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Molecular population genetical studies of evolution.

Research Project

Project/Area Number 02304001
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 遺伝学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

YAMAZAKI Tsuneyuki  KYUSHU UNIV. SCIENCE, PROFESSOR, 理学部, 教授 (10108649)

Co-Investigator(Kenkyū-buntansha) ISHIWA Sadao  OCHANOMIZU UNIV. SCIENCE, PROFESSOR, 理学部, 教授 (20017205)
TOBARI Yoshiko  TOKYO METROPOLITAN UNIV. SCIENCE, PROFESSOR, 理学部, 教授 (20087125)
TAKAHATA Naoyuki  THE GRADUATE UNIV. FOR ADVANCED STUDIES, PROFESSOR, 生命科学研究科, 教授 (30124217)
OHTA Tomoko  NATIONAL INSTITUTE OF GENETICS, PROFESSOR, 集団遺伝系, 教授 (80000256)
KIMURA Motoo  NATIONAL INSTITUTE OF GENETICS, HONORARY PROFESSOR, 集団遺伝系, 名誉教授 (20000226)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥24,800,000 (Direct Cost: ¥24,800,000)
Fiscal Year 1992: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1991: ¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 1990: ¥10,200,000 (Direct Cost: ¥10,200,000)
Keywordsmolecular evolution / adaptive evolution, / molecular population genetics / multigene family / mutation rate / ショウジョウバエ / 分子進化 / 集団遺伝学 / 調節遺伝学 / DNA多型 / 系統樹 / 中立モデル / MHC / トランスポゾン / ミトコンドリアDNA / 多重遺伝子 / MHC遺伝子
Research Abstract

Recent progress in molecular biology has brought a large impact on the study of evolution. In the present project, we investigated the amount of polymorphisms and structures and changes of genes at the molecular level using Drosophila (Yamazaki,Tobari,Ishiwa,Kusakabe and Takano) and wild plants (Miyashita) as model organisms. These studies have revealed various aspects of molecular evolution. As many previous studies had shown, most molecular data are compatible with the neutral theory of molecular evolution proposed by Kimura in 1968 which states that most gene substitutions at the molecular level are due to random fixations of selectively neutral mutations. However, by selecting genes, period (behavior) and amylase (inducible), which are directly involved in organismal response to the environments, we obtained experimental evidences of adaptive amino acid substitutions especially during speciation. Also Hiroyoshi found interesting phenomena in his study on sex determination factors i … More n house flies and now molecular approaches to clarify this phenomena are in progress. Harada estimated the spontaneous mutation rate of isozyme loci, which is a very important parameter in the study of evolution, to be 7 x 10^<-7> per generation.
As to theoretical studies, much progress was made in the development of the neutral theory (Kimura,Ohta,Tajima,Tachida and Iizuka), the methodology of constructing phylogeny (Tajima), evolutionary theories of multigene families and repeated sequences (Ohta and Tachida) and studies on the maintenance mechanisms of polymorphisms (Takahata). In our project, we attempted to understand the molecular mechanisms of adaptive evolution combining theoretical and experimental approaches. Our findings are considered to be landmarks to this new area of molecular evolution which investigates the interrelationships between the phenotypic evolution and the molecular evolution. We now believe that the unified understanding of evolution at both (molecular and phenotypic) levels is within our reach. Less

