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Quantitation and investigation of malignancy of brain tumors

Research Project

Project/Area Number 02404058
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKyorin University

Principal Investigator

TAKEUCHI Kazuo (1992-1993)  Kyorin Univ. Dept. Neurosurgery Professor, 医学部, 教授 (80086462)

星野 孝夫 (1990-1991)  杏林大学, 医学部, 教授 (90010165)

Co-Investigator(Kenkyū-buntansha) SAWA Hiroki  Kyorin Univ. Dept. Neurosurgery Assistant, 医学部, 助手 (80135912)
WATANABE Takashi  Kyorin Univ. Dept. Clinical Pathology Lecturer, 医学部, 講師 (00191768)
MATSUDA Muneo  Kyorin Univ. Dept. Biology Associate Prof., 医学部, 助教授 (30190482)
NAGAMATSU Shinya  Kyorin Univ. Dept. Biochemistry Associate Prof., 医学部, 助教授 (80231489)
前田 達浩  杏林大学, 医学部, 講師 (50210993)
小松 明男  杏林大学, 医学部, 助教授 (20225569)
内ケ崎 新也  杏林大学, 医学部, 講師 (80146547)
Project Period (FY) 1990 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥32,500,000 (Direct Cost: ¥32,500,000)
Fiscal Year 1993: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1992: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1991: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1990: ¥15,100,000 (Direct Cost: ¥15,100,000)
Keywordscell kinetics / brain tumor / suppressor gene P-53 / glucose transporter / Histone / nucleolin / cell-cell adhesion molecules / MIB-1 / モノクロ-ナル抗体 / 細胞細胞接着蛋白質 / がん抑制遺伝子 / 成長因子 / 細胞細胞接着蛋白 / ガン抑制遺伝子
Research Abstract

Cell kinetics of brain tumors Double-labeling studies with BUdR and iododeoxyuridine, performed to analyze the cell cycle progression in over 50 gliomas, revealed that S-phase duration (Ts) was fairly uniform (mean +- SD : 8.9 +- 2.0 hours) regardless of the differences in the LIs. Nevertheless, the potential doubling time (the time for a tumor cell population to double in the absence of cell lose) varied from 2 days to over a month, begin very short for tumors with a high LI, and correlated withthe BUdR LIs (Tp=17.8/LI^<0.77> ; r=0.95). The cell cycle time calculated for gliomas with LIs of 1-20% was 1-2 days. These paramaters are useful in determining the dose, duration, and interval of chemotherapy and in evaluating the effectiveness of treatment. In addition, novel methods for evaluating proliferating activities of brain tumors were developed.
1) In situ hybridization for Histone 3 mRNA
2) Probuction of nucleolin antibody and its characterization
3) Clinical application of MIB-1 antibody immunohistochemistry
A tumor suppressor gene P-53 was analyzed, using a polymerase chain reaction-RFLP method. The loss of heterozygosity (LOH) was demonstrated in 48% of brain tumors.
The expression of facilitative glucose transporter (GLUT) isoforms in human astrocytic tumors was examined. GLUT1 was observed in the luminal surface of capillaries in all cases, whereas tumor cells were positive for GLUT1 in only two of 14 cases. these of 14 cases expressed the GLUT4 protein, which was localized in the cytoplasm of tumor cells.
C-CAM and K3 protein closely related to the formation of blood brain barrier function in the central nervous system.

Report

(5 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • 1990 Annual Research Report

Research Products

(79 results)

All Other

All Publications (79 results)

