| Project/Area Number |
02404035
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Keio University |
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Principal Investigator |
SAKURAI Haruhiko Keio University School of Medicine Department of Preventive Medicine and Public Health, Professor, 医学部, 教授 (70051357)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Tohru Keio University School of Medicine Department of Preventive Medicine and Public, 医学部, 助手 (50153846)
OMAE Kazuyuki Keio University School of Medicine Department of Preventive Medicine and Public, 医学部, 助教授 (60118924)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥28,100,000 (Direct Cost: ¥28,100,000)
Fiscal Year 1992: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1991: ¥12,100,000 (Direct Cost: ¥12,100,000)
Fiscal Year 1990: ¥14,300,000 (Direct Cost: ¥14,300,000)
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| Keywords | Semiconductor / Toxicity / Animal / Liquid organic compounds / Tetraethoxysilane |
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| Research Abstract |
Because amount of consumption was the largest and information of toxicity was poor, toxicity of tetraethoxysilane [TEOS,Si(OC_2H_5)_4] on ICR male mice was firstly investigated.
TEOS intraperitoneal administration study showed that LD_<50> was around 500mg/kg, and the target organ was the kidney characterized by developing acute tubular necrosis (ATN) and tubulointerstitial nephritis (TIN).
Acute inhalation study (1000 ppm TEOS for 1, 2, 4 or 8 hours) indicated that LD_<50> (4 hours) was greater than 1000 ppm and that the kidney and nasal mucosa were the target organs. Subacute inhalation studies (200, 100, or 50 ppm TEOS for 6 hours/day, 5 day/week, for 2 or 4 weeks) indicated that no-effect level of TEOS inhalation on the kidney was 50 ppm and that on the nasal cavity was less than 50 ppm. From these results, exposure level should be strictly controlled below 10 ppm, the current recommended exposure limit, and that renal tubular function should be assessed and monitored long-term TEOS-exposed workers.
Time course study of TEOS effect on the kidney suggested that the kidney developed renal tubular injury until 12 hours after TEOS i.p., started to recover 3 days after TEOS i.p., and developed TIN by 2 weeks.
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