• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The cystic degeneration and carcinogenesis of the kidney

Research Project

Project/Area Number 02304047
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionFaculty of Medicine, University of the Ryukyus

Principal Investigator

OSAWA Akira  University of the Ryukyus, Urology, Professor, 医学部・泌尿器科, 教授 (70045251)

Co-Investigator(Kenkyū-buntansha) HIDAI Hideo  St. Mariana University, Urology, Instructor, 泌尿器科, 兼任講師 (30046007)
ISHIKAWA Isao  Kanazawa Medical University, Nephrology, Professor, 腎臓内科, 教授 (30097414)
KOISO Kenkichi  University of Tsukuba, Urology, Professor, 臨床医学系・泌尿器科, 教授 (20010192)
SAITO Yutaka  Nagasaki University, Urology, Professor, 医学部・泌尿器科, 教授 (70039832)
ASO Yoshio  University of Tokyo, Urology, Professor, 医学部・泌尿器科, 教授 (00009961)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥20,300,000 (Direct Cost: ¥20,300,000)
Fiscal Year 1991: ¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1990: ¥14,200,000 (Direct Cost: ¥14,200,000)
KeywordsRenal cysts / ACDK (Aquired renal diseases of kidney) / Renal cancer / Cytokines / Growth factor / Cyst formation promoting activity / Renal tubes / Oxygentoxicity / 上皮成長因子(EGF) / トランスフォ-ミング増殖因子(TGF) / グルタチオン(GSH) / 上皮膜抗原(EMA) / BSAー11 / インタ-ロイキン1(ILー1) / 糸球体性嚢胞
Research Abstract

1. Epidemiology on cyst and RCC.
Patients exposed to long-term hemodialysis has definite tendency to develop the acquired renal cystic disease of kidney (ACDK) in adults and are predisposed to form of embryonal hyperplasia of bowman's capsular epithelium if they are children. Incidence of renal cell carcinoma (RCC) in dialysis patients is 6.3 fold the expected rates in the general population. We collected 5779 cases of RCC from 385 clinics, out of which 223 cases (3.9%) were associated with renal cysts. On these 223 cases, 32% of them were associated with a simple cyst, 28% with ACDK and 9% with multilocular cyst. The incidence of multiple and/or bilateral tumors was higher in patients on hemodialysis than patients without having hemodialysis treatment. The percentage of low stage tumor was also higher in hemodialysis patients.
2. Pathogeneses of renal cyst and cancer.
Hyperplasia of renal tubular epithelium appeared to be responsible for cyst formation which probably was regulated partia … More lly by several cytokines, such as EGF, TGF-beta, IL-6 and so on. Their activity was estimated by measuring cyst formation promoting activity using MDCK cells. The epithelial hyperplasia and subsequent formation of cyst may induce an increased risk for malignancy. Several supporting evidences were obtained in this study. In experimental drug-induced renal cystic disease, C-myc gene was transiently recognized in renal tubular tissues. Level of glutathione, which is well known as one of deoxidation coenzymes, in both cystic fluid and cyst wall, was significantly low suggesting the possibility that active oxygen toxicity can be induced in the cystic epithelium. Some of the antigenicities on epithelial cells of the cyst wall differed from that on the surface of normal proximal or distal tubular epithelium. In addition, immunohistochemical analysis indicated that the cyst wall of ACDK showed a kind of precancerous predisposition. On the other hand, number of the renal cysts in patients on maintenance hemodialysis was founded to decrease with time after renal transplantation. Lymphocyte-mediated cytotoxicity and cytokine production by PBL were significantly suppressed in some patients on maintenance hemodialysis within 5 years of the therapy initiation as compared to those in normal controls.
From above findings.
Renal failure and its associated immunological alteration, together with formation of renal cysts, are major factors containing responsible mechanisms for higher frequency of development of RCC in hemodialysis patients. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (70 results)

All Other

All Publications (70 results)

