• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Information transduction and processing in biological systems

Research Project

Project/Area Number 02045027
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionKagawa Medical School

Principal Investigator

IRINO Shozo (1991-1992)  Kagawa Medical School President, 学長 (50033056)

西田 勇 (1990, 1992)  香川医科大学, 医学部, 教授 (50032842)

Co-Investigator(Kenkyū-buntansha) WANG J.H.  The University of Calgary Professor, 医学部, 教授
WATANABE M.  The University of calgary Dean, 医学部長
MATSUI Hideki  Kagawa Medical School Associate Professor, 医学部, 助教授 (30157234)
HOSOKAWA Kiyoshi  Kagawa Medical School Vice President, 副学長 (70093698)
HATASE Osamu  Kagawa Medical School Professor, 医学部, 教授 (50033220)
板野 俊文  香川医科大学, 医学部, 助手 (60145042)
細見 弘  香川医科大学, 医学部, 教授 (70030864)
WANG Jerry H  カルガリ大学, 医学部, 教授
WATANABE Mo  カルガリ大学, 医学部, 医学部長
入野 昭三  香川医科大学, 医学部, 教授 (50033056)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1992: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1990: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsInternational Exchange Program / Seminar / Information Transduction System / セミナ-開催
Research Abstract

The human body consists of numerous number of single cells. The communication mechanisms of the biological information in inter- and intra-cellular levels are very important for maintaining the living organisms in physiological conditions. For this communication, numbers of physiological active substances such as hormones, neuro-transmitters, growth factors and so on have important physiological roles. The imbalance and dysfunction of these cross talk factors will lead to various kings of diseases. We have studied the biological information transduction and processing mechanism in collaboration with University of Calgary, Faculty of Medicine in Canada under this grant.
Dr.Irino and Dr.Matsui visited the University of Calgary, Faculty of Medicine to do collaborative works with the scientists in the University of Calgary and also to discuss with the international medical cooperation committee of the University of Calgary on the future plan of the program. The complete agreement between Kagawa side and Calgary side has been made to expand it further in long term scale. Dr.Smith, the newly appointed Dean of Faculty of Medicine, the University of Calgary accepted our invitation to the Kagawa Medical School in April, 1993. Dr.Irino and Dr.Mastui also visited Dr.Mandin, Vice Dean of Clinical Education to discuss on curriculum reformation in the Kagawa Medical School and in the University of Calgary.
Dr.Wang visited the Kagawa Medical School In November, 1992 to do collaborative work on new tyrosine kinase in brain. He was awarded honorable Doctor of Philosophy of the Kagawa Medical School.
Dr.Hatase visited Faculty of Medicine, the University of Calgary on March of 1993 to discuss in detail with the international cooperation committee of the University of Calgary on the definite plan for the future.

