• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Correlations between Lefestyles and Mental- or Physical Health Status

Research Project

Project/Area Number 02404034
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Kanehisa  Osaka Univ. Sch. Med.,Dept.Hyg.Prev.Med., Profeassor, 医学部環境医学教室, 教授 (20143414)

Co-Investigator(Kenkyū-buntansha) EZOE Satoko  Osaka Univ. Sch.Med.,Dept.Hyg.Prev.Med., Assist.Prof., 医学部環境医学教室, 助手 (40232954)
TAKEUCHI Toru  Osaka Univ. Sch. Med.,Dept.Hyg.Prev.Med., Assist.Prof., 医学部環境医学教室, 助手 (00188161)
MARUYAMA.SOICHIRO  Osaka Univ. Sch. Med.,Dept.Hyg.Prev.Med., Assist.Prof., 医学部環境医学教室, 助手 (70219567)
SHIRAKAWA Taro  Osaka Univ. Sch. Med.,Dept.Hyg.Prev.Med., Assist.Prof., 医学部環境医学教室, 助手 (40196613)
TAKESHITA Tatsuya  Osaka Univ. Sch. Med.,Dept.Hyg.Prev.Med., Assoc.Prof., 医学部環境医学教室, 助教授 (20150310)
日下 幸則  大阪大学, 医学部, 講師 (70135680)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1991: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordslifestyle / QOL / health status / chromosome aberration / sister chromatid exchange / aldehyde dehydrogenase / allergy / natural killer cell activity / ライフスタイル / 性格 / 染色体変異 / アルデヒド脱水素酵素 / Natural Killer活性 / 健康維持要因 / ストレス量 / エゴグラム / 精神的健康 / 姉妹染色分体交換(SCE) / IgE / リンパ球培養
Research Abstract

1. In Japanese workers, lifestyles such as smoking. drinking, self-reported stress, physical exercise, mental health status including character and quality of life, and physical health status were comprehensively measured using questionnaires and physical examination data.
2. In the same subjects, frequencies of sister-chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes were measured. Those who have good lifestyles had lower frequencies of SCE and lower enhancement ratios of CA frequencies by ara-C, compared to those with poor lifestyles. Genotypes of low Km ALDH2 were determined by the PCR method. Habitual drinkers who lack ALDH2 had significantly higher SCE frequency than non-habitual drinkers who lack ALDH2 or those who possess ALDH2 activity. Generally, alcohol-drinking bahaviors were strongly regulated by the ALDH2 activity.
3. Natural killer (NK) activities were significantly higher in those with good lifestyles than those with poor lifestyles. Proportions of subsets of lymphocytes were also correlated with good lifestyles.
4. Higher total IgE levels were significantly correlated with lifestyles, especially with smoking, and alcohol consumption.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] Higihara,A.et al.: "Personal health practices and attitudes toward nonsmokers′ legal rights in Japan" Soc.Sci.Med.33. 717-721 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa,T.et al.: "Lifestyle effect on total IgE-Lifestyles have a cumulative impact on controlling total IgE levels" Allergy. 46. 561-569 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kusaka,Y.et al.: "Healthy lifestyles are associated with higher natural killer cell activity" Preventive Medicine. 21. 602-615 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa,T.et al.: "Combined effect of Smoking habits and occupational exposure to hard metal on total IgE antibodies" Chest. 101. 1569-1576 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takeshita,T.et al.: "Phenotypic clifferences in low km aldehyde dehydrogenase.in Japanese.workers" Lancet. 341. 837-838 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morimoto,K.et al.: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity" Int.Arch.Occup.Environ.Health.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 森本 兼曩: "ライフスタイルと健康" 医学書院, 322 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morimoto,K.: "Life-Style and genetic factors that determine the susceptibility to production of chromosome damage." Springer-Verlag,Berlin ed,by Obe,G.and Natarajan,A.T.:Chromosome aberrations.Basic and Applied aspects, 287-301 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa, T., Morimoto, K. et al.: "Hard metal asthma:cross-immunological and resperatory reactivity between cobalt and nickel?" Thorax. 