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Mechanism of Synthesis and Secretion of Growth Hormone and its Mode of Actions in Telest Fishes

Research Project

Project/Area Number 02405003
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionThe University of Tokyo

Principal Investigator

HIRANO Tetsuya  Univ. Tokyo, Ocean Res. Insti., Prof, 海洋研究所, 教授 (70013571)

Co-Investigator(Kenkyū-buntansha) KANEKO Toyoji  Univ. Tokyo, Ocean Res. Inst., Assis. Prof., 海洋研究所, 助手 (70221190)
AIDA Katumi  Univ. Tokyo, Fac. of Agr., Prof, 農学部, 教授 (50012034)
KAWAUTI Hiroshi  Kitasato Univ, School of Fish., Prof, 水産学部, 教授 (70050523)
浦野 明央  東京大学, 海洋研究所, 教授 (00142232)
Project Period (FY) 1990 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥21,900,000 (Direct Cost: ¥21,900,000)
Fiscal Year 1993: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1991: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1990: ¥10,000,000 (Direct Cost: ¥10,000,000)
KeywordsFishes / Growth hormone / Prolactin / Somatolactin / Receptor / Mode of action / Migration / Osmoregulation / 性成熟
Research Abstract

The aim of this research project is to clarify mechanisms of secretion and mode of action of growth hormone(GH)and related peptides, prolactin(PRL)and somatolactin(SL), in teleost fishes with special reference to their life stages and environmental salinity. During the last 4 years, the following results were obtained.
1.GH, PRL and SL were purified from pituitaries of various teleost species, and their amino acid sequences as well as the base sequences of cDNAs were determined.
2.Specific radioimmunoassay, radioreceptorassay and in situ hybridization methods were established to monitor plasma and pituitary hormone levels and to quantify the levels of gene expression for each of he hormones.
3.Based on plasma kinetic studies and secretion of the hormones from organcultured pituitary, it has become clear that GH plays an important role in seawater adaptation of salmonid fishes, besides growth promotion.
4.PRL's freshwater-adapting effects are well established in various species used in this study. On the other hand, SL seems to be involved in calcium and lipid metabolism as well as in acid-base balance.
5.As in mammals, GH's action is exerted primarily by inducing the production of insulin-like growth factor(IGF-I)in the liver also in teleosts. However, seawater-adapting effects of GH are likely to be caused by locally-produced IFG-I in the gill, possibly inducing the differentiation of the chloride cells.

Report

(5 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (70 results)

All Other

All Publications (70 results)