  • [Publications] Inamoto,H.: "Incidence and Motality Pattern of Malignancy and Factors Affecting the Risk of Malignancy in Dialysis Patients" Nephron. 59. 611-617 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanda,S.: "The Effect of Transfoming Growth Factor-beta on the Alkaline Phosphatase Activity in Rabbit Renal Cortical Tubular Cell Culturo" Cell Biology International Reports. 14. 877-885 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanda,S.: "Transient Increase in Renal Epidermal Growth Factor Content after Unilateral Nephrectomy in the Mouse" Acta Endocrinologica. 124. 188-193 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 神田 滋: "代償性腎成長のメカニズムー培養尿細管細胞を用いてー" 西日本泌尿器科. 53. 471-476 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石川 勲: "透析患者にみられる腎細胞癌ー1990年アンケ-ト集計結果と過去4回のまとめ" 日本透析療法学会誌. 24. 493-497 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ishikawa,I.,et al: "Comparison of severity of acquired renal cysts between CAPD and hemodialysis" Adv.Perit.Dial.7. 91-95 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ishikawa,I.: "Uremic acquired renal cystic disease.Natural history and complications" Nephron. 58. 257-267 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 日台 英雄: "慢性腎不全患者に合併する嚢胞性疾患" 腎と透析. 28. 417-424 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 日台 英雄: "後天性多嚢胞腎と腎細胞癌" 医学のあゆみ. 153. 403-406 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小磯 謙吉: "注目されている腎疾患:先天性多嚢胞腎" 診断と治療. 79. 1603-1606 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小磯 謙吉: "嚢胞腎基礎的・臨床的研究の進展" 医学のあゆみ. 159(6). 390 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 林 英明: "慢性透析患者の多嚢胞化萎縮腎に合併した腎細胞癌の2例" 西日本泌尿器科.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Higashihara,E.: "Clinical aspects of polycystic kidney disease" J.Urol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Higashihara,E.: "Percutaneous reduction of cyst volume of poly cystic kidney disease:Effects on renal function" J.Urol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kunitomo,R.: "Synthesis of cytochrome C derivative that circulates bound to albumin with prolonged in vivo half life" J.Biol.Chem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue,M.: "Expression of a hybryd Cu/Zn-SOD which has high affinity for heparin-like proteo glycans on vascular endotheial cells" J.Biol.Chem.266. 16409-16414 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Eguchi,J.: "Gene expression and immunohistochemical localization of fibroblast growth factor in renal cell carcinoma" Biochem.Biophys.Res.Commun.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Igawa,T.: "HGF may act as a renotropic factor for renal regeneration after various kidney injuries" Kidney Int.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ishikawa,I.: "Acquired cystic disease:Mechanisms and manifestation" Semin.Nephrol.11. 671-684 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 小磯 謙吉: "嚢胞腎の遺伝子分析" Ann Review腎臓、中外医学社. 57-63 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue,M.: "Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surface" FEBS Lett.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 早川 正道: "透析患者末梢血リンパ球のサイトカイン産生能とLAK細胞活性ー短期と長期透析患者の比較検討" 透析会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue,M.: ""Superoxide and Superoxide Dismutase"" Harwood Publ., 450 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue,M.: ""Liver and Aging"" K.Kitani,eds.Elsevier, 353-360 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue,M.: "Frontias of Mucasal Immunology" Y.Tsuchiya,ed.Excerpta Medica, 527-530 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 井上 正康: "活性酸素と病態" 学会出版センタ-, 1-800 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inamoto, H.: "Incidence and Motality Pattern of Malignancy and Factors Affecting the Risk of Malignancy in Dialysis Patients" Nephron. 59. 611-617 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanda, S.: "The Effects of Transfoming Growth Factor-bata on Alkaline Phosphatase Activity in Rabbit Renal Cortical Tubular Cell Culture" Cell Biology International Reports. 14. 877-885 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanda, S.: "Transient Increase in Renal Epidermal Growth Factor Content after Unilateral Nephrectomy in the Mouse" Acta Endocrinologica. 124. 188-193 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ishikawa, I. et al.: "Comparison of severity of acquired renal cysts between CAPD and hemodialysis" Adv. Perit. Dial.7. 91-95 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ishikawa, I.: "Uremic acquired renal cystic disease. Natural history and complications" Nephron. 58. 257-267 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Higashihara, E.: "Clinical aspects of polycystic kidney disease" J. Urol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Higashihara, E.: "Percutaneous reduction of cyst volume of poly cystic kidney disease : Effects on renal function" J. Urol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kunitomo, R.: "Synthesis of cytochrome C derivative that circulates bound to albumin with prolonged in vivo half life" J. Biol. Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue, M.: "Expression of a hybryd Cu/Zu-SOD which has high affinity for heparin-like proteo glycans on vascular endothelial cells" J. Biol. Chem.266. 16409-16414 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Eguchi, J.: "Gene expression and immunohistochemical localization of fibroblast growth factor in renal cell carcinoma" Biochem. Biophys. Res. Commun.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Igawa, T.: "HGF may act as a renotropic factor for renal regeneration after various kidney injuries" Kidney Int.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ishikawa, I.: "Acquired cystic disease : Mechanisms and manifestation" Semin. Nephrol.11. 671-684 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue, M.: "Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surface" FEBS Lett.269. 89-92 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue, M.: Harwood Publ.Superoxide and Superoxide Dismutase, 450 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue, M.: Elservier. Liver and Aging, 353-360 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inoue, M.: Excepta Medica. Frontias of Mucasal Immunology, 527-530 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Inamoto,H.: "Incidence and Motality Pattern of Malignancy and Factors Affecting the Risk of Malignancy in Dialysis Patients" Nephron. 59. 611-617 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kanda,S.: "The Effect of Transfoming Growth Factorーbeta on the Alkaline Phosphatase Activity in Rabbit Renal Cortical Tubular Cell Culture" Cell Bilogy International Reports. 14. 877-885 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kanda,S.: "Transient Increase in Renal Epidermal growth Factor Content after Unilateral Nephrectomy in the Mouse" Acta Endocrinologica. 124. 188-193 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 神田 滋: "代償性腎成長のメカニズムー培養尿細管細胞を用いてー" 西日本泌尿器科. 53. 471-476 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 石川 勲: "透析患者にみられる腎細胞癌ー1990年アンケ-ト集計結果と過去4回のまとめ" 日本透析療法学会誌. 24. 493-497 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ishikawa,I.,et al: "Comparison of severity of acquired renal cysts between CAPD and hemodialysis" Adv.Perit.Dial.7. 91-95 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ishikawa,I.: "Uremic acquired renal cystic disease.Natural history and complications" Nephron. 58. 257-267 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 日台 英雄: "慢性腎不全患者に合併する嚢胞性疾患" 腎と透析. 28. 417-424 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 日台 英雄: "俊天性多嚢胞腎と腎細胞癌" 医学のあゆみ. 153. 403-406 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小磯 謙吉: "注目されている腎疾患:先天性多嚢胞腎" 診断と治療. 79. 1603-1606 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小磯 謙吉: "嚢胞腎 基礎的・臨床的研究の進展" 医学のあゆみ. 159(6). 390 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 林 英明: "慢性透析患者の多嚢胞化萎縮腎に合併した腎細胞癌の2例" 西日本泌尿科.

