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Identification, classification, and information processing in monkey hippocampal neurons in response to loci, objects, and events.

Research Project

Project/Area Number 02404023
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

ONO Taketoshi  Toyama Med. & Pharmaceu. Univ., Fac. Med., Professor, 医学部, 教授 (50019577)

Co-Investigator(Kenkyū-buntansha) MURAMOTO Ken-ichiro  Kanazawa Univ., Fac. Technol., Associate professor, 工学部・電気情報工学科, 助教授 (70042835)
TAMURA Ryoi  Toyama Med. & Pharmaceu. Univ. Fac. Med., Assistant professor, 医学部, 助手 (60227296)
NISHIJO Hisao  Toyama Med. & Pharmaceu. Univ. Fac. Med., Assistant professor, 医学部, 助手 (00189284)
FUKUDA Masaji  Toyama Med. & Pharmaceu. Univ. Fac. Med., Associate professor, 医学部, 助教授 (60126547)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1991: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsMonkey / Hippocampus / Single neuron activity / Memory / Place / Brain ischemia / Ischemic neuronal death / CA1 pyramidal cell / 虚血性壊死
Research Abstract

In this project, hippocampal neuronal activity of awake monkey during discrimination of loci, objects, and events (Study 1), and effects of ischemic neuronal death confined to the monkey hippocarnpus on memory (Study 2) were investigated. In Study 1, a total of 2169 neurons were recorded from the hippocampal formation and surrounding parahippocampal gyrus of awake monkeys while the monkey discriminated various familiar rewarding and aversive objects as well as unfamiliar objects (paradigm 1 ; n=1911), and while the monkey actively controlled the cab to change its location within a 2.5x2.5 m region (paradigm 2 ; n=258). In paradigm 1, visually responsive neurons (n=160) were categorized into the following, based on their responsiveness to biological significance of the objects ; rewarding-object-dominant, aversive-object-dominant, and unfamiliar-object-dominant neurons. In paradigm 2, activity of 165 (64.0%) changed in response to direction related stimuli, or location of the cab contai … More ning the subject, or presentation of objects (food or nonfood). Of 165 responding neurons, 41 responded to a particular stimulus presented from a specific direction (direction-related). Responses of these neurons could be described in terms of egocentric or allocentric coordinates, or combinations of these coordinates. Increase or decrease of spontaneous activity of 79 neurons depended on the animal's specific location within the 2.5x2.5 m field (place-related). The 119 neurons responded in one or more phase (s) of a task that involved cue signals, moving by holding the bar, or reward presentation upon opening of a shutter (task-related). Some of these neurons showed specific combinations of directional, placerelated, and task-related responses.
In Study 2, the monkey subjected to 10-15 min occlusion of 8 (bilateral common carotid, intemal and extemal carotid, and vertebral) major arteries suffered ischemic cell changes restricted to the CA1 subfield of the hippocampus. These monkeys with ischemic insult indicated significant memory disturbance in a delayed non- matching to sample test, while no deficits in motor-skill nor simple visual discrimination task were evident. The intravenous infusion of a calcium blocker (NC-1100) significantly ameliorated ischemic cell changes in the monkey hippocampus. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] Ono,T.: "The hippocampus and space:Are there "Place neurons" in the monkey hippocampus?" Hippocampus. 1. 253-257 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tamura,R.: "Role of monkey hippocampus in recognition of food and nonfood." Brain Res.Bull.27. 457-461 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tamura,R.: "Spatial responsiveness of monkey hippocampal neurons to various visual and auditory stimuli." Hippocampus.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tamura,R.: "Monkey hippocampal neuron resonses to complex sensory stimulation during object discrimination." Hippocampus.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tabuchi,E.: "Hippocampal neuronal damage after transient forebrain ischemia in monkey." Brain Res.Bull.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo,H.: "Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus." Brain Res.Bull.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo,H.: "Neuronal involvement in food recognition." Asia Pacific J.Clin.Nutrition.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo,H.: "Amygdalar and hippocampal neuron responses related to recognition and memory in monkey." Prog.Brain Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura,K.: "Paraventricular neuron chemo-sensitivity and activity related to blood pressure control in emotional behavior." J.Neurophysiol.67. 255-264 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono-T.: "Catecholamine and acetylcholine sensitivity of rat lateral hypothalamic neurons related to learning." J.Neurophysiol.,.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Muramoto,K.: "Rat amygdalar neuron responses during auditory discrimination." Neurosci.,.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono,T.: "Neural mechanisms of recognition and memory in the limbic system.In:Brain Mechanisms of Perception and Memory,T.Ono,L.R.Squire,M.E.Raichle,D.Perrett and M.Fukuda(eds.)" Oxford Univ.Press,New York,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono,T.: "Neurophysiological basis of the Kluver-Bucy syndrome:Responses of monkey amygdaloid neurons to biologically significant objects.In:The Amygdala:Neurobiological Aspects of Emotion,Memory,and Mental Dysfunction,J.Aggleton(ed.)" John Wiley & Sons,New York, 167-190 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo,H.: "Monkey amygdalar and hippocampal responses to food and non-food.In:Progress in Obesity Research,Y.Oomura,S.Tarui,S.Inoue and T.Shimazu(eds.)." John Libbey,London, 53-57 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono, T.: "Place recognition responses of neurons in monkey hippocampus." Neurosci. Lett.121. 194-198 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono, T.: "The hippocampus and space : Are there "Place neurons" in the monkey hippocampus?" Hippocampus. 1. 253-257 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tamura, R.: "Role of monkey hippocampus in recognition of food and nonfood." Brain Res. Bull.27. 457-461 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakamura, K.: "Paraventricular neuron chemo-sensitivity and activity related to blood pressure control in emotional behavior." J. Neurophysiol.67. 255-264 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Muramoto, K.: "Rat amygdalar neuron responses during auditory discrimination." Neurosci.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo, H.: "Amygdalar and hippocampal neuron responses related to recognition and memory in monkey." Prog. Brain Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo, H.: "Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus." Brain Res. Bull.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishijo, H.: "Food memory : Neuronal involvement in food recognition." Asia Pacific J. Clin. Nutrition.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono, T.: "Catecholamine and acetylcholine sensitivity of rat lateral hypothalamic neurons related to learning." J. Neurophysiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tamura, R.: "Monkey hippocampal neuron responses to complex sensory stimulation during object discrimination." Hippocampus.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tamura, R.: "Spatial responsiveness of monkey hippocampal neurons to various visual and auditory stimuli." Hippocampus.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tabuchi, E.: "Hippocampal neuronal damage after transient forebrain ischemia in monkey" Brain Res. Bull.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ono,T.: "The hippocampus and space:Are there “Place neurons" in the monkey hippocampus?" Hippocampus. 1. 253-257 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tamura,R.: "Role of monkey hippocampus in recognition of food and nonfood." Brain Res.Bull.27. 457-461 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tamura,R.: "Spatial responsiveness of monkey hippocampal neurons to various visual and auditory stimuli." Hippocampus.