  • [Publications] Sakamoto,T.,T.Ogasawara and T.Hirano: "Growth hormone kinetics during adaptation to hyperosmotic environment of rainbow trout." J.Comp.Physiol.B. 160. 1-6 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.and Y.Inui: "Effects of recombinant eel growth hormone on the uptake of [35S] sulfate by ceratobranchial cartilages of the Japanese eel." Gen.Comp.Endocrinol.79. 320-325 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.and Y.Inui: "Evidences for the presence of a somatomedin-like plasma factor(s) in the Japanese eel." Gen.Comp.Endocrinol.79. 326-331 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.and T.Hirano: "Stimulation of 35S-sulfate uptake by mammalian insulin-like growth factors I and II in cultured cartilages of the Japanese eel." J.Exp.Zool.256. 347-350 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Rand-Weaver,M.,B.I.Baker and H.Kawauchi: "Cellular localization of somatolacatin in the pars intermedia of some teleost fish." Cell Tissue Res.263. 207-216 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto,T.,M.Iwata and T.Hirano: "Kinetic studies of growth hormone and prolactin during adaptation of coho salmon,Oncorhynchus kisutch,to different salinities." Gen.Comp.Endocrinol.82. 184-191 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.and T.Hirano: "Plasma kinetics of growth hormone in the Japanese eel." Aquaculture. 95. 179-188 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirano T.: "Hepatic receptors for homologous growth hormone in the eel." Gen.Comp.Endocrinol.81. 383-390 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto.T.and T.Hirano: "Growth hormone receptors in liver and osmoregulatory organs of rainbow trout:Characterization and dynamics during seawater adaptation." J.Endocrinol.130. 425-433 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] McCormick,T.Sakamoto,S.Hasegawa and T.Hirano: "Osmoregulatory actions of insulin-like growth factor-I in rainbow trout." J.Endocrinol.130. 87-92 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mori,I.,T.Sakamoto and T.Hirano: "Growth hormone-dependent hepatic GH receptors in the Japanese eel:Effects of hypophysectomy and GH injection." Gen.Comp.Endocrinol.85. 385-391 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirano,T.,T.Sakamoto and I.Mori: "Hepatic growth hormone receptors in the eel and trout." Oceanis. 18. 99-107 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.and T.Hirano: "Effects of insulin-like growth factor-I and insulin on the in vitro uptake of sulphate by eel branchial cartilage:evidence for the presence of independent hepatic and pancreatic sulphation factors." J.Endocrinol.133. 211-219 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.,T.Noso,S.Moriyama,H.Kawauchi and T.Hirano: "Eel insulin:Isolation,characterization and simulatory actions on [35S]sulphate and [3H]thymidine uptake in the branchial cartilage of the eel." J.Endocrinol.133. 221-230 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arakawa,E.,T.Kaneko,K.Tsukamoto and T.Hirano: "Immunocyto-chemical detection of prolactin and growth hormone cells in the pituitary during early development of the Japanese eel." Zool.Sci.9. 1061-1066 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naito,N.,E.G.de Jesus,Y.Nakai and T.Hirano: "Ontogeny of piutuitary cell-types and the hypohtalamo-hypophysial relationship during early development of chum salmon." Cell Tiss.Res.272. 429-437 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan,C.,N.Hanzawa,Y.Takeuchi,E.Hamada,S.Miyachi and T.Hirano: "Use of primary cultures of salmon hepatocytes for the study of hormononal regulation of insulin-like growth factaor I expresasion." Zool.Sci.10. 473-480 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto,T.and T.Hirano: "Expression of insulin-like growth factor I gene in osmoregulatory organs during seawater adaptation of the salmonid fish:Possible mode of osmoregulatory action of growth hormone." Proc.Natl.Acad.Sci.USA. 90. 1912-1916 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto,T.,S.D.McCormik and T.Hirano: "Osmoregulatory actions of growth hormone and its mode of action in salmonids:A review." Fish Physiol.Biochem.11. 155-164 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko,T,S.Kakizawa and T.Yada: "Pituirary of Cobalt variant of the rainbow trout separated from the hypothalamus lacks most pars intermedial and neurohypophysial tissue." Gen.Comp.Endocrinol.92. 31-40 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kakizawa,S.,T.Kaneko,S.Hasegawa,and T.Hirano: "Activation of somatolactin cells in the pituitary of the rainbow trout by low environmental calcium." Gen.Comp.Endocrinol.91. 298-306 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko,T.and T.Hirano: "Role of prolactin and somatolactin in calcium regulation in fish." J.Exp.Biol.184. 31-45 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] de Jusus,E.G.,T.Hirano and Y.Inui: "The antimetamorphic effect of prolactin in the Japanese flounder." Gen.Comp.Endocrinol.93. 44-50 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto, T., T.Ogasawara and T.Hirano: "Growth hormone kinetics during adaptation to hyperosmotic environment of rainbow trout" J.Comp. Physiol. B160. 