45. 67-271 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Iijima, K,. Morimoto, K.: "Quantitative analyses of the induction of chromosome aberrations and sister chromatid exchanges in human lymphocytes exposed to gamma-rays and Mitomycin-C in combination." Mutation Res. 263. 263-268 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hagihara, A., Morimoto, K.: "Personal health practices and attitudes toward nonsmokers legal rights in japan." Soc. Sci. Med.33. 717-721 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa, T., Morimoto, K.: "Lifestyle effect on total IgE-Lifestyles have a cumulative impact on controlling total IgE levels." Allergy. 46. 561-569 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa, T., Kusaka, Y., and Morimoto, K.: "Specific IgE antibodies to nickel in workers with known reactivity to cobalt." Clinical and Experimental Allergy. 22. 213-218 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kusaka, Y., Kondou, H., and Morimoto, K.: "Healthy lifestyles are associated with higher natural killer cell activity." Preventive Medicine. 21. 602-615 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa, T., Kusaka, Y., and Morimoto, K.: "Combined effect of smoking habits and occupational exposure to hard metal on total IgE antibodies." Chest. 101. 1569-1576 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hagihara, A., Kusaka, Y., Morimoto, K., Tamura, T. and Matsuura, Y.: "Health risk appraisal (HRA) and its educational effects on bank employees." Industrial Health. 30. 61-64 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sandford, A.J., Shirakawa, T., et al.: "Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q." Lancet. 341. 332-334 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takeshita, T., Morimoto, K., Mao, X., Hashimoto, T. and Furuyama, J.: "Phenotypic differences in low Km aldehyde dehydrogenase in Japanese workers." Lancet. 341. 837-838 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morimoto, K., Takeshita, T., Takeuchi, T., Maruyama, S., Ezoe, S., Mure, K. and Inore, C.: "Chromosome alterations in peripheral lymphocytes as indices of lifestyle and genotoxicity." Int. Arch. Occup. Environ. Health.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ezoe, S., Morimoto, K.: "Behavioral lifestyle and mental health status of Japanese factory workers." Preventive Medicine.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takeuchi, T. and Morimoto, K.: "Increased formation of 8-hydroxydeoxyguanosine, an oxidative DNA damage, in lymphoblasts from Fanconi's anemia patients due to possible catalase deficiency." Carcinogenesis 14.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morimoto, K.: Springer-Verlag, Berlin. Life-style and genetic factors that determine the susceptibility to production of chromosome damage. in ed. by Obe, G., Natarajan, A. T.: Chromosomal aberrations. Basic and applied aspects., 287-301 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morimoto, K.: American Conference of Governmental Industrial Hygienists, Inc., Cincinnati. Cytogenetic indices for assessing mutagen exposure: Life-style and chromosome alteration. in ed. by Fiserova-Bergerova,V.: Biological monitoring of exposure to industrial chemicals., 171-175 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Morimoto, K. Miura, K., Takeshita, T., Mure, K., and Inoue, C.: Springer-Verlag, Berlin. Does the genetic deficiency in ALDH2 determine the alcohol-drinking behavior and the alcohol induction of chromosome alterations in peripheral lymphocytes? in ed. by Obe, G., Natarajan, A. T.: Chromosomal aberrations. Basic and applied aspects.,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Iijima,K.,Morimoto,K.: "Quantitative analyses of the induction of chromosome aberrations and sister chromatid exchanges in human lymphocytes exposed to γーrays and MitomycinーC in combination" Mutation Res.263. 