    • Related Report
      1991 Annual Research Report
  • [Publications] Tamura,R.: "Monkey hippocampal.neuron resonses to complex sensory stimulation during object discrimination." Hippocampus.

    • Related Report
      1991 Annual Research Report
  • [Publications] Tabuchi,E.: "Hippocampal neuronal damage after transient forebrain ischemia in monkey." Brain Res.Bull.

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishijo,H.: "Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus." Brain Res.Bull.

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishijo,H.: "Neuronal involvement in food recognition." Asia Pacific J.Clin Nutrition.

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishijo,H.: "Amygdalar and hippocampal neuron responses related to recongnition and memory in monkey." Prog.Brain Res.

    • Related Report
      1991 Annual Research Report
  • [Publications] Ono,T.: "Neural mechanisms of recognition and memory in the limbic system.In:Brain Mechanisms of Perception and Memory,T.Ono,L.R.Squire,M.E.Raichle,D.Perrett and M.Fukuda(eds.)" Oxford Univ.Press,New York,

    • Related Report
      1991 Annual Research Report
  • [Publications] Ono,T.: "Neurophysiological basis of the KluverーBucy syndrome:Responses of monkey amygdaloid neurons to biologically significant objects.In:The Amygdala:Neurobiological Aspects of Emotion,Memory,and Mental Dysfunction,J.Aggleton(ed.)" John Wiley & Sons,New York, (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishijo,H.: "Monkey amygdalar and hippocampal responses to food and nonーfood.In:Progress in Obesity Research,Y.Oomura,S.Tarui,S.Inoue and T.Shimazu(eds.)" John Libbey,London, 167-190 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Taketoshi Ono: "Place detection neurons in the monkey hippocampus." Neuroscience Letters. 121. 194-198 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ryoi Tamura: "Role of monkey hippocampus in recognition of food and nonfood." Brain Research Bulletin.

    • Related Report
      1990 Annual Research Report
  • [Publications] Taketoshi Ono: "Neurophysiological basis of the Klu^^‥verーBucy syndrome:responses of monkey amygdaloid neurons to biological significant objects.In:The Amygdala" edited by J.Aggleton,John Wiley & Sons,

    • Related Report
      1990 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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