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Study of Sexual Function in Middle High Aged Male

Research Project

Project/Area Number 02404065
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionSapporo Medical College

Principal Investigator

KUMAMOTO Yoshiaki  Dept. of Urology, Sapporo Medical College, Professor, 医学部, 教授 (40045323)

Co-Investigator(Kenkyū-buntansha) AOKI Masaharu  Dept. of Urology, Sapporo Medical College, Instructor, 医学部, 助手 (10167794)
KIKUMA Naohito  Dept. of Urology, Sapporo Medical College, Instructor, 医学部, 助手 (30190614)
SATOH Yoshikazu  Dept. of Urology, Sapporo Medical College, Instructor, 医学部, 助手 (50235420)
ITOH Naoki  Dept. of Urology, Sapporo Medical College, Instructor, 医学部, 助手 (60193504)
斉藤 誠一  札幌医科大学, 医学部, 助手 (80215540)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1990: ¥6,400,000 (Direct Cost: ¥6,400,000)
Keywordsmale "climacterium" / unidentified complaints syndrome / penile vascular disorder / penile neurological disorder / decrease of dopamine level in brain / 性は脳なり / 札幌大式性機能質問調査用紙 / 加齢性性機能低下 / 糖尿病性性機能低下 / 腎障害性性機能低下 / 脳内ド-パミン / 脳内アセチ-ルコリン / 性機能 / ストレス / ド-パミン
Research Abstract

