| Project/Area Number |
02404054
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
MOHRI Hitoshi Tohoku University. School of Medicine,Professor, 医学部, 教授 (60108503)
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| Co-Investigator(Kenkyū-buntansha) |
SATOU Naoshi 東北大学, 医学部附属病院, 講師 (20114499)
KOIWA Yoshirou 東北大学, 医学部, 助教授 (80091685)
NITTA Sinichi 東北大学, 抗酸菌病研究所, 助教授 (90101138)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥11,100,000 (Direct Cost: ¥11,100,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1990: ¥7,900,000 (Direct Cost: ¥7,900,000)
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| Keywords | viration / myocardial preseruation / viscoelasticity / cardiac transplantation / ドナー心 / 重症心不全 / 心補助法 / 心保存 |
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| Research Abstract |
Mechanical vibration for the therapeutic measure of severe heart disease 1.Development of monitoring measure of the myocardial preservation during open heart surgery. A transfer function method was applied for the measurement and the monitoring system consists of a vibrator, a function generator, a pair of vibration pickups and a signal processor. In the animal experiments, their heart were subjected to cardioplegic arrest with variety of myocardial temperatures from 15 30ﾟC and their viscoelasticity were measured periodically. Results of these experiments demonstrated usefulness of continuous monitoring of the myocardial viscoelasticity during open heart surgery, especially for the procedures which requires prolonged ischemic time. 2.Monitoring of the donor heart viability during simple immersion technique have been enabled by the use of measurement system of myocardial viscoelasticity. 3.Development of myocardial vidrator for the clinical use was done by the use of microsolenoid. However its clinical use would be hampered with anatomical incompatibility and currently we are planning to manufacture a system with a clinically useful design.
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