263-268 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hagihara,A.,Morimoto,K.: "Personal Health practices and attitudes toward nonsmoker's legal rights in Japan" Soc.Sci.Med.33. 717-721 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Shirakawa,T.,Morimoto,K.et al: "Specific antibodies to nickel in workers with known reactivity to cobalt" Clin.and Exp.Allergy. 22. 213-218 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Shirakawa,T.,Morimoto,K.: "Lifestyle effect on total IgEーLifestyles have a cumulative impact on controlling total IgE levels" Allergy. 46. 561-569 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kusaka,Y.,Morimoto,K.: "Reading of Japanese standard radiographs of pneumoconioses(1982)according to ILO 1980 international classification of radiographs of pneumoconioses:A pilot trial by some British readers" Brit.J.of Industr.Med.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 萩原 明人,森本 兼曩: "ライフスタイルと嫌煙権意識(第3報)" 日本衛生学雑誌. 46. 930-938 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森本 兼曩: "ライフスタイルと健康" 医学書院, 330 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森本 兼曩: "姉妹染色分体交換試験法(林真編:遺伝毒性学試験法)" 朝倉書店, 212-219 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 岡田 正喜,森本 兼曩: "UMUテストを用いた唾液の抗変異原作用の検討(第1報)ー唾液の濾過及び保存の影響の検討ー" 日本衛生学雑誌. 44. 1009-1013 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 垂水 公男,吉田 操,森本 兼曩: "運動習慣に関連する要因の検討" 松仁会医誌. 28. 193-197 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 兼曩: "遺伝素因と染色体変異感受性" 保健の科学. 31. 38-45 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 日下 幸則,横山 邦彦,瀬良 好澄,白川 太郎,後藤 稠,森本 兼曩: "法定麈肺検診のための自記式呼吸器症状ー質問票の評価ー" 産業医学. 31. 415-420 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Morimoto,K.: "Lifeーstyle and genetic factors that determine the susceptibility to production of chromosome damage.in ed.by Cbe,G.,Natarojan,A.T.:Chromsomal aberrations Basic and applied aspects." Springer・Verlag. 287-301 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Morimoto,K.: "Cytogenetic indices for assessing mutagen exposure:Lifestyle and chromosome alteration.in ed.by FiserovaーBergerva,V.,Ogata,M.:Biological monitoring of exposure to industrial chemicals." American Conference of Governmental Industrial Hygienists. 171-175 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kusaka,Y.,Nakano,Y.,Shirakawa,T.,Morimoto,K.: "Lymphocyte transformation with cobalt in hard metal asthma." Ind.Health. 27. 155-163 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shirakawa,T.,Kusaka,Y.,Fujimura,N.,Goto,S.,Kato,M.,Heki,S.,Morimoto,K.: "Occupational Asthma from Cobalt Sensitivity in Workers Exposed to Hard Metal Dust" Chest. 95. 29-37 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Okayama,A.,Morimoto,K.: "A new HPLC flucrimetric method to monitor urinary deltaーaminclevulinic acid (ALAーU) levels in workers exposed to lead." Int.Arch.Occup.Environ.Health. 61. 297-312 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 兼曩: "働く人の加齢と健康管理(1)「加齢」はなぜ今日的テ-マか" 労働衛生. 30(1). 34-38 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 兼曩: "精神的健康度ーライフスタイルとストレスー" 予防医学. 19. 3-31 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岡山 明,森本 兼曩: "分子遺伝疫学" 産業医学レビュ-. 1. 26-36 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 兼曩,丸山 総一郎,夏目 誠,小川 康恭: "産業ストレス中央災害防止協会編:心とからだの健康づくり(THP)心理相談員養成研修テキスト" 労働省中央労働災害防止協会, (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 丸山 総一郎,森本 兼曩: "ライフスタイルとQOL,QOL研究会編,Quality of LifeーQOLの目指すものー" リブロ社, (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 兼曩(監訳): "生活習慣と健康ーライフスタイルの科学" HBI出版局, 208 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森本 兼曩: "環境変異原.遺伝疫学的接近 小泉明,村上正孝編:環境保健入門" 日本評論社, (1990)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi