibara,Y.and Honda,Y.: "Cardiopulmonary responses to static exercise" The annals of physiological anthropology. 9. 153-161 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Honda, Y. and Hashizume, I.: "Evidence for Hypoxic Depression of CO_2-Ventilation Response in Carotid Body-Resected Humans." Journal of Applied Physiology. 70. 590-593 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Honda, Y.: "Depression of CO_2-Ventilation Response by Mild Hypoxia in Patients with Bilateral Carotid Body Resection." Journal of Physiology. 430. 91 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Honda, Y.: "Hypoxic ventilatory depression and cardiovascular response to hypoxia in carotid body-resected humans." Japanese Journal of Physiology. 41. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakakibara, Y., et al.: "Effects of Lower Body Negative Pressure (LBNP) on the Ventilatory Chemosensitivities to Hypoxia and Hypercapnia in Man." 41. 58 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakakibara, Y. and Honda, Y.: "Cardiopulmonary Responses to Static Exercise." The Annals of Physiological Anthropology. 9. 153-161 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary

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Published: 1993-08-12   Modified: 2016-04-21  

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