| Project/Area Number |
02303017
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
SHIOIRI Takayuki Faculty of Pharmaceutical Sciences, Nagoya City University, Professor, 薬学部, 教授 (20012627)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Yasumasa Faculty of Pharmaceutical Sciences, Nagoya City University, Associate Professor, 薬学部, 助教授 (90117846)
YONEMITSU Osamu Faculty of Pharmaceutical Sciences, Hokkaido University, Professor, 薬学部, 教授 (60001038)
KAWAZOE Yutaka Faculty of Pharmaceutical Sciences, Nagoya City University, Professor, 薬学部, 教授 (80106252)
IKEGAMI Shiro Faculty of Pharmaceutical Sciences, Teikyo University, Professor, 薬学部, 教授 (10119555)
ARATA Yoji Faculty of Pharmaceutical Sciences, University of Tokyo, Professor, 薬学部, 教授 (40011499)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1991: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1990: ¥6,800,000 (Direct Cost: ¥6,800,000)
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| Keywords | Biologically active compounds / Efficient synthesis / Structures / Peptides / Sugars / Macrolides / Design of drugs / Physicochemical approach / 物理化学的アプロ-チ / 効率的合成法 |
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| Research Abstract |
The purpose of this research project is as follows : (1) exploitation of efficient synthetic methods for biologically active compounds, (2) identification of the molecular structures which are essential to exhibit biological activities of the compounds, (3) clarification of life of animals and plants on molecular levels, and (4) design of new biologically active compounds useful for human life. The research groups have consisted of 16 professors and the research projects have been divided into four : (1) investigations of biologically active peptides on their synthetic methods and on the structures responsible for their biological activities, (2) investigations of sugars and macrolides on their synthetic methods and on the structures responsible for their biological activities, (3) development of drugs useful for the treatment of diseases on circulatory organs and central nervous system in addition to development of anticancer drugs, and (4) investigations on structures responsible for biological activities by the physicochemical methods. We have successfully pursued all of these projects, and our projects ended to have a great promise of the future development on the syntheses and design of structures of biologically active compounds.
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