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Brain Control of the Reproductive System

Research Project

Project/Area Number 02305004
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionNagoya University

Principal Investigator

YOKOYAMA Akira  Nagoya University, Professor emeritus, 名誉教授 (50023388)

Co-Investigator(Kenkyū-buntansha) TAYA Kazuyoshi  Tokyo University of Agriculture and Technology, Associate Professor, 農学部, 助教授 (60092491)
MORI Yuji  University of Tokyo, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (40157871)
MAEDA Kei-ichiro  Nagoya University, School of Agricultural Sciences, Associate Professor, 農学部, 講師 (30181580)
HIGUCHI Takashi  Fukui Medical School, Associate Professor, 医学部, 助教授 (70106326)
SAKUMA Yasuo  Hirosaki University, School of Medicine, Professor, 医学部, 教授 (70094307)
兼松 重任  岩手大学, 農学部, 教授 (50003744)
西塚 雅子  順天堂大学, 医学部, 講師 (20133332)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥10,600,000 (Direct Cost: ¥10,600,000)
Fiscal Year 1991: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1990: ¥6,500,000 (Direct Cost: ¥6,500,000)
KeywordsBrain / Reproduction / Neuroendocrinology / Central Nervous System / Environment / Physiology / Morphology
Research Abstract

The purpose of the present research group is to elucidate the location of the pulse generator, which is thought to regulate the pulsatile release of luteinizing hormone (LH) through the pulsatile LH releasing homone (LHRH) release, in the hypothalamus and to make clear the regulatory mechanism of the pulse generator. That oxytocin is released in a pulsatile manner in spite of the continous stimulus to the teat by pups has been well established. Therefore, a search for the location of the LHRH pulse generator is also one of the purposes of this research group.
The presence of the LH pulse generator in the medial basal hypothalamus (MBH) in rats and shiba goats has been demonstrated by the following experiments : 1) Complete deafferentation of the hypothalamus in the rat ; 2) Transplantation of the fetal median eminence (EM) into the adult female rat in which the pulsatile LH secretion was blocked by electrolytic lesions made in the anterior part of the arculate nucleus in rats ; 3) In vi … More tro intra-arterial perfusion of the rat's hypothalamus ; 4) Multiple unit activities (MUA) recording from the arcuate nucleus in shiba goats. An attempt was made to record the single unit activity from the LHRH cell projecting its axon to the ME.
However, the activity was recorded only from a small number of cells and we can not tell whether the LHRH cells themselves generates the pulsatility. Burst discharges of OT cells in the supra optic and paraventricular nuclei were recorded intermittently in the rat suckled continously by pups.
We found several neurones fired synchronously with OT cells in the dorsomedial hypothalamic nucleus. Although these neurones send axons to the supra optic nucleus, no projection of these cells to the posterior lobe of the pituitary is found. Therefore, the possibility exists that these cells transform the continuous impulse emanating from the teat to the intermittent information causing the pulsatile secretion of OT. Relationship between these cells and the LHRH pulse generator is remained unsolved. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Ohkura S.,Tsukamura,H.and Meada,K.-I.: "Effect of various types of hypothalamic deafferentation on luteinizing hormone pulses in ovariectomized rats." J.Neuroendocrinol.3(5). 503-508 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Cagampang,F.R.A.,and Maeda,K.-I.: "Effects of intracerebroventricular administration of opiate receptor antagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol-treated rats." Life Sci.49. 1823-1828 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohkura,S.,Tsukamura,H.,and Maeda,K.-I.: "Effects of transplants of fetal mediobasal hypothalamus on luteinizing hormore pulses impaired by hypothalamic deafferentation in adult ovariectomized rats." Neuroendocrinology. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Higuchi,T.,Honda,K.,Takano,S.,and Negoro,H.: "Estrogen fails to reduce tuberoinfundibular dopaminergic neuronal activity and to cause a prolactin surge in lactating,ovariectomized rats." Neuroendocrinology. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mori,Y.,Nishihara,M.,Tanaka,T.,Shimuzu,T.,Yamaguchi,M.,Takeuchi,Y.,Hoshino,K.: "Chronic recording of elecrtophysiological manifestation of the hypothalamic gonadotropin-releasing hormone pulse generator activity in the goat." Neuroendocrinology. 53. 392-395 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tanaka,T.,Mori,Y.and Hoshino,k.: "Hypothalmaic GnRH pulse generator activity during the estradiol-induced LH surge in ovariecrtomized goats." Neuroendocrinology. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yokoyama,A.: "Brain Control of the Reproductive System" Japan Scientific Press,Tokyo, 194 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohkura, S., Tsukamura, H. and Maeda, K. -I.: "Effect of various types of hypothalamic deafferentation on luteinizing hormone pulses in ovariectomized rats." J. Neuroendocrinol. 3. 503-508 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Cagampang, F. R. A. and Maeda, K. -I.: "Effects of intracerebroventricular administration of opiate receptor angagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol-treated rats." Life Sci.49. 1823-1828 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohkura, S., Tsukamura, H. and Maeda, K. -I.: "Effects of transplants of fetal mediobasal hypothalamus on luteinizing hormone pulses impaired by hypothalamic deafferentation in adult ovariectomized rats." Neuroendocrinology. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Higuchi, T., Honda, K., Takano, S. and Negoro, H.: "Estrogen fails to reduce tuberoinfundibular dopaminergic neuronal activity and to cause a prolactin surge in lactating, ovariectomized rats." Neuroendocrinology. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mori, Y., Nishihara, M., Tanaka, T., Shimuzu, T., Yamaguchi, M., Takeuchi, Y., Hoshino, K.: "Chronic recording of electrophysiological manifestation of the hypothalamic gonadotropin-releasing hormone pulse generator activity in the goat." Neuroendocrinology. 53. 392-395 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tanaka, T., Mori, Y. and Hoshino, K.: "Hypothalamic GnRH pulse generator activity during the estradiol-induced LH surge in ovariectomized goats." Neuroendocrinology. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yokoyama, A.: Japan Scientific Press. Brain Control of the Reproductive System., (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohkura S.: "Effect of various types of hypothalamic deafferentation on luteinizing hormone pulses in ovariectomized rats." J.Neuroendocrinol.3(5). 503-508 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Cagampang,F.R.A.: "Effects of intracerebroventricular administration of opiate receptor antagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol‐treated rats." Life Sci.49. 1823-1828 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ohkura,S.: "Effects of transplants of fetal mediobasal hypothalamus on luteinizing hormone pulses impaired by hypothalamic deafferentation in adult ovariectomized rats." Neuroendocrinology. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Higuchi,T.: "Estrogen fails to reduce tuberoinfundibular dopaminergic neuronal activity and to cause a prolactin surge in lactating,ovariectomized rats." Neuroendocrinology. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Mori,Y.: "Chronic recording of electrophysiological manifestation of the hypothalamic gonadotropin‐releasing hormone pulse generator activity in the goat." Neuroendocrinology. 53. 392-395 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tanaka,T.: "Hypothalmaic GnRH pulse generator activity during the estradiol‐induced LH surge in ovariecrtomized goats." Neuroendocrinology. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yokoyama,A.: "Brain Control of the Reproductive System" Japan Scientific Press,Tokyo, 194 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tsukamura,H.,Maeda,K.ーI.,Ohkura,S.& Yokoyama,A.: "Effect of hypothalamic deafferentation on the pulsatile LH secretion in overiectomized lactating rats." J.Neuroendo.2. 59-63 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Cagampang,F.R.A.,Maeda,K.ーI.,Yokoyama,A.& Ota,K.: "Effect of food deprivation on the pulsatile LH release in the cycling and ovariectomized female rat." Horm.meta.Res.22. 269-272 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Maeda,K.ーI.,Tsukamura,H.,Ohkura,S.,Kanaizuka,T.& Suzuki,J.: "Suppression of ovarian activities during the breeding season in suckling Japanese monkeys(<Macaca fuscata>___ー)." J.Reprod.Fert.92. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ohkura,S.,Tsukamura,H.& Maeda,K.ーI.: "Effect of carious types of hypothalamic deafferentation on luteinizing hormone pulses in ovariectomized rats." J.Neuroendocr.3. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Mori,Y.et al.: "Chronic recording of electrophysiological manifestation of the hypothalamic gonadotropinーreleasing hormone(GnRH)pulse generator activity in the goat." Neuroendocrinology.

    • Related Report
      1990 Annual Research Report
  • [Publications] 前多 敬一郎・森 裕司: "ホルモンの生物科学9,ホルモンと生殖3" 学会出版センタ-, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森 裕司・前多 敬一郎: "時間生物学ハンドブック" 朝倉書店, (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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