| Project/Area Number |
02303014
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
反応工学
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| Research Institution | Nagoya University |
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Principal Investigator |
KOBAYASHI Takeshi Nagoya Univ., Dept. of Biotechnology, Professor, 工学部, 教授 (10043324)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Tatsuro Kanazawa Univ., Dept. of Chem. Eng., Professor, 工学部, 教授 (80019728)
UNNO Hajime Tokyo Institute of Technol., Dept. of Bioeng., Professor, 生命理工学部, 教授 (10087471)
NAKAMURA Kouzou Gunma Univ., Dept. of Biochem. Eng., Professor, 工学部, 教授 (50011036)
FURUSAKI Shintaro Univ. of Tokyo, Dept. of Chem. Eng., Professor, 工学部, 教授 (40011209)
YAMANE Tsuneo Nagoya Univ., Dept. of Food Sci. Technol., Professor, 農学部, 教授 (70026102)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 1991: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1990: ¥6,300,000 (Direct Cost: ¥6,300,000)
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| Keywords | bioreactor / reactor for animal and plant cells / non-aqueous enzymatic reaction / membrane-type reactor / bioproducts / efficient production / 工業生産 / 膜分離操作 / 動植物細胞 |
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| Research Abstract |
Recently biotechnology including recombinant gene technology and cell fusion has been rapidly progressed. This progress was strongly supported by the comprehensive knowledge of the genetic and biological background. However, extensive studies are essential for practical application of biotechnology in industrial scale. The application of bioreactor with immobilizing enzymes, microorganisms, plant and animal cells will be more important in near future. Therefore, an intensive cooperative research is necessary for making progress in this field.
In this research we achieved new progresses and systematic technology in this field. This research consisted of 4 research groups whose leaders have been an authority in their research fields. We pursued a new possibility and systematic investigation from 1990 to 1991.
1. Development of bioreactor for plant and animal cells : for an efficient production of pharmaceutical or useful products, the simplification of cell immobilization, continuous secretion system of bioproducts, removal system of inhibitory metabolites were developed.
2. Development of new bioreactor : suitable system for an important enzymatic reaction and an improvement of enzyme were performed.
3. Production of substances in non-aqueous solvent system : efficient production system of useful substances, for example aspartame, by an enzyme reaction in non-aqueous solvent system or by using powder enzyme were established.
4. Bioreactor coupled with membrane separation : the mass production system of biochemicals including lactic acid and acetic acid were developed by combining a biochemical reaction and a rapid progress of membrane separation.
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