1-6 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C.and Y.Inui: "Effects of recombinant eel growth hormone on the uptake of [35S]sulfate by ceratobranchial cartilages of the the Japanese eel" Gen. Comp. Endocrinol. 79. 320-325 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C.and Y.Inui: "Evidences for the presence of a somatomedin-like plasma factor(s) in the Japanese eel" Gen. Comp. Endocrinol. 79. 326-331 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C.and T.Hirano: "Stimulation of 35S-sulfate uptake by mammalian insulinlike growth factors I and II in cultured cartilages of the Japanese eel" J.Exp. Zool. 256. 347-350 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Rand-Weaver, M., B.I.Baker and H.Kawauchi: "Cellular localization of somatolacatin in the pars intermedia of some teleost fish" Cell Tissue Res. 263. 207-216 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto, T., M.Iwata and T.Hirano: "Kinetic studies of growth hormone and prolactin during adaptation of coho salmon, Oncorhynchus kisutch, to different salinities" Gen. Comp. Endocrinol. 82. 184-191 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C.and T.Hirano: "Plasma kinetics of growth hormone in the Japanese eel" Aquaculture. 95. 179-188 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirano T.: "Hepatic receptors for homologous growth hormone in the eel" Gen. Comp. Endocrinol. 81. 383-390 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto. T.and T.Hirano: "Growth hormone receptors in liver and osmoregulatory organs of raindow trout : Characterization and dynamics during seawater adaptation" J.Endocrinol. 130. 425-433 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] McCormick, T.Sakamoto, S.Hasegawa and T.Hirano: "Osmoregulatory actions of insulin-like growth factor-I in raindow trout" J.Endocrinol. 130. 87-92 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mori, I., T.Sakamoto and T.Hirano: "Growth hormone-dependent hepatic GH receptors in the Japanese eel : Effects of hypophysectomy and GH infection" Gen. Comp. Endocrinol. 85. 385-391 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hirano, T., T.Sakamoto and I.Mori: "Hepatic growth hormone receptors in the eel and trout" Oceanis. 18. 99-107 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C.and T.Hirano: "Effects of insulin-like growth factor-I and insulin on the in vitro uptake of sulphate by eel branchial cartilage : evidence for the presence ofindependent hepatic and pancreatic sulphation factors" J.Endocrinol. 133. 211-219 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C., T.Noso, S.Moriyama, H.Kawauchi and T.Hirano: "Eel insulin : Isolation, characterization and simulatory actions on [35S]sulphate and [3H]thymidine uptake in the branchial cartilage of the eel" J.Endocrinol. 133. 221-230 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arakawa, E., T.Kaneko, K.Tsukamoto and T.Hirano: "Immunocyto-chemical detection of prolactin and growth hormone cells in the pituitary during early development of the Japanese eel" Zool. Sci. 9. 1061-1066 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Naito, N., E.G.de Jesus, Y.Nakai and T.Hirano: "Outogeny of piutuitary cell-types and the hypohtalamo-hypophysial relationship during early development of chum salmon" Cell Tiss. Res. 272. 429-437 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Duan, C., N.Hanzawa, Y.Takeuchi, E.Hamada, S.Miyachi and T.Hirano: "Use of primary cultures of salmon hepatocytes for the study of hormononal regulation of insulin-like growth factaor I expresasion" Zool. Sci. 10. 473-480 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto, T.and T.Hirano: "Expression of insulin-like growth factor Igene in osmoregulatory organs during seawater adaptation of the salmonid fish : Possible mode of osmoregulatory action of growth hormone" A review. Fish Physiol. Biochem. 90. 1912-1916 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sakamoto, T., S.D.McCormik and T.Hirano: "Osmoregulatory actions of growth hormone and its mode of action in salmonids" A review. Fish Physiol. Biochem. 11. 155-164 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko, T, S.Kakizawa and T.Yada: "Pituirary of Cobalt variant of the rainbow trout separated from the hypothalamus lacks most pars intermedial and neurohypophysial tissue" Gen. Comp. Endocrinol. 92. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko, T, S.Kakizawa and T.Yada: "Pituirary of Cobalt variant of the rainbow trout separated from the hypothalamus lacks most pars intermedial and neurohypophysial tissue" Gen. Comp. Endocrinol. 92. (1993)31-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kaneko, T.and T.Hirano: "Role of prolactin and somatolactin in calcium regulation in fish" J.Exp. Biol. 184. 31-45 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] de Jusus, E.G., T.Hirano and Y.Inui: "The antimetamorphic effect of prolactin in the Japanese flounder" Gen. Comp. Endocrinol. 93. 