    • Related Report
      1991 Annual Research Report
  • [Publications] Higashihara,E.: "Clinical aspects of polycystic kidney disease" J.Urol.

    • Related Report
      1991 Annual Research Report
  • [Publications] Higashihara,E.: "Percutaneous reduction of cyst volume of poly cystic kidney disease:Effects on renal function" J.Urol.

    • Related Report
      1991 Annual Research Report
  • [Publications] Kunitomo,R.: "Synthesis of cytochrome C derivative that circulates bound to albumin with prolonged in vivo half life" J.Biol.Chem.

    • Related Report
      1991 Annual Research Report
  • [Publications] Inoue,M.: "Expression of a hybryd Cu/ZnーSOD which has high affinity for heparinーlike proteo glycans on vascular endothelial cells" J.Biol.Chem.266. 16409-16414 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Inoue,M.: ""Superoxide and Superoxide Dismutase"" Harwood Publ., 450 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kanda,S.: "Effect of lymphokines on the grwoth of cultured rabbit renal cortical tubular cells." Jpn.J.Nephrol.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kanda,S.: "Transient increase in renal epidermal growth factor content after unilateral nephrectomy in the mouse." Acta Endocrinologica.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小磯 謙吉: "嚢胞腎の遺伝子分析。" Annual Review「腎臓」. 57-63 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] "Clinicopathological study of kidneys from patients on chronic dialysis." Kidney International.37. 1333-1340 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ishikawa I.: "Cystic transformation in native kidneys in renal allograft recipients with longーstanding good function."

    • Related Report
      1990 Annual Research Report
  • [Publications] 石川 勲: "透析患者にみられる腎細胞癌ー1990年アンケ-ト集計結果と過去4回のまとめー" 透析会誌.

    • Related Report
      1990 Annual Research Report
  • [Publications] Inoue M.: "Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surfacce." FEBS Lett.269. 89-92 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 日台 英雄: "慢性腎不全に合併する嚢胞性疾患。" 腎と透析. 28. 417-424 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 日台 英雄: "後天性多嚢胞腎と腎細胞癌。" 医学のあゆみ. 153. 403-406 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ishikawa I.: "Acquired renal cystic disease.The Cystic Kidney." Gardner KDJr,Bernstein J,eds.Kluwer Academic Publishers,Dordrecht., 351-377 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ishikawa I.: "Comparison of cyst characteristics in acquired and inherited renal cystic disease.Advances in the Pathogenesis of Polycystic Kidney Disease." Carone FA,Dobbie JW eds,Baxter Healthcare Corporation,Chicago,Illinois., 85-90 (1990)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi