| Project/Area Number |
02044174
|
|---|
| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
|
| Allocation Type | Single-year Grants |
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
HONDA Yoshiyuki Department of physiology, School of Medicine, Chiba University, 医学部, 教授 (30019525)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
BLAKEMORE Collins University Laboratory of Physiology, University of Oxford, United Kingdom, 生理学研究所, 所長
NYE Piers G. University Laboratory of Physiology, University of Oxford, United Kingdom, 生理学研究所, 講師
ROBBINS Peter University Laboratory of Physiology, University of Oxford, United Kingdom, 生理学研究所, 講師
SAITO Toshihiro Department of Internal Medicine, School of Medicine, Chiba University, 医学部, 講師 (40009593)
MASUDA Atsuko Department of Physiology, School of Medicine, Chiba University, 医学部, 助手 (70165710)
SAKAKIBARA Yoshikazu Department of Physiology, School of Medicine, Chiba University, 医学部, 講師 (50092060)
|
|---|
| Project Period (FY) |
1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Keywords | Baroreceptors / Blood gas / Circulatory and respiratory activities / Hypoxia / Hyperoxia / Brain Blood Flow |
|---|
| Research Abstract |
Using a new apparatus to induce stimulation for the carotid baroreceptors (Neck suction method), effect of alterations of blood gas environment on baroreceptor activity was investigated.
Five different blood gas conditions were used i. e., a. hypoxia(alveolar Po_2, 50 mmHg), b. hyperoxia(alveolar Po_2, 200 mmHg), c. hypercapnia(alveolar Pco_2, 5 mmHg higher than control), d. combination of a and c, and e. combination of b and c. For neck suction, three degrees of negative pressure were applied, i. e., 20, 40 and 60 mmHg. Thus, combination of above conditions made us 15 different experimental procedures.
Main findings obtained were as follows :
1. Effect of baroreceptor stimulation was dominantly seen during expiratory phase.
2. Carbon dioxide stimulus was found to be inhibitory in all experimental conditions.
3. Positive interaction was seen in the effect between hypoxia and hypercapnia.
4. Effect of neck suction attained to be saturated between 40 to 60 mmHg.
|
