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HLAの分子医学生物学的研究

Research Project

Project/Area Number 02304037
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionKyushu University

Principal Investigator

笹月 健彦  九州大学, 生体防御医学研究所, 教授 (50014121)

Co-Investigator(Kenkyū-buntansha) 雨宮 浩  国立小児病院, 小児医療研究センター, センター長 (80009563)
辻 公美  東海大学, 医学部, 教授 (30055834)
十字 猛夫  東京大学, 医学部, 教授 (20009997)
吉田 孝人  浜松医科大学, 医学部, 教授 (90041847)
柏木 登  北里大学, 医学部, 教授 (60095502)
片桐 一  旭川医科大学, 教授 (10041823)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥35,200,000 (Direct Cost: ¥35,200,000)
Fiscal Year 1992: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1991: ¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 1990: ¥14,700,000 (Direct Cost: ¥14,700,000)
KeywordsHLA / 遺伝的多型性 / 免疫応答 / 臓器移植 / 疾患感受性 / 多重遺伝子族 / 国際HLAワークショップ / 多型 / 遺伝子 / 蛋白質 / 疾病感受性 / 臓器移殖 / 免疫遺伝 / 分子生物学 / 蛋白化学 / 細胞免疫学 / 自己免疫疾患 / 分子進化
Research Abstract

ヒトの主要組織適合抗原HLAは、高度の多型を示することにより、抗原性および免疫応答性の個体差を支配している。抗原性の個体差は、臓器移植に際して拒絶反応を惹起する。また、免疫応答性の個体差は、感染症ならびにそれに引きつづく感染症関連疾患や自己免疫症患への感受性あるいは抵抗性を支配することにより、疾病の重要な遺伝要因を形成している。本研究では、HLA領域内に存在する多数のHLA遺伝子群の構造解析と遺伝的多型性の解析、蛋白レベルでのHLA分子の多型性解析を行うことにより、HLA分子の発現調節機構、立体構造上の特徴、多型と連鎖不平衡の特徴の解明とその獲得機序の解析を行った。また、HLAの機能を解明するために、免疫応答の個体差とHLAとの関連、抗原ペプチドとHLA分子の結合特性、HLAと抗原ペプチドの複合体を認識するT細胞レセプターの構造およびT細胞の機能的サブセットを、ヒトおよびHLAトランスジェニックマウスを応用して解析した。さらに、多くの疾患を対象として、感受性あるいは抵抗性と最も強い相関を示すHLA対立遺伝子群を同定し、その構造的特徴を明らかにした。また複数のHLA分子間の相互作用による免疫応答性および自己免疫疾患との相関形成機序の存在を明らかにした。一方、臓器移植において、移植片の生着予後と移植ペア間のHLA一致性との関連を遺伝子レベルで明らかにし、生着予後の予見性におけるHLA分子の多型性解析の意義を確認した。本研究班での研究成果は、班員を中心としたメンバーによって企画された国際共同研究「第11回国際HLAワークショップ」において発表され、我国におけるHLA研究の先進性は国際的にきわめて高い評価を受けた。

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (164 results)

All Other

All Publications (164 results)