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] Nitasaka,E.and Yamazaki,T.: "The molecular analysis of brown eye color mutations isolated form geographically discrete populations of Drosophila melanogaster." Proc.Natl.Acod.Sci.USA. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nitasaka,E.and Yamazaki,T.: "The relationship between DNA structural variations and activities of P elements in P and Q strains of Drosophila melanogaster." Genetical Research. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta,T.: "The oretical study of near neutrality.II.Effect of subdivided populaton structure with local extinction and recolonization." Genetics. 130. 917-923 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta,T.: "The meaning of natural selection revisited at the moleculer level." Trends in Ecology and Evolution. 7. 311-312 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahata,N.,Satta,Y.and Klein,J.: "Polymorphism and balancinh selection at major histocompatibility complex loci." Genetics. 130. 925-938 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Morita,T.,Takagata,N.et.al.: "Recent and World-wide introgression to Mus musculus." Proc.Natl.Acad.Sci.USA. 89. 6851-6855 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi,H.,Tobari,Y.N.etal.: "Cytological mappinh of Om mutants of Drosophila ananassae." Jpn.J.Genet.67. 259-264 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kaneko,M.,Satta,Y.,Matsuura,E.T.and Chigusa,S.: "Evolution of the mitochondrial ATP ase 6 gene in Drosophila.:Unusually high level of polymorphism in D.melanogaster." Genetical Research. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Harada,K.,Kusakabe,S.and Mukai,T.: "Comparative study of P element activity in two natural populations of Drosophila melanogaster." Jpn.J.Genet.66. 725-737 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Koga,A.,Harada,K.,Kusakabe,S.and Mukai,T.: "Spontaneous mutations affecting glycerol -3- phosphate dehydrogenase enzyme activity in Drosophila malanogaster." Jpn.J.Genet.67. 125-132 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tachida,H.and Iizuka,M.: "Persistence of repeated seguences that evolve by replication slippage." Genetics.131. 471-478 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Maruyama,K.and Tachida,H.: "Genetic variability and geographical structure in partially selfing populations." Jan.J.Genet.67. 39-51 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima,F.: "Statistical method for estimating the standard errors of branch lengths in a phylogenetics tree reconstructed without assuming egual rates of uncleotide among different lineages." Molecular Biology and Evolution. 9. 168-181 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima,F.: "Statistical nethod for estimating the effective population sezi in pacific salmon." J.of Heredity. 83. 309-311 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kaplan,N.L.,Hudson,R.R.and Iizuka,M.: "The coalescent process in models with selection,recombination and geographic subdivision." Genetical Research Camb.57. 83-91 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tachida,H.and Iizuka,M.: "Fixation probability in spatially changing environments." Genetical Research Camb.58. 243-251 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahata,N.: "The Proceeding of the 17th Taniguchi International Symposium on Biophsics." Japan Scientific Society Press., (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahata,N.: "Molecular Paleopopulation Biology." Japan Scientific Society Press., (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tobari,Y.N.: "Drosophila ananassaeーGenetical and Biological Aspects" Japan Scientific Societics Press., (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 舘田 英典,向井 輝美: "実験集団遺伝学と進化「講座進化6,分子から見た進化」" 東京大学出版会, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nitasaka,E. and Yamazaki,T.: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosophila melanogaster." Proc. Nati. Acad. Sei. USA. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta,T.: "Theoretical study of near neutrality. II. Effect of subdivided population structure with local extinction and recolonization." Genetics. 130. 917-923 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takahata,N., Satta,Y. and Klein,J.: "Polymorphism and balancing selection at major histocompatibility complex loci." Genetics. 130. 925-938 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubayashi,H., Tobari,Y.N. et al.: "Cytological mapping of Om mutants of Drosophila ananassae." Jpn. J. Genet.67. 259-264 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Harada,K., Kusakabe,S. and Mukai,T.: "Comparative study of P element activity in two natural populations of Drosophila melanogaster." Jpn. J. Genet. 66. 725-737 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tachida,H. and Iizuka,M.: "Presistence of repeated sequences that evolve by replication slippage." Genetics. 131. 471-478 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tajima,F.: "Statistical method for estimating the effective population size in Pacific salmon." J. of Heredity. 83. 309-311 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kaplan,N.L., Hedson,R.R. and Iizuka,M.: "The coalescent process in models with selection, recombination and geographic subdivision." Genetical Research Camb. 57. 83-91 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tachida,H. and Iizuka,M.: "Fixation probability in spatially changing environments." Genetical Research Camb. 58. 243-251 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tobari,Y.N: Japan Scientific Societics Press. Drosophila ananassae - Genetical and Biological Aspects., (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nitasaka,E.and Yamazaki,T.: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosophila melanogaster." Proc.Natl.Acad.Sci.USA. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nitasaka,E.and Yamazaki,T.: "The relation ship between DNA structural variations and activities of P elements in P and Q strains of Drosophila melanogaster." Genetical Research. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ohta,T.: "Theoretical study of near neutrality.II.Effect of subdivided population structure with local extinction and recolonization." Genetics. 130. 917-923 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ohta,T.: "The meaning of natural selection revisited at the molecular level." Trends in Ecology and Evolution. 7. 311-312 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahata,N.,Satta,Y.and Klein,J.: "Polymorphism and balancing selection at major histocompatibility complex loci." Genetics. 130. 925-938 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Morita,T.,Takahata,N.et.al.: "Recent and World-wide Introgression to Mus musculus." Proc.Natl.Acad.Sci.USA. 89. 6851-6855 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Matsubayashi,H.,Tobari,Y.N.etal.: "Cytological mapping of On mutants of Drosophila ananassae." Jpn.J.Genet.67. 259-264 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kaneko,M.,Satta,Y.,Matsuura,E.T.and Chigusa,S.: "Evolution of the mitochondrial ATP ase 6 gene in Drosophila.:Unusually high level of polymorphism in D.melanogaster." Genetical Research. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Harada,K.,Kusakabe,S.and Mukai,T.: "Comparative study of P element activity in two natural populations of Drosophila melanogaster." Jpn.J.Genet.66. 725-737 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Koga,A.,Harada,K.,Kusakabe,S.and Mukai,T.: "Spontaneous mutations affecting glycerol-3-phosphate dehydrogenase enzyme activity in Drosophila melanogaster." Jpn.J.Genet.67. 125-132 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tachida,H.and Iizuka,M.: "Persistence of repeated sequences that evolve by replication slippage." Genetics.131. 471-478 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Maruyama,K.and Tachida,H.: "Genetic variability and geographical structure in partially selfing populations." Jpn.J.Genet.67. 39-51 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tajima,F.: "Statistical method for estimating the standard errors of branch lengths in a phylogenetics tree reconstructed without assuming equal rates of nucleotide substitution among different lineages." Molecular Biology and Evolution. 9. 168-181 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tajima,F.: "Statistical method for estimating the effective population size in Pacific salmon." J.of Heredity. 83. 309-311 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kaplan,N.L.,Hudson,R.R.and Iizuka,M.: "The coalescent process in models with selection,recombination and geographic subdivision." Genetical Research Camb.57. 83-91 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tachida,H.and Iizuka,M.: "Fixation probability in spatially changing environments." Genetical Research Camb.58. 243-251 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahata,N.: "The Proceedings of the 17th Taniguchi International Symposium on Biophsics." Japan Scientific Society Press., (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takahata,N.: "Molecular Paleopulation Biology." Japan Scientific Society Press., (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tobari,Y.N.: "Drosophila ananassaeーGenetical and Biological Aspects" Japan Scientific Societics Press., (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 舘田 英典,向井 輝美: "実験集団遺伝子と進化「講座進化6,分子から見た進化」" 東京大学出版会, (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miyashita,N.: "Linkage disequilibrium in the white locusregion of Drosophila melanogaster." Genetics.

    • Related Report
      1991 Annual Research Report
  • [Publications] Harada,K.: "Comparative study of P element activity in two natural populations of Drosophila melanogaster." Japanese Journal of Genetics. 66. 725-737 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Koga,A.: "A method for detecting effect of beneficial mutations in natural populations of Drosophila melanogaster." Genetical Research. 58. 145-156 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ohta,T.: "Role of diversifying selection and gene conversion in evolution of major histocomp atibility complex loci." Proc.Natl.Acd.Sci.USA.88. 6716-6720 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tachida,H.: "A study on a nealy natural mutation model in finite populations." Genetics. 128. 183-192 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tajima,F.: "Statistical method forestimating the standard erros of branch in a phylogenetic free reconstructuralwithout assuming equal rates of nucleotid substitution among different lineages." Molecular Biology and Evolution. 9. 168-181 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kimura,M.: "New Aspect of the Genetics of Molecular Evolution" Japan Scientific Society/SpringerーVerlag, 322 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Mukai,T.,Harada,Kusakabe and T.Yamazaki: "Estimation of Spontaneous mutation rates at enzyme loci in <Drosophila>___ー <melanogaster>___ー" Proc.Natl.Acad.Sci.USA. 66. 29-32 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tanaka,T.,and T.Yamazaki: "Fitness and its components in <Drosophila>___ー <melanogaster>___ー." Jpn.J.Genet.65. 417-426 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nitasaka,E.and T.Yamazaki: "A novel eye morphology induced by P element in somatic tissue of <Drosophila>___ー <melanogaster.>___ー" Molecular and General Genetics. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nitasaka,E.,and T.Yamazaki: "The relationship between DNA structural variations and activities of P elements in typical P and Q strains of <Drosophila>___ー <melanogaster>___ー." Genet.Res.Camb.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nitasaka,E.,M.M.Green,and T.Yamazaki: "The molecular analysis of brown eye color mutations isolated from geographically discrete populations of <Drosophila>___ー <melanogaster>___ー." Proc.Natl.Acad.Sci.USA. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamazaki,T.: "POPULATION BlOLOGY OF GENES AND MOLECULES(Nucleotide polymorphism and evolution of multigine families in Drosophila.)" ed.by N.Takahata and J.F.Crow(Baifukan), 151-167 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nitasaka,E.,and T.Yamazaki: "NEW ASPECT OF GENETICS IN MOLECULAR EVOLUTION(Genetic variation and regulation of P__ー elements in <Drosophila>___ー <melanogaster>___ー.)" ed.by Kimura,M.and T.Takahata(Japan Sci.Press), 1-14 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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