As we have been reaching to high age society, medical interest has focused on the quality of life in the aged people. In this connection, a maintenance of male sexual function has been a topic of society. However, when we discussed male sexual dysfunction of the aged people, we need a data on standard of the sexual function by age in Japanese people. Thus, we conducted a survey on sexual function of male, of which results showed that the male sexual function gradually declined at the age of 50. The study on factors which accelerate male sexual dysfunction in "climacterium" revealed that psycological stress played an important role in the dysfunction. The decline of male sexual function correlated with a severity of unidentified complaints syndrome, which are often seen in"female climacterium".
We were able to identify in experimental studies in rat that male sexual dysfunction may depend on a decrease of dopamine level in hypothalamic area, particularly, sex center, the decrease which w … More ere also accelerated by psychological stress. Penile-vacular disorder was revealed to be the most influential factor on gradually and physiologically progressive decrease of sexual function in the aged people of more than 60. Neurological disorder was an influential factor. However, in patients with diabetes or those receiving dialysis, they were found to have not only more accelerated penile vascular disorder but also severe neurological dysfunction. It should be emphasized that sexual dysfunction in aged male is often associated with disorder of peripheral organs and also with a decrease of dopamine level in the brain, which is seen in "male climacterium". Since a positive correlation of dopamine level with serum testosterone is commonly found, testicular endocrine dysfunction by age seems indirectly to influence on sexual dysfunction in the aged people.
Thus, an administration of l-dopa on the aged improved to some extent the sexual dysfunction, suggesting that dopamine level is partly related to the sexual dysfunction in the aged people. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 三熊 直人: "思春期発来時期における夜間睡眼時Luteinizing hormone分泌パタ-ンの変化についてー高感度Immunofluorometric assay(IFMA)を用いた検討ー" 日本内分泌学誌. 66. 1085-1093 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 熊本 悦明: "臨床男性科学のめざすもの" 日本泌尿器科学会誌. 81. 1957-1966 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 青木 正治: "加齢による勃起機能低下の背景因子の分析ー夜間睡眼時勃起現象、prnile blood pressure indexおよび塩酸パパベリンテストによる検討ー" 日本泌尿器科学会誌. 81. 1633-1641 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 熊本 悦明: "男性更年期の臨床的問題点" 日本医師会雑誌. 106. 372-378 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 熊本 悦明: "加齢と男性性機能" 内分泌学の進歩. 9. 177-196 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 堀田 浩貴: "小児における夜間睡眠時勃起現象の測定の意義" 日本泌尿器科学会誌. 82. 1939-1946 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yoshikazu Satoh, Yoshiaki Kumamoto and Nobukazu suzuki: "Psychological stress and sexual behavior in male rats. I. Sexual behavior in rats undergoing psychological or physical stress." Jpn. J. Urology. 83. 205-211 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yoshikazu Satoh and Yoshiaki Kumamoto: "Psychological stress and sexual behavior in male rats. II. Effect of psychological stress on dopamine and its metabolities in the critical brain areas mediating sexual behavior." Jpn. J. Urology. 83. 212-219 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naohito Mikuma, Yoshiaki Kumamoto and Hiroshi Maruta: "The aging of hypothalamo-pituitary-testicular axis. I : Hypothalamic function in male senescence" Jpn. J. Fert. Steril.36. 648-654 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naohiton Mikuma, Yoshiaki Kumamoto and Hiroshi Maruta: "The aging of hypothalamo-pituitary-testicular-axis. II. Anterior pituitary function in male senescence" Jpn. J. Fert. Steril.36. 854-858 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naohito, Mikuma, Yoshiaki Kumamoto and Hiroshi Maruta: "The aging of hypothalamo-pituitary-testicular-axis. III. Testicular endocrine function in male senescence." Jpn. J. Fert. Steril.37. 152-156 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naohito Mikuma, Hideki Wada and Yoshiaki Kumamoto: "Nocturnal luteinizing hormone secretion patterns at the onset of puberty" Folia Endocrinolo.66. 1085-1093 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masaharu Aoki and Yoshiaki Kumamoto: "Analyses of factors contributing to the erectile dysfunction with aging by nocturnal penile tumescence, penile blood pressure index and papaverine test." Jpn. J. Urol.81. 1633-1641 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yoshiaki Kumamoto: "Prospects of clinical andrology" Jpn. J. Urol.81. 1957-1966 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroki Horita, Yoshiaki Kumamoto, Masaharu Aoki, et al.: "Clinical significance and usefulness of measuring nocturnal penile tumescence in children." Jpn. J. Urol.82. 1939-1946 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 三熊 直人: "視床下部ー下垂体ー精巣系の老化(第1報):視床下部機能の老化の研究" 日本不妊学会誌. 36. 648-654 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三熊 直人: "視床下部ー下垂体ー精巣系の老化(第2報):下垂体機能の老化の研究" 日本不妊学会誌. 36. 854-858 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三熊 直人: "視床下部ー下垂体ー精巣系の老化(第3報):精巣機能の老化の研究" 日本不妊学会誌. 37. 152-156 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 佐藤 嘉一: "心理的ストレス負荷ラットの性行動の研究(第1報):ストレス負荷ラットによる性行動変化の検討" 日本泌尿器科学会誌. 83. 205-211 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 佐藤 嘉一: "心理的ストレス負荷ラットの性行動の研究(第2報):雄型性行動の神経回路における脳内dopamine動態変化の検討" 日本泌尿器科学会誌. 83. 212-219 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 熊本 悦明: "加齢と男性性機能低下" Gerontology. 4. 31-40 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 熊本 悦明: "男性更年期" カレントテラピ-. 8. 23-32 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 丸田 浩、熊本 悦明、青木 正治ほか: "性機能からみた男子更年期" ホルモンと臨床. 38. 101-110 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 青木 正治、熊本 悦明: "加齢による勃起機能低下の背景因子の分析ー夜間睡眠時勃起現象、penile blood pressure indexおよび塩酸パパベリンテストによる検討ー" 日本泌尿器科学会誌. 81. 1633-1641 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 伊藤 直樹、熊本 悦明ほか: "活性型androgenとしての血中遊離testosteroneの検討" 日本内分泌学雑誌. 67. 23-32 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 伊藤 直樹、熊本 悦明ほか: "高(estradiol/testosterone)比の乏精子症に対するtestolactone(aromatase inhibitor)の治療効果" 日本泌尿器科学会誌. 82. 204-209 (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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