  • [Publications] Nishimura Y: "Expression of human MHC,HLA-DQW6 genes alter the immune response in C57BL/6" J Immunol. 145. 353-360 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nezu N: "Regulation of HLA class II molecule expressions by IFN-γ:The signal transduction mechanism in glioblastoma cell lines" J Immunol. 145. 3126-3135 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Juji T: "HLA-homozygous donors and transfusion-associated graft-Versus-host disease" N Engl J Med. 322. 1007-1007 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kariyone A: "Functional expression of HLA-C blank antigens on human blood lymphocytes" J Immunol. 145. 3714-3718 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsuki K: "HLA antigens in Japanese patients with Myasthenia Gravis" J Clin Invest. 86. 392-399 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kobata T: "A novel homodimeric molecule involved in human T cell activation" J Immunol. 144. 830-835 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamot J: "Presentation of human minor histocompatibiliyy antigens by HLA-B35 or HLA-B38 molecules" Proc Natl Acad Sci USA. 87. 2583-2587 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sekimata M: "Allodeterminatts and evolution of a novel HLA-B5 CREG antigen,HAL-SNA" J Immunol. 144. 3228-3233 (1990)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kamikawaji N: "HLA-DQ restricted CD4+ T cells specific to streptococcal antigen exist in low responder but not in high responder" J Immunol. 146. 2560-2567 (1991)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujisawa K: "High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectant" Eur J Immunol. 21. 2341-2347 (1991)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hiraiwa M: "T cell can recognize the allospecificites formed by the substitution of amino acid associated with HAL-Bw4/Bw6 epitopes" Hum Immunol. 32. 41-45 (1991)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hoshino S: "Polymerase chain reaction-single strand conformation polymorphism analysis of polymorphisms in DPA1 and DPB1 genes:a simple,economical and..." Hum Immunol. 33. 98-107 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hatae K: "Genetic control of non-responsiveness to hepatitis B Virus Vaccine by an extended HLA haplotype" Eur J Immunol. 22. 1899-1905 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Senju S: "Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene" Immunogenetics. 36. 319-325 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kimura A: "DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA" Tissue Antigens. 40. 5-12 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshida M: "Polymerase chain reaction based analysis of polymorphism in the HLA-B gene" Hum Immunol. 34. 257-266 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Odum N: "Signal transduction by HLA class II molecules in human T cells:induction of LFA-1-dependent and independent adhesion" Hum Immunol. 35. 71-84 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Dong RP: "HLA-A and DPB1 loci confer susceptibility to Graves' disease" Hum Immunol. 35. 165-172 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Harada H: "Sequencing and population analysis of four novel HLA-DPA1 alleles" Hum Immunol. 35. 173-178 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Matsubara K: "A rapid and sensitive method for HLA-DRB1 typing by acridine-ester-labeled DNA probes" Hum Immunol. 35. 132-139 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Inamitsu T: "Different recognition of transgenic HLA-DQw6 molecules by mouse CD4+ and CD8+ T cells" Immunogenetics. 35. 46-50 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ishiguro N: "A rat model of human T lymphocyte virus type I(HTLV-I)infection 1.Humoral antibody response,provirus integration,and HTLV-I-associated...." J Exp Med. 176. 981-989 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nomoto K: "Interference with cyclophosphamide-induced skin allograft tolerance by cyclosporin A" J Immunol. 149. 2668-2674 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hiraiwa M: "Effect of the substitution in the helix and the sheet of HLA class I molecule on allorecognition of T cells specific for HLA B51 and HLA Bw53" Hum Immunol. 33. 82-88 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanabe M: "Structural and functional analysis of monomorhpic determinants recognized by mAb reacting with HLA class Iα3 domin" J Immunol. 148. 1613-1618 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hill AVS: "Molecular analysis of the association of HLA-B53 and resistance to severe malaria" Nature. 360. 434-439 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Uchigata Y: "Complete association with HLA-DR4 and insulin-processing to stimulate proliferation of autologous T cells in the insulin autoimmune..." Lancet. 340. 1467-1467 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Imanishi T: "Distinctive patterns of nucleotide subsitution inferred from the phylogenies of the class I major histocompatibility complex genes" J Mol Evol. 35. 196-204 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fukui Y: "T cell repertoire in a transgenic C57BL/6 mice expressing the HLA-DRA gene on the X chromosome" Immunogenetics. 37. 204-211 (1992)

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kawaguchi G: "Structural analysis of HLA-B40 epitopes" Hum Immunol.

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kato N: "Molecular analysis of novel HLA-A33 subtype associated with HLA-B44" Tissue Antigen.

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kata N: "Conservation of genes encoding HLA-B5,B35 cross reactive group antigens in various races" Hum Immunol.

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sato K: "Evolution of the MHC:isolation of class II β-chain cDNA clones from the amphibian Xenopus Laevis" J Immunol.

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Obata F: "A single universal primer for the T-cell receptor (TCR)variable genes allows enzymatic amplification and direct sequencing of TCR cDNA of ..." Hum Immunol.

    • Related Report
      1992 Final Research Report Summary
  • [Publications] Dong RP: "HLA-A and DPB1 loci confer susceptibility to Graves' disease" Hum Immunol. 35. 165-172 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Matsubara K: "A rapid and sensitive method for HLA-DRB1 typing by acridine-ester-labeled DNA probes" Hum Immunol. 35. 132-139 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nomoto K: "Interference with cyclophosph amide-induced skin allograft tolerance by cyclosporin A" J Immunol. 149. 2668-2674 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Hill AVS: "Molecular analysis of the association of HLA-B53 and resistance to severe malaria" Nature. 360. 434-439 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Uchigata Y: "Strong association of insulinantoimmune syndrome with HLA-DR4" Lancet. 339. 393-394 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Obata F: "A single universal primer for the T-cell receptor(TCR)variable genes allows enzymatic amplification and direct sequencing of TCR cDNA of various T-cell clones" Hum Immunol.

    • Related Report
      1992 Annual Research Report
  • [Publications] Kamikawaji,N.,Fujisawa,K.,Yoshizumi,H.,Fukunaga,M.,Yasunami,M.,Kimura,A.,Nishimura,Y.,Sasazuki,T.: "HLAーDQ restricted CD4^+ T cells specific to streptococcal antigen exist in low responders but not in high responders." Journal of Immunology. 146. 2560-2567 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nagafuchi,S.,Kashiwagi,S.,Okada,K.,Anzai,K.,Nakamura,M.,Nishimura,Y.,Sasazuki,T.,Niho,Y.: "Reversal of nonーresponders and postexposure prophylaxis by intradermal hepatitis B vaccination in Japanese medical personnel." Journal of American Medical Association. 265. 2679-2683 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishimura,Y.,Okubo,R.,Minato,S.,Itoyama,Y.,Goto,I.,Mori,M.,Hirayama,K.,Sasazuki,T.: "A possible association between HLA and HTLVーI associated myelopathy(HAM) in Japanese." Tissue Antigens. 37. 230-231 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fujisawa,K.,Kamikawaji,N.,Yasunami,M.,Kimura,A.,Nishimura,Y.,Sasazuki,T.: "High precursor frequency of human T cells reactive to HLAーDQ molecules expressed on mouse L cell transfectants." European Journal of Immunology. 21. 2341-2347 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishimura,Y.,Kamikawaji,N.,Fujisawa,K.,Yoshizumi,H.,Yasunami,M.,Kimura,A.,Sasazuki,T.: "Genetic control of immune response and disease susceptibility by the HLAーDQ gene.In“The proceedings of the international symposium on Ir gene; from Biology to Medicine"" Research in Immunology. 142. 459-466 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Inamitsu,T.,Nishimura,Y.,Sasazuki,T.: "Different recognition of transgenic HLAーDQw6 molecules by mouse CD4^+ and CD8^+ T cells." Immunogenetics. 35. 46-50 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Dong,R.P.,Kimura,A.,Numano,F.,Nishimura,Y.,Sasazuki,T.: "HLAーlinked susceptibility and resistance to Takayasu arteritis." Heart and Vessels,Supplement 7.

    • Related Report
      1991 Annual Research Report
  • [Publications] Dong,R.P.,Kimura,A.,Sasazuki,T.: "Sequence analysis of three noble DRw14ーDRB1 alleles." Immunogenetics.

    • Related Report
      1991 Annual Research Report
  • [Publications] Dong,R.P.,Kimura,A.,Numano,F.,Yajima,M.,Hashimoto,Y.,Kishi,Y.,Nishimura,Y.,Sasazuki,T.: "HLAーDP antigen and Takayasu arteritis" Tissue Antigens.

    • Related Report
      1991 Annual Research Report
  • [Publications] Hatae,K.,Kimura,A.,Okubo,R.,Watanabe,H.,Erlich,H.,Ueda,K.,Nishimura,Y.,Sasazuki,T.: "GEnetic control of nonーimmune responsiveness to hepatitis B virus vaccine by an extended HLA haplotype." European Journal of Immunology.

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 泰治: "ヒトの免疫応答と疾病感受性の遺伝支配" からだの科学. 12. 149-155 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 泰治: "自己免疫疾患とHLA遺伝子" 細胞工学. 10 Suppl.s161-s170 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 泰治,笹月 健彦: "HLAーDQによる免疫応答の制御" Medical Immunology. 21. 171-177 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 泰治: "HLAの分子生物学と自己免疫疾患" 実験医学. 10. 33-39 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yamamoto,J.,Hiraiwa,M.,Hayashi,H.,Kono,K.,Takiguchi,M.: "Two amino acid substitution at residue 63 and 67 between HLAーB51 and HLAーBw52 form multiple epitopes recognized by allogeneic T cells." Immunogenetics. 33. 286-289 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sekimata,M.,Griem,P.,Rammensee,HーG.,Takiguchi,M.: "Isolation of human minor histocompatibility peptides" Int.Immunol.

    • Related Report
      1991 Annual Research Report
  • [Publications] 滝口 雅文: "MHCとCD8の相互作用" 細胞工学. 10. 933-938 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Konnagi,M.,Harada,S.,Maruyama,I.,Inoko,H.,Igarashi,H.,Kuwashima,G.,Sato,S.,Murita,M.,Kidokoro,M.: "Predominant recognition of human Tーcell leukemia virus typel (HTLVー1) PX gene products by human CD8+ cytotoxic Tーcells directed against HTLVー1 infected cells." International Immunology. 3. 761-768 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Figulroa,F.,Uigin,C.U.,Inoko,H.,Klein,J.: "Primate DRB6 pseudogenes:clue to the evolutionary origin of the HLAーDR2 haplotype." Immunogenetics. 34. 324-337 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 猪子 英俊: "PCR法によるHLAクラスII抗原のDNAタイピング" 代謝免疫. 28. 161-174 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Moriuchi,J.,Ichikawa,Y.,Takaya,M.,Shimizu,H.,Tsuji,K.,Wakisaka,A.,Dawkins,R.L.,Arimori,S.: "Association of the complement allele C4AQ0 with primary Sjogren's syndrome in Japanese patients." Arthritis and Rheumatisms. 34. 224-227 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 脇坂 明美: "インスリン依存性糖尿病とHLA" BIOmedica. 6. 37-41 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 福田 康彦,星野 修司,土肥 雪彦,木村 彰方,笹月 健彦: "1ハプロタイプ適合腎移植例におけるHLAクラスII遺伝子群のDNAタイピング" 移植. 26 suppl.208 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 土肥 雪彦,福田 康彦: "一般実地医家のための移植免疫の知識" 日本医事新報. 3521. 8-13 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Inoue,D.,Sato,K.,Maeda,M.,Inoko,H.,Tsuji,K.,Mori,T.,Imura,H.: "Genetic differences shown by HLA typing among Japanese patients with euthyroid graves' ophthalmopathy, Graves' disease and Hashimoto's thyroiditis: genetic characteristics of euthyroid Graves' ophthalmopathy." Clinical Endocrinology. 34. 57-62 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kuma,K.,Iwabe,N.,Miyata,T.: "Motifs of Immunoglobulinーlike domains:Neurotrophic factor receptors trk and trkβ are members of the immunoglobulin family." Proc. Japan Acad.67. 188-192 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山崎 泰宏,三代川 斉之,片桐 一: "I型糖尿病とHLAクラスII抗原" 臨床医学. 27. 1096-1105 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yanaga,K.,Shimada,M.,Gordon RD.,et al.: "Pancreatic complications following orthotopic liver transplantation." Clin Transplantation.