44-50 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ayson,F.G.et al.: "Effects of acclimation to hypertonic environment on plasma and pituitary levels of two prolactin and growth hormone" General Comparative Endocrinology. 89. 138-148 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakata,S.et al.: "Flounder growth hormone;Isolation,characterization and effects on growth of juvenile rainbow trout" General Comparative Endocrinology. 89. 396-404 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Moriyama,S.et al.: "Oral administration of recombinant chum salmon growth hormone to rainbow trout,Oncorhynchus mykiss" Aquaculture. 112. 99-106 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakamoto,T.et al.: "Osmoregulatory actions of growth hormone and its mode of action in salmonids:A review" Fish Physiology and Biochemistry. 11. 155-164 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sakamoto,T.et al.: "Expression of insulin-like growth factor I gene in osmoregulatory organs during seawater adaptation of the salmonid fish" Proceedings of the National Academy of Science USA. 90. 1912-1916 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yada,T.et al.: "Changes in plasma levels of two prolactins and growth hormone during adaptation todifferent salinities in tilapia" General Comparative Endocrinology. 93(in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hirano,T.et all.: "Hepatic growth hormone receptors in the eel and trout" Oceanis. 18. 92-107 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mori,I.et al.: "Growth Hormone(GH)-dependent hepatic GH receptors in the Japanese eel,Anguilla japonica;Effects of hyppophysectomy and GH injection" General Comparative Endocrinology. 85. 55-61 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yada,T.and T.Hirano: "Ingibition of growth hormone synthesis by domatostatin in cultured pituitary of rainbow trout" Zoological Science. 9. 143-148 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arakawa,e.et al.: "Immunocytochemical detection of prolactin and growth hormone cells in the pituitary during early gevelopment of the Hapanese eel,Anguilla japonica" Zoological Science. 9. 1061-1066 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Varnavsky,V.S.et al.: "Stunting of wild coho salmon(Oncorhynchus Kesutch)in seawater;patterns of plasma thyroid hormones,cortisol and growth gormone" Canadian Jounal of Fisheries and Aquatic Sciences. 49. 458-461 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yada,T.et al.: "Changes en growth horone and prolactin messenger ribonucleic acid levels during seawater adaptation of amago(Oncorhynchus rhodurrs)" The Journal of Experimental Zoology. 262. 420-425 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Duan,C.and T.Hirano: "Stimulation of^<35>Sーsulfate uptake by mammalian insulinーlike growth factors I and II in cultured cartilages of the Japanese eel,Anguilla japonica." J.Exp.zool.256. 347-350 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,R.et.al.: "Isolation and characterization of Japansese eel prolactin" Gen.Comp.Endocrinol.81. 391-402 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hirano,T.: "Hepatic receptors for homologous growth hormone in the eel" Gen.Comp.Endocrinol.81. 383-390 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Sakmoto,T.et al: "Kinetic studies of grwoth hormone and prolactin during adaptation of coho salmon,Oncorhynchus kisutch,to different salinities" Gen.Comp.Endocrinol.82. 184-191 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,R.and T.Hirano: "Development of a homologus radioimmunoassay for eel prolactin" Gen.Comp.Endocrinol.81. 403-409 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,R.et al.: "Effects of osmotic pressure on prolactin and growth hormone secretion from organーcultured eel pituitary" J.Comp.Physiol.B. 161. 147-153 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hirano,T.et al.: "Changes in plasma hormone levels during loss of hypoosmoregulatory capacity in mature chum salmon (Oncorhynchus keta)kept in seawater" Gen.Comp.Endocrinol.78. 254-262 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Suzuki,R.et al.: "Growth hormone secretion during long term incubation of the pituitary of the japanese eel,Anguilla japonica." Fish Physiol Biochem. 8. 159-165 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sakamoto,T.et al.: "Growth hormone kinetics during adaptation to hyperosmotic environment of rainbow trout,Salmo gairdneri" J.Comp.Physiol.B. 160. 1-6 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Moriyama,S.et al.: "Salmon growth hormone can be transported into the circulation of rainbow trout,Salmo gairdneri after intestinal adminstration" J.Comp.Physiol.B. 160. 251-257 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Moriyama,S.et al.: "Growth stimulation of juvenile salmonids by immersion in recombinant salmon grwoth hormone" Nippon Suisan Gakkaishi. 56. 31-34 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takahashi,A.et al.: "Plasma profiles of the Nーterminal peptide of proopiomelanocortin in the rainbow trout with reference to stress" Gen.Comp.Endocrinol.77. 98-106 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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