  • [Publications] Hoshino T,Ito S,Asai A,Shibuya M,Prados MD,Dodson BA,Davis RL,Wilson CB: "Cell kinetic analysis of human brain tumors by in situ double labelling with bromodeoxyuridine and iododeoxyuridine." Int J Cancer. 50. 1-5 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] McDermott MW,Krouwer HGJ,Asai A,Ito S,Hoshino T,Prados MD: "A comparison of CT contrast enhancement and BUdR labeling indices in moderately and highly anaplastic astrocytomas of the cerebral hemispheres." Canad J Neurol. 19. 34-39 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hoshino T,Ito S,Asai A,Prados MD,Davis RL,Wilson CB: "Cell kinetic analysis of brain tumors studied by in situ double labelling with IUdR and BUdR." J Neuro-Oncol. 13. 265 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ito S,Hoshino T,Shibuya M,Prados MD,Edwards MSB: "Cell kinetics of medulloblastomas." J Neuro-Oncol. 12. 265 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Krouwer HGJ,Davis RL,McDermott MW,Hoshino T,Prados MD: "Gangliogliomas-A review of 25 patients-." J Neuro-Oncol. 12. 266 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] McDermott MW,Krouwer HGJ,Asai A,Ito S,Hoshino T,Prados MD: "A comparison of CT contrast and BUdR labeling indices in moderate and highly anaplastic astrocytomas of the cerebral hemispheres." J Neuro-Oncol. 12. 267 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M,Ito S,Davis RL,Wilson CB,Hoshino T: "Immunohistochemical analysis of brain tumors with monoclonal antibody Ki-67,anti-DNA polymerase α monoclonal antibody and bromodeoxyuridine labelling." J Neuro-Oncol. 12. 270 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 星野孝夫: "悪性神経膠腫の最良の治療はなにか:成長解析よりみた化学療法の将来的展望。" 脳外誌. 1. 136-142 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 浅井照雄、Bodell WF、星野孝夫: "ヒト脳腫瘍におけるchloroethylnitrosourea薬剤耐性の評価法-Northern blot法による06-methylguanine-DNA metyltransferase mRNA発現量の定量。" 脳外誌. 1. 170-172 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M,Hoshino T,Ito S,Wacker MR,Prados MD,Davis RL,Wilson CB: "Meningiomas:Clinical implications of a high proliferative potential determined by bromodeoxyuridine labelling." Neurosurgery. 30. 494-498 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hoshino T,Ito S,Shibuya M,Prados MD,Wilson CB,Davis RL: "Cell kinetic analysis of gliomas studied by double labelling with iododeoxyuridine(IUdR)and bromodeoxyuridine(BUdR)." Proc Amer Assoc Cancer,Res. 33. 37 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Prados MD,Krouwer HGJ,Edwards MSB,Cogen PH,Davis RL,Hoshino T: "Proliferative potential and outcome in pediatric astrocytic tumor." J Neuro-Oncol. 13. 277-282 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hoshino T: "Cell kinetics of glial tumors." Rev Neurol(Paris). 148. 396-401 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M,Miwa T,Hoshino T: "Embedding and fixation techniques for immunohistochemical staining with anti-DNA polymerase α and Ki-67 monoclonal antibodies to analyze the proliferative potential of tumors." Biotech Histochem. 67. 161-164 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ito S,Hoshino T,Prados MD,Edwards MSB: "Cell kinetics of medulloblastomas." Cancer. 70. 671-678 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sibuya M,Sito F,Miwa T,Davis RL,Wilson CB,Hoshino T: "Histochemical study of pituitary adenomas with Ki-67 and anti-DNA polymerase α monoclonal antibodies,bromodeoxyuridine labeling,and nucleolar organizer region counts." Acta Neuropathol. 84. 178-183 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 前田達浩、星野孝夫: "Bromodeoxyuridine,iododeoxyuridine二重標識法による脳腫瘍の成長解析" 脳と神経. 44. 821-825 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Asai A,Hoshino T,Edwards MSB,Davis RL: "Prediction the recurrence of ependymomas from the bromodeoxyuridine labeling index." Child's Nerv Syst. 8. 273-278 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ito S,Hoshino T,Shibuya M,Prados MD,Edwards MSB,Davis RL: "Proliferative characteristics of juvenile astrocytomas determined by bromodeoxyuridine labeling." Neurosurgery. 31. 413-419 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S,Sawa H,Inoue N,Takeshima H,Nakamichi Y,Murakawa S,Hoshino T: "Effect of glucose on the brain specific GLUT 3 and GLUT 1 glucose transporter gene in mouse brain and primary cultured neuron from rat embryo." Diabetes 41(suppl). 158. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 永松信哉、武島英人、中道洋子、板垣英二、脇坂晟、村川章一郎、佐和弘基、星野孝夫: "マウスβTC3細胞における糖輸送担体遺伝子(Glut-1、3)およびマウスGlut-3の脳特異的発現" 分子糖尿病学. 45-51 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 鎌田孝一、佐和弘基、佐藤秀子、星野孝夫: "In situ hybridizationを用いた増殖細胞同定法。" 医学のあゆみ. 161. 951-952 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M,Ito S,Miwa T,Davis RL,Wilson C,Hoshino T: "Proliferative potential of brain tumors-Analyses with Ki-67 and anti-DNA polymerase α monoclonal antibodies,bromodeoxyuridine labeling,and nucleolar organizer region counts." Cancer. 71. 199-206 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S,Sawa H,Kamada K,Nakamichi Y,Hoshino T: "Neuron-specific glucose transporter(NSGT):CNS distribution of Glut-3 rat glucose transporter(RGT3)in rat central neurons." FEBS LETT. 334. 289-295 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S,Sawa H,Wakizaka A,Hoshino T: "Expression of facilitative glucose transporter isoforms in human brain turmor." J Neurochem. 61. 2048-2053 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 飯島淳子、佐和弘基、椎名義雄、星野孝夫: "PCRを用いたP-53遺伝子のCodon 72部位におけるポリモルフィズムの検索と脳腫瘍への応用" 脳と神経. 45(1). 43-47 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S,Sawa H,Inoue N,Nakamichi Y,Takeshima H,Hoshino T: "Gene experssion of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuromal cell cultures from rat embryo." Biochem J. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sawa H,Kamada K,Sato H,Kondo A,Saito I,Edlund M,Obrink B: "C-CAM expression in the developing rat central nervous system." Dev.Brain Res. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 佐和 弘基、星野 孝夫: "脳腫瘍の免疫と分子生物学(分担執筆pp85-93)" 金芳堂, 344 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hoshino T, Ito S, Asai A, Shibuya M, Prados MD, Dodson BA, Davis RL, Wilson CB: "Cell kinetic analysis of human brain tumors by in situ double labelling with bromodeoxyuridine and iododeoxyuridine" Int J Cancer. 50. 1-5 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] McDermott MW.Kronwer HGJ, Asai A, Ito S, Hoshino T, Prados MD: "A comparison of CT contrast enhancement and BUdR labiling indices in moderately and highly anaplastic astrocytomas of the cerebral hemispheres" Canad J Neurol. 19. 34-39 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M, Hoshino T, Ito S, Wacker MR, Prados MD, Davis RL, Wilson CB: "Meningiomas : Clinical implications of a high proliferative potential determined by bromodeoxyuridine ladelling" Neurosurgery. 30. 494-498 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Prados MD, Krouwer HGJ, Edwards MSB, Cogen PH, Davis RL, Hoshino T: "Proliferative potential and outcome in pediatric astrocytic tumor" J Neuro-Oncol. 13. 277-282 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hoshino T: "Cell kinetics of glial tumors" Rev Neurol (Paris). 148. 396-401 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sibuya M, Miwa T, Hoshino T: "Embedding and fixation techniques for immunohistochemical staining with anti-DNA polymerase alpha and Ki-67 monoclonal antibodies to analyze the proliferative potential of tumors" Biotech Histochem. 67. 161-164 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ito S, Hoshino T, Prados MD, Edwards MSB: "Cell kinetics of medulloblastomas" Cancer. 70. 671-678 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sibuya M, Sito F, Miwa T, Davis RL, Wilson CB, Hoshino T: "Histochemical study of pituitary adenomas with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nucleolar organizer region counts" Acta Neuropathol. 84. 178-183 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Asai A, Hoshino T, Edwards MSB, Davis RL: "Prediction the recurrence of ependymomas from the bromodeoxyuridine labeling index" Child's Nerv Syst. 8. 273-278 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ito S, Hoshino T, Sibuya M, Prados MD, Edwards MSB, Davis RL: "Proliferative characteristics of juvenile astrocytomas determined by bromodeoxyuridine labeling" Neurosurgery. 31. 413-419 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S, Sawa H, Inoue N, Takeshima H, Nakamichi Y, Murakawa S, Hoshino T: "Effect of glucose on the brain specific GLUT 3 and GLUT 1 glucose transporter gene in mouse brain and primary cultured neuron from rat embryo" Diabetes. 41(suppl)158. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M, Ito S, Miwa T, Davis RL, Wilson C, Hoshino T: "Proliferative potential of brain tumors-Analyzes with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nucleolar organizer region counts" Cancer. 71. 199-206 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S, Sawa H, Kamada K, Nakamichi Y, Hoshino T: "Neuron-specific glucose transporter (NSGT) : CNS distribution of Glut-3 rat glucose transporter (RGT3) in rat central neurons" FEBS LETT. 334. 289-295 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S, Sawa H, Kamada K, Nakamichi Y, Hoshino T: "Neuron-specific glucose transporter (NSGT) : CNS distribution of Glut-3 rat glucose transporter (RGT3) in rat central neurons" FEBS LETT. 334. 289-295 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S, Sawa H, Wakizaka A, Hoshino T: "Expression of facilitative glucose transporter isoforms in human brain turmor" J Neurochem. 61. 2048-2053 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Nagamatsu S, Sawa H, Inoue N, Nakamichi Y, Takeshima H, Hoshino T: "Gene expression of GLUT3 glucose transporter regulated by glucose in mouse brain and in vitro in neuronal cell cultures from rat embryo" Biochem J. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sawa H, Kamada K, Sato H, Kondo A, Saito I, Edlund M, Obrink B: "C-CAM expression in the developing rat central nervous system" Dev. Brain Res. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shibuya M,Ito S,Miwa T,Davis RL,Wilson C,Hoshino T: "Proliferative potential of brain tumors-Analyses with Ki-67 and anti-DNA polymerasea monoclonal antibodies,bromodeoxyuridine labeling,and nucleolar organizer region" Cancer. 71. 199-206 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nagamatsu S,Sawa H,Kamada K,Nakamichi.Y,Hoshino T: "Neuron-specific glucose transporter(NSGT):CNS distribution of Glut-3 rat glucose transporter(RGT3)in rat central neurons." FEBS LETT. 334. 289-295 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nagamatsu S,Sawa H,Wakizaka A,Hoshino T: "Expression of facilitative glucose transporter isotorms in human brain turmor." J Neurochem. 61. 2048-2053 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 飯島淳子、佐和弘基、椎名泰雄、星野孝夫: "PCRを用いたP-53遺伝子のCodon72部位におけるポリモルフィズムの検索と脳腫瘍への応用" 脳と神経. 45(1). 43-47 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Herold KC,Nagamatsu S,Buse JB,Kulsakdinun P,Steiner DF: "Inhibition of glucose-stimulated insulin release from betaTC3 cells and rodent islets by an analog of FK506." Transplantation. 55. 186-192 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nagamatsu S,Sawa H: "Neuron specific glucose transporter(NSGT):Cloning and cellular localization in rat brain." Diabetes.42(Suppl 1). 486 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 永松信哉: "マスウbetaTC3細胞のインスリン生合成調節機構における糖輸送担体、hexokinase、及びglucokinaseの役割。" 糖尿病記録号. (in press). (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 永松信哉、中道洋子、佐和弘基: "脳タイプのグルコーストランスポーター。" 生体の科学. (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Nagamatsu S,Sawa H,Inoue N,Nakamichi Y,Takeshima H,Hoshino T: "Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryo." Biochem J. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sawa H,Kamada K,Sato H,Kondo A,Saito I,Edlund M,Obrink B: "C-CAM expression in the developing rat central nervous system." Dev.Brain Res. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 前田 達浩,星野 孝夫: "Bromodeoxyuridine,idiodeoxyuridine二重標識法による脳腫瘍の成長解析" 脳と神経. 9. 821-825 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Satoyuki Ito,Takao Hoshino Michael D Prados: "Cell kinetics of medulloblastomas" Cancer. 70. 671-678 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takao Hoshino: "Cell kinetics of glial tumor" Rev.Neurol(Paris). 148. 396-401 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 鎌田 孝一,佐和 弘基,佐藤 秀子,星野 孝夫: "In situ hybridization法を用いた増殖細胞の同定法" 医学のあゆみ. 161. 951-952 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 永松 信哉,武島 英人,中道 洋,板垣 英二,脇坂 晟,村井 章一郎,佐和 弘基,星野 孝夫: "マウスβTC3細胞における糖輸送担体遺伝子(Glut1,3)およびマウスGlut3の脳特異的発現" 分子糖尿病学. 45-51 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 飯島 淳子,佐和 弘基,椎名 義雄,星野 孝夫: "PCRを用いたP53遺伝子のcodon72部位におけるポリモルフィズムの検索と脳腫瘍への応用" 脳と神経. 45. 43-47 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐和 弘基,星野 孝夫: "脳腫瘍の免疫と分子生物学(分担執筆pp85-93)" 金芳堂, 344 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takao Hoshino: "proliferative potential of astrocytomas and glioblastomas" 脳腫瘍病理. 8. 163-166 (1991)

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      1991 Annual Research Report
  • [Publications] 星野 孝夫: "脳腫瘍の細胞増殖能について" 病理と臨床. 9. 620-627 (1991)

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      1991 Annual Research Report
  • [Publications] T Hoshino,S Ito,A Asai,M Sibuya,MD prados,BA Dodson,RL Davis CB Wilson: "Cell Kinetic analysis of human brain tumors by in situ double labelling with bromodesxy widine and ldodeoxyuridine" Int.J.Cancer. 50. 1-5 (1992)

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      1991 Annual Research Report
  • [Publications] 星野 孝夫: "BrdU(bromodeoxyuridine)ー脳腫瘍への応用" 病理と臨床. 9. 826-867 (1991)

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      1991 Annual Research Report
  • [Publications] 鎌田 孝一,佐和 弘基,佐藤 秀子,星野 孝夫: "in situ hybridization法を用いた増殖細胞野同定法" 医学のあゆみ.

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      1991 Annual Research Report
  • [Publications] Takao Hoshino: "K Tabuchi (ed)“Biological Aspects of Brain Tumors"" SpringerーVerlag,Tokyo, 503 (1991)

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      1991 Annual Research Report
  • [Publications] S Shibui,R Nishikawa,K Nomura,K Iwaki,T Maeda,T Hoshino: "K Tabuchi(ed)“Biological Aspects of Brain Tumors"" SpringerーVerlag,Tokyo, 503 (1991)

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      1991 Annual Research Report
  • [Publications] K Nomura,T Hoshino: "II.Applications in clinical oncology.11.CNS Tumors(Adult)" In KD Bauer,RE Duque,TV Shankey(eds),“Flow Cytometry:Principles and clinical Application",Williams & Winkins,Baltimore,

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      1991 Annual Research Report
  • [Publications] T Hoshino: "P Paosetti et al(eds)“NeuroーOncology"" Kluwer Academic Publishers,Dordrecht, 406 (1991)

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  • [Publications] 星野 孝夫: "病態診断の進歩" 癌と化学療法. 18. 160-167 (1991)

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  • [Publications] 星野 孝夫: "Proliferative potential of astrocytomas and glioblastomas" 脳神経病理.

    • Related Report
      1990 Annual Research Report
  • [Publications] 星野 孝夫: "脳腫瘍の細胞増殖能について" 病理と臨床.

    • Related Report
      1990 Annual Research Report
  • [Publications] Takao Hoshino: "Cell kinetics of brain tumors and its clinical relevance" In K Tabuchi ed.,Proceeding of Nikko Brain Tumor Conference,SpringerーVerlag,Tokyo,

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      1990 Annual Research Report
  • [Publications] S Shibui,R Nishikawa,K Nomura,K Iwasaki,T Maeda,T Hoshino: "Double labeling method with BUdR and IUdR for cell kinetic studies of brain tumors" In K Tabuchi ed.“Proceedings of the Nikko Brain Tumor Conference,SpringerーVerlag,Tokyo,

    • Related Report
      1990 Annual Research Report
  • [Publications] K Nomura,T Hoshino: "II.Applications in clinical oncology.11.CNS Tumors(Adult)" In KD Bauer,RE Duque,TV Shankey(eds),“Flow Cytometry:Principles and clinical Appliation",Williams & Wilkins,Baltimore,

    • Related Report
      1990 Annual Research Report
  • [Publications] Takao Hoshino: "Proliferative potential of astrocytomas and glioblastomas" In P Paoletti ed.,“Pecent Advances in Neurooncology"Kluwer Academic Publishers,Dordrecht,

    • Related Report
      1990 Annual Research Report

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Published: 1990-03-31   Modified: 2016-04-21  

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