| Project/Area Number |
02304055
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
医学一般
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MARUMO Fumiaki Tokyo Med. Dent. Univ. Dept. Med. Professor, 医学部, 教授 (00050443)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO T Jichi Med. School Dept.Med. Professor, 教授 (10048994)
KUROKAWA K Univ. of Tokyo Dept. Med. Professor, 医学部, 教授 (30167390)
ORITA Y University Medical School Professor, 医学部, 助教授 (70028398)
ENDO H Univ. of Tokyo Dept. Med. Associate Professor, 医学部, 助教授 (20101115)
IMAI M Jichi Med. School Dept. Pnarmacol. Professor, 教授 (40049010)
乾 賢一 東京医科歯科大学, 薬剤部, 教授 (70034030)
猿田 享男 慶應義塾大学, 内科学, 教授 (70051571)
田島 陽太郎 秋田大学, 第二生化学, 教授 (30049796)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1992: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | autoregulation / renal function / hormones / body fluid / mesangium cell / tubular cell / signal transduction / water channel / エンドセリン / レセプター / バゾプレッシン / オ-トクリン / カルシウムイオン / 腎尿細管 / cAMP / 体液調節 / 腎 / 内分泌 / 高血圧 / 利尿 |
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| Research Abstract |
To maintain body fluid homeostasis, autoregulatory mechanism including osmolarity, electrolytes, acid-base balance, nutritents, water etc, plays important roles in human body. To elucidate autoregulatory mechanism, especially kidney function and hormone actions, the present research project team was organized. The results revealed the primary structure of a novel vasopressin-sensitive water channel from rat renal collecting duct, interaction of thiazide or amiloride with PTH in stimulating Ca2+ absorption in rabbit connecting tubulus, localization of hormone receptors and their signal transductions along rat nephron, angiotensin-mediated signal transduction in rat glomerular mesangial cells, mesangial function and chloride ions, vasopressin-induced signal transduction of rat medullary collecting duct, NO-induced hypotension and natriuresis/diuresis in rat, structure/function relationship of aldosteron receptor, regulation of proton cotranspoter for drug transport in proximal tubulus, and endothelins-induced signal transduction in vascular endothelial and smooth muscle cells.
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