Neurospychological Studie of the Mechanism of Higher Brain Function Using Brain Damaged Patients with Pure Syndrome
| Project/Area Number |
02451012
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWACHI Juro The University of Tokyo Professor, 教養学部, 教授 (30083710)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Mitsuru Chiba University Medical School, 医学部, 助手 (20161375)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | pure word dumbness / prosopagnosia / lingual gyrus / fusiform gyrus / apraxia / abnormal grasping / 道順障害 / 舌状回・紡錘状回 / 純粋失読 / 漢字・仮名 / 左手の失行 / 辺緑葉後部皮質 / 中心前回下部 / 語唖 / 半球内離断 / 半球間離断 / PET / MRI / 記憶障害 |
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| Research Abstract |
We investigated many brain damaged patients including several types of pure syndrome and obtained following results.
1)A 60-year-old, right-handen man suddenly developed severe pure word dumbness and slight dysgraphia. CT obtained in the second day of symptom shows a well defined old infarcrtion in the right frontal lobe. MRI reveals the lesion localized in the lower part of the precentrasl gyrus and pars opacularis of the third frontal gyrus, and also new infarction in the lower part of the left prefrontal gyrus. It is obvious that the first infarction in the right frontal lobe did not show any symptom and the second infarction occured in the similar parts of the-left hemisphere ca used severe pure word dumbness.
2)Four prosopagnosic patients, two were bilateral and two were unilateral infarction in the teritory of the posterior cerebrtal artery, were investigated with several visuo-perceptual tests including familiar and unfamiliar faces. The results indecated that(1)the prosopagnosia can be occured as a isolated symptom without any other visuo-perceptual and vvisuo-cognitive deficits, (2)the prosopagnosia can be occured after unilateral right occipitotemporal lesion including lingual and fusiform gyrie. As the mechanism of the prosopagnosia, it was suggested that the memories of the familiar faces stored in the temporal visual association cortex were not activated by the visual inputs processed adequately in the visual cortices.
Besides those patients we investigated several other patients including a pure alexic showing selective impairment of KANA reading, a left-hand apraxic and a patient with left-hand abnormal grasping both had a long and narrow infarction in the centrume semiovale along the longitudinal cerebral fissure, two patients with topographical memory loss after right unilateral infarction in the retrosplenial cortex etc.
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Report
(3 results)
Research Products
(23 results)