    • Related Report
      1991 Annual Research Report
  • [Publications] Ogahara,S.,Abe,K.,Naito,S.,Arakawa,K.: "Analysis of HLA class II genes in Japanese with idiopathic membranous glomeruloncphritis(IMG)." Kidney international. 41. 175-182 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小河原 悟,内藤 説也: "PCR(ポリメラ-ゼ連鎖反応)法" 腎と透析. 30. 597-600 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sada,M.,Amemiya,H.,Inoko,H.: "Analysis of enzymatically amplified HLAーDQA using restriction fragment length polymorphism." Transplantation. 23. 464-467 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Watanabe,K.,Yuge,K.,Sato,K.,Sonoda,K.,Masaki,K.,Maruyama,S.,Okubo,M.,Obata,F.,Kashiwagi,N.: "Donor bone marrow cell facilitates induction of tolerance to kidney allografts in dogs treated with fractionated lymphoid irradiation and FK506." Transplantation. 23. 568-572 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kuwata,S.,Tokunaga,K.,Jin,F.,Juji,T.,Sasaki,T.,Honda,Y.: "Analysis of HLAーDRB gene in Narcolepsy." New England Journal of Medicine. 324. 271-272 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Uchigata,Y.,Kuwata,S.,Tokunaga,K.,Eguchi,Y.,TakayamaーHasumi,S.,Miyamoto,M.,Omori,Y.,Juji,T.: "A novel strongly HLAーassociated disease:Insulin autoimmune syndrome." Lancet.

    • Related Report
      1991 Annual Research Report
  • [Publications] 高橋 孝喜,十字 猛夫: "輸血によるGVHD。" 外科診療.

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 泰治,上川路 信博,笹月 健彦: "抗原特異的T細胞増殖反応による免疫抑制遺伝子の解析「生化学実験構座」第12巻分子免疫学II免疫遺伝学・アレルギ-、日本生化学会編" 東京化学同人 東京, 6 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 泰治: "トランスジェニックマウスを用いたMHCの解析「生化学実験講座」第12巻分子免疫学II免疫遺伝学・アレルギ-、日本生化学会編" 東京化学同人 東京, 7 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishimura,Y.,Kamikawaji,N.,Fujisawa,K.,Yoshizumi,H.,Yasunami,M.,Kimura,A.,Sasazuki,T.: "Contribution of the HLAーDQ gene in controling immune response and disease susceptibility.In “The proceedings of the international congress on genetic intervention for diseases with unknown dtiology" in “Molecular Approaches to the Study and Treatment of Human Diseases" eds T.O.Yoshida & J.M.Wilson" Elsevier Science Publisher, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Fukui,Y.,Esaki,Y.,Yasunami,M.,Kimura,K.,Hirokawa,K.,Nishimura,Y.,Sasazuki,T.: "T cell repertoire and selfーtolerance in the transgenic mice with HLAーDRA on X chromosome.in “HLA1991 Vo.II" eds.Tsuji,K.,Aizawa,M.,Sasazuki,T." Oxford University Press,Oxford, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Esaki,Y.,Fukui,Y.,Yasunami,M.,Kimura,A.,Hirokawa,K.,Nishimura,Y.,Sasazuki,T.: "Functional expression of HLAーDQw4 genes in a line of transgenic C57BL/6 mouse.in “HLA 1991 Vol.II" eds.Tsuji,K.,Aizawa,M.,Sasazuki,T." Oxford University press,Oxford, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yoshizumi,H.,Kamikawaji,N.,Okumura,K.,Nishimura,Y.,Sasazuki,T: "Down regulation of immune response by CD8^+ cytotoxic T cells specific to autologous antigen presenting cells.in “HLA 1991 Vol.II" eds.Tsuji,K.,Aizawa,M.,Sasazuki,T." Oxford University Press,Oxford, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kimura,A.,Sasazuki,T.: "Organization and design of the DNA component of the 11th HLA Workshop.in “HLA 1991 Vol.I" eds.Tsuji,K.,Aizawa,M.,Sasazuki,T." Oxford University Press,Oxford, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 猪子 英俊: "PCRーRFLP法によるHLAタイピング 「新生化学実験講座」第12巻分子免疫学II免疫遺伝学・アレルギ-、日本生化学会編" 東京科学同人、東京, 14 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 前田 平生,平田 蘭子: "二次元ゲル等電点電気泳動によるHLA抗原多型性の解析 「新生化学実験講座」第12巻分子免疫学II免疫遺伝学・アレルギ-、日本生化学会編" 東京科学同人、東京, 11 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小幡 文弥: "PCRーSSO法によるHLAタイピング 「新生化学実験講座」第12巻分子免疫学II免疫遺伝学・アレルギ-、日本生化学会編" 東京科学同人、東京, 12 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Todd,J.A.: "The A3 allele of the HLAーDQA1 locus is associated with susceptibility to type 1 diabetes in Japanese." Proceedings of the National Academy of Science,U.S.A.87. 1094-1098 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nishimura,Y.: "Expression of human major histocompatibility complex,HLAーDQw6 genes alters the immuneresponse in C57BL/6 mice." Journal of Immunology. 145. 353-360 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Watanabe,H.: "HLAーBw54ーDR4ーDRw53ーDQw4 haplotype controls nonresponsiveness to hepatitisーB surface antigen via CD8ーpositive suppressor T cells" Tissue Antigens. 36. 69-74 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Begovich A.B.: "HLAーDP β and susceptibility to multiple sclerosis:an analysis of Caucasoid and Japanese patient populations." Human Immunology. 28. 365-372 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ottenhoff,T.H.M.: "HLAーDQ molecules and the control of Mycobacterium Leprae Specific T cell nonresponsiveness in lepromatous leprosy patients." European Journal of Immunology. 20. 2347-2350 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sasazuki,T.: "HLA linked immune suppression genes." Japanese Journal of Human Genetics. 35. 1-13 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Urabe,K.: "Gene conversion in steroid 21ーhydroxylase genes." American Journal of Human Genetics. 46. 1178-1186 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 上川路 信博: "DRではなくDQに拘束されたCD4陽性T細胞によるCD8陽性T細胞の活性化" 福岡医学雑誌. 81. 88-96 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "HLA領域遺伝子群" 肺と心. 37. 277-283 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "HLAクラスII遺伝子群" 蛋白質・核酸・酵素. 35. 3091-3103 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "アロ反応性T細胞が認識するMHC構造およびペプチド" 臨床免疫. 22. 303-310 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "HLAクラスII遺伝子群の発現制御" 日本臨床. 48. 546-550 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "MHC抗原の細胞分布" 日本臨床. 48. 551-553 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "MHC遺伝子の配置" 日本臨床. 48. 554-556 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kamikawaji,N.: "HLAーDQ restricted CD4^+ T cells specific to streptococcal antigen exist in low responders but not in high responders." Journal of Immunology.

    • Related Report
      1990 Annual Research Report
  • [Publications] Muto,M.: "Genetic profiles of psoriasis vulgaris:Family and population study." Proceedings of the 6th JapanーKorea Joint Meeting of Rermatology.

    • Related Report
      1990 Annual Research Report
  • [Publications] Nagafuchi,S.: "Reversal of nonーresponders and postexposure prophylaxis by intradermal hepatitis B vaccinaion in Japanese medical personnel." Journal of American Medical Association.

    • Related Report
      1990 Annual Research Report
  • [Publications] Nishimura,Y.: "A possible association between HLA and HTLVー1 associated myelopathy(HAM) in Japanese" Tissue Antigens.

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "HLAーDQ トランスジェニックマウス" 医学のあゆみ. 154. 482 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "免疫応答および疾患感受性を支配する遺伝要因" 日本体質学会雑誌. 54. 45-47 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 占部 和敬: "21ハイドロキシラ-ゼ欠損症の遺伝子解析" 福岡医学雑誌. 81. 77-87 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 稲光 毅: "MHCとself peptideー免疫応答におけるself peptideの役割" 実験医学. 8. 77-80 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 占部 和敬: "サザンブロット法による診断" 日本臨床. 48. 1795-1800 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 土屋 邦善: "DNA解析による疾患感受性の検出(RAとSLE)" 内科. 66. 697-698 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 土屋 邦善: "分子遺伝学:RA感受性を支配するDRB1遺伝子" 病理と臨床. 8. 1372-1375 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 土屋 邦善: "HLAタイピング" 現代医療. 23. 299-304 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 吉住 秀之: "HLAと免疫抑制遺伝子" 日本臨床. 607. 568-573 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "RFLP解析を用いたHLAクラスII遺伝子のタイピング" Clinical Immunology Newsletter. 10. 60 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 稲光 毅: "トランスジェニックマウスに発現されたHLAーDQ分子の免疫学的機能に関する研究" 福岡医学雑誌. 82. 59-70 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川原田 富朗: "HLAーDQw6遺伝子のマウス・コラ-ゲン誘導性関節炎に対する抑制効果" 福岡医学雑誌. 82. 71-85 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 柴村 和久: "免疫遺伝学からみたスギ花粉症" 科学. 61. 93-97 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 福井 宣規: "自己免疫性内分泌疾患の成因ー遺伝要因としてのHLA" ホルモンと臨床. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "ヒト免疫応答の個体差とその遺伝" アレルギ-の臨床. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 英俊: "日本人IDDMと相関するHLAーDQB遺伝子のDNA塩基配列についての検討" 北海道医学雑誌. 65. 412-418 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Ashida: "Signal Transduction Mechanisms of Ia Induction in B Cells by Interleukin 4 and Immunoglobulin Receptors." Cellular Immunology. 126. 233-238 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 秋山 暢夫: "移植免疫" 透析会誌. 23. 1335-1340 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Obata,F.: "Sequence analysis and oligonucleotide genotyping of HLAーDR“JX6",a DR black haplotype found in the Japanese population" Human Immunol. 27. 269-284 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hiki,Y.: "The role of HLAーDR4 in the long term prognosis of IgA nephropathy" Nephron. 54. 264-265 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Obata,F.: "Sequance analysis and HLAーDR genotyping of a novel HLAーDRw14 allele" Immunogenetics. 32. 313-320 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N,Nezu.: "Regulation of HLA class II molecule expression by IFNーγ:The signal transduction mechanism in glioblastoma cell lines" Journal of Immunology. 145. 3126-3135 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N,Nezu.: "Functional roles of three district HLA class II molecules expressed by a geneーtransfer technique" Transplantation Proceedings. 20. 2345-2351 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takeuchi,F.: "Susceptibility epitope on HLAーDRβ chain for rheumatoid arthritis and the effect of the posibility on the clinical features" Journal of Immunogenetics. 16. 475-483 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamada,H.: "Lack of gene deletion for complement C4A deficiency in Japanese patients with systemic lupus erythematousus." Journal of Rheumatology. 17. 1054-1057 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takeuchi,F.: "Antibody to a specific HLAーDRB1 sequence in Japan patients with rheumatoid arthritis" Artheitis and Rheumatism. 33. 1867-1868 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Matsuno.: "Importance of DQB as an indicator in living related kindney transplant." Transplantation. 49. 208-212 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.Uryu.: "A simple and rapid method for HLAーDRB and DQB typing by digestion of PCRーamplified DNA with allele specific restriction endonucleases." Tissue Antigens. 35. 20-31 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 野村 倍宏: "HLA抗原からみたアジア地域の同種骨髄移植ネットワ-クシステムの可能性" 今日の移植. 3. 374-351 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H,Amamiya.: "A novel rescue drug,15ーdeoxyspergualin" Transplantation. 49. 337-343 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] S,Suzuki.: "Prolongation of graft survival by pretransplant administration of doner spleen cells and 15ーdeoxyspergualin" Transplantation Proceedings. 22. 1624-1625 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] R,Hayashi.: "Synergistic effect of cyclosporine and mizoribine on graft survival in effect of the posibility on the clinical features." Transplantation Proceedings. 22. 1676-1678 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H,Inoko.: "PCRーRFLP method holds great promise for compete HLA class II genotyping" Tissue Antigens. 36. 88-92 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] P.Zhou: "Thymic deletion of Vβ11^+,Vβ5^+ T cells in Hー2E negative HLAーDQβ^+ transgenic mice" Journal of Immunology. 146. 854-859 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] N,Okamoto.: "Orintation of HLAーDNA genes and identifition of a CpG island associated gene adjacent to DNA in human major histocompatibility complex class II region" Human Immunology. 印刷中.

    • Related Report
      1990 Annual Research Report
  • [Publications] Y,Sugiyama.: "Analysis of HLA Antigen in Patients with Diffuse Panbronchiolitis" Am Rev Respir Dis. 141. 1459-62 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K,Matsuki.: "HLA Antigen in Japanese Patients with Myasthenia Gravis" Journal of Clinical Investigation. 86. 392-99 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 前田 平生: "主要組織適合抗原複合体(MHC)欠損症" 小児内科. 20. 720-23 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 村田 敏晃: "透析患者における硝酸イソソルビド(ISDN)テ-プの血中濃度およびテ-プ内残存率" 透析会誌. 23. 1357-1361 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Gojobori,T.: "Statistical method for estimating sequence divergence" Methods in Enzymology. 183. 531-550 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Gojobori,T.: "Molecular clock of viral evolution and the neutral theory" Proceedings of the National Academy of Aciences,USA.87. 10015-10018 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shiroish,T.: "Recombination hotspot specific to female meiosis in the mouse major histocompatibility complex." Immunogenetics. 31. 79-88 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kuma,K.: "Gene families and evolution:Immunolobulin family" Current Opinion in Structural Biology.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kono,T.: "Murine interleukin β chain:Dysregulated gene expression in lymphoma line ELー4 caused by promoter insertion." Proc.Natl.Acad.Sci.USA. 87. 1806-1810 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 石川 哲大: "Allogenic antigen刺激下における単球膜表面のHLAーDR,DQ抗原の変動" 医学のあゆみ. 152. 397-398 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 石川 哲大: "アロ抗原特異的suppressor/killer T細胞誘導に関するHLA抗原の役割" 臨床免疫. 22. 318-327 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Aparicio,J.M.R.: "NonーHLA genetics Factors and insulin dependent diabetes mellitus in the Japanese." Disease Markers. 8. 283-294 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Wakisaka,A: "HLA and IDDM in Japanese" Proceedings of the 6th International Congress of Mucosal Immunology. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 脇坂 明美: "インスリン依存性糖尿病とHLA" Biomedica. 6. 253-257 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yanaga,K.: "A new liver perfusion and preservation system for transplantation research in large animals" J.Invest.Surg.3. 65-75 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 矢永 勝彦: "部分肝移植" 外科治療. 63. 53-58 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sasazuki,T.: "Structural analysis of the genes within the HLA class III region on chromosome 6." Academic press, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "Annual Review免疫1990 HLAーDQと免疫抑制" 中外医学社 東京, 9 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 彰方: "HLA 分子生物学の進歩,14ヒト遺伝子から医学へ(日本分子生物学会編)" 丸善 東京, 17 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岡本 安弘: "慢性関節リウマチの理解のために 5遺伝 「慢性関節リウマチ」水島裕編集」" 南江堂 東京, 6 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "Annual Review免疫1991 MHCトランスジェニックマウス" 中外医学社, 10 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 猪子 英俊: "自己と非自己の識別 岩波講座「分子生物科学」(本庶 祐編)" 岩波書店 東京, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "抗原特異的T細胞増殖反応による免疫応答抑制遺伝子の解析 「生化学実験講座」第12巻分子免疫学II免疫遺伝学・アレルギ-" 東京化学同人 東京, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 西村 泰治: "トランスジェニックマウスを用いたMHCの解析 「生化学実験講座」第12巻分子免疫学" 東京化学同人 東京, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 秋山 暢夫: "腎移植の現況,Annual Review腎臓1990" 中外医学社, 209-214 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 秋山 暢夫: "臓器移植フィジビリティースタディー現況と将来" 東京医学社, (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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