Report

(3 results)
  • 1992 Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] T.TAOKA: "Induction of differentiation of HL60 cells by protein kinase Cinhitor,K252a." Biochem.Biophys.Res.Commun.170. 1151-1156 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.TSUBOI: "Inhibitoin of platelet aggregation by s-(1,2-dicarboxyethyl)-glutathione,intringic tripeptide in liver,heart and lens." Arch.Biochem.Biophys.279. 1100-1101 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] F.YAMAGUCHI: "Insulin like growth factor I(IGF-I)distribution in the tissue and extracellular compartment in different regions of rat brain." Brain Res.533. 344-347 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.HATA: "Induction of erythroid differentiation of k562 cells by 4-carbamoylimidazolium 5-olate." Biochem.Pharmacol.42. 2307-2312 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.KUBOTA: "Monoclonal antibodies raised against K562 cells reacted with human haematopoietic pluripotent stem cells." Leukemia Res.15. 195-204 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] F.YAMAGUCHI: "Increase of extracellular insulin-like growth factor I(IGF-I)concentration following electrolytical lesion in rat hippocampus." Neurosci.Lett.128. 273-276 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.NISHIO: "Identification of testis specific calcineurin β subunit isoform by a monoclonal antibody and detection of a specific six amino acid sequence." Biochem.Biophys.Res.Commun.182. 34-38 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.-C.CHENG: "A Synthetic peptide derived from p34^<cdc2> is a specific and efficient substrate of src-family tyrosine kinases." J.Biol.Chem.267. 9248-92 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.MINAMOTO: "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Res.573. 345-348 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] L.J.M.P.Moia: "Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study." Brain Res.585. 283-286 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.NISHIO: "The evidence for post-meiotic expression of a testis-specific isoform of a regulatory subunit of calcineurin using a monoclonal antibody." Biochem.Biophys.Res.Commun.187. 828-831 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.MIYAMOTO: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat." Brain Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.MIZOGUCHI: "Alzheimer's and Parkinson's Disease" Plenum Press., 485 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Taoka: "Induction of differentiation of HL60 cells by protein kinase C inhibitor, K252a." Biochemical Biophysical Research Communication. 170. 1151-1156 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tsuboi: "Inhibition of platelet aggregation by s-(1,2-dicarboxyethyl)-glutathione, intringic tripeptide in liver, heart and lens." Archiv Biochemistry Biophysics. 279. 1100-1101 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] F.Yamaguchi: "Insulin-like growth factor I(IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain." Brain Research. 533. 344-347 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Hata: "Induction of erythroid differentiation of K562 cells by 4-carbamoylimidazolium 5-olate." Biochemical Pharmacology. 42. 2307-2312 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Kubota: "Monoclonal antibodies raised against K562 cells reacted with human haematopoietic Pluripotent stem cells." Leukemia Research. 15. 195-204 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] F.Yamaguchi: "Increase of extracellular insulin-like growth factor I(IGF-I) concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Nisio: "Identification of testis specific calcineurin beta subunit isoform by a monoclonal antibody and detection of specific a six amino acid sequence." Biochemical Biophysical Research Communication. 182. 34-38 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.-C.Cheng: "A Synthetic peptide derived from p34x^<cdc2> is a specific and efficient substrate of src-family tyrosine kinases." Journal of Biological Chemistry. 267. 9248-9256 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Minamoto: "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Research. 573. 345-348 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] L.J.M.P.Moia: "Indentification of a src-family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study." Brain Research. 585. 283-286 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Nisio: "The evidence for post-meiotic expression of a testis-specific isoform of a regulatory subunit of calcineurin using monoclonal antibody." Biochemical Biophysical Research communication. 187. 828-831 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Miyamoto: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat" Brain Research.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Mizobuchi: Plenum Press. Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease, vol. 1, 491-494 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yuki Hata: "Induction of erythroid differentiation of k562 cells by 4-carbamoylimidazolium 5-olate." Biochemical Pharmacology. 42. 2307-2312 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yoshitsugu Kubota: "Monoclonal antibodies raised against K562 cells reacted with human haematopoietic pluripotent stem cells." Leukemia Research. 15. 195-204 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Heung-Chin Cheng: "A Synthetic peptide derived from p34^<cdc2> is a specific substrate of src-family tyrosine kinases." Journal of Biological Chemistry. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hajime Nishio: "Indentification of testis specific calcineurin β subunit isoform by a monoclonal antibody and detection of specific six amino acid sequence." Biochem.Biophys.Res.Commun.182. 34-38 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fuminori Yamaguchi: "Increase of extracellular insulin-like growth factor I(IGF-I)concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yuichiro Minamoto: "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Research. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 畠瀬 修ら: "Induction of differentiation of HL60 cells by protein kinase C inhibitor,K252a." Biochem.Biophys.Res.Commun.170. 1151-1156 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 畠瀬 修ら: "Inhibition of platelet aggregation by sー(1,2ーdicarboxyethyl)ーglutathione,intringic tripeptide in liver,heart and lens." Arch.Biochem.Biophys.279. 146-150 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 入野 昭三ら: "Reversal of enzymic phenotype of thymidine metabolism in induced differentiation of HLー60 cells." Leukamia Res.13. 1123-1129 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 入野 昭三ら: "Reversal of enzymic phenotype of thymidine metabolism in induced differentiation of Uー937 cells." Cancer Res.49. 6758-6763 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 入野 昭三ら: "Decreased accumulation as a mechanism of resistance to cisーdiamminedichloroplatinum(II) in human nonーsmall cell lung cancer cell lines: relation to DNA damage and repair." Cancer Res.50. 2549-2553 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 細川 清ら: "Insulin like growth factor I(IGFーI)distribution in the tissue and extracellular compartment in different regions of rat brain." Brain Res.533. 344-347 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 畠瀬 修ら: "Bioinformatics" Elsevir Publishers, 4 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 畠瀬 修ら: "Alzheimer's and Parkinson's Disease" Plenum Press., 4 (1990)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi