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Neurospychological Studie of the Mechanism of Higher Brain Function Using Brain Damaged Patients with Pure Syndrome

Research Project

Project/Area Number 02451012
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Psychology
Research InstitutionThe University of Tokyo

Principal Investigator

KAWACHI Juro  The University of Tokyo Professor, 教養学部, 教授 (30083710)

Co-Investigator(Kenkyū-buntansha) KAWAMURA Mitsuru  Chiba University Medical School, 医学部, 助手 (20161375)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordspure word dumbness / prosopagnosia / lingual gyrus / fusiform gyrus / apraxia / abnormal grasping / 道順障害 / 舌状回・紡錘状回 / 純粋失読 / 漢字・仮名 / 左手の失行 / 辺緑葉後部皮質 / 中心前回下部 / 語唖 / 半球内離断 / 半球間離断 / PET / MRI / 記憶障害
Research Abstract

We investigated many brain damaged patients including several types of pure syndrome and obtained following results.
1)A 60-year-old, right-handen man suddenly developed severe pure word dumbness and slight dysgraphia. CT obtained in the second day of symptom shows a well defined old infarcrtion in the right frontal lobe. MRI reveals the lesion localized in the lower part of the precentrasl gyrus and pars opacularis of the third frontal gyrus, and also new infarction in the lower part of the left prefrontal gyrus. It is obvious that the first infarction in the right frontal lobe did not show any symptom and the second infarction occured in the similar parts of the-left hemisphere ca used severe pure word dumbness.
2)Four prosopagnosic patients, two were bilateral and two were unilateral infarction in the teritory of the posterior cerebrtal artery, were investigated with several visuo-perceptual tests including familiar and unfamiliar faces. The results indecated that(1)the prosopagnosia can be occured as a isolated symptom without any other visuo-perceptual and vvisuo-cognitive deficits, (2)the prosopagnosia can be occured after unilateral right occipitotemporal lesion including lingual and fusiform gyrie. As the mechanism of the prosopagnosia, it was suggested that the memories of the familiar faces stored in the temporal visual association cortex were not activated by the visual inputs processed adequately in the visual cortices.
Besides those patients we investigated several other patients including a pure alexic showing selective impairment of KANA reading, a left-hand apraxic and a patient with left-hand abnormal grasping both had a long and narrow infarction in the centrume semiovale along the longitudinal cerebral fissure, two patients with topographical memory loss after right unilateral infarction in the retrosplenial cortex etc.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 河内 十郎: "失語の象微機能障害" 失語症研究. 10. 18-26 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河内 十郎: "神経心理学における純粋型症例研究の意義" 神経心理学. 8. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河村 満: "左視床前部限局梗塞性病変における読み書き障害" 脳と神経. 42. 65-72 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河村 満: "純粋失読・純粋失書・失語失書の病態" 神経心理学. 6. 16-24 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河村 満: "文字の視覚的認知" 神経研究の進歩. 35. 479-488 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河村 満: "右手の習熟行為の解放現象" 臨床神経学. 31. 489-493 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河内 十郎: "脳損傷後の視覚認知障害" サイエンス社, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河内 十郎: "記憶の障害" 培風館, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] J. KAWACHI: "Disorders of symbolic functions in aphasics." Higher Brain Function Research. 10. 18-26 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. KAWAMURA: "Logitudinal X-ray computed tomography study of a patien with Marchiafava disease." Chiba Medical Journal. 66. 37-43 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. KAWAMURA: "Disorders of reading and writing after focal infarction in left anthrior thalamus." Brain and Nerve. 42. 65-72 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. KAWAMURA: "Localozation and symptomatology of pure alexia, pure agraphia and alexia with agraphia." japanese Journal of Neuropsychology. 6. 16-24 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. KAWAMURA: "Visual recognition of characters." Advances in neurological Sciences. 35. 479-488 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. KAWAMURA: "Release phenomenon of the skilled actions in the right hand." Journal of Clinical Neurology. 31. 489-493 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河内 十郎: "神経心理学における純粋型症例研究の意義" 神経心理学. 8. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河村 満: "文字の視覚的認知" 神経研究の進歩. 35. 479-488 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河村 満: "右手の習熟行為の解放現象" 臨床神経学. 31. 489-493 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河内 十郎: "脳損傷後の視覚認知障害" サイエンス社, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河内 十郎 他: "記憶の障害" 培風館, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 河内 十郎: "失語症の象徴機能障害" 失言症研究. 10. 18-26 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 河村 満: "純粋失読・純粋失書・失読失書の病態" 神経心理学. 6. 16-24 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 河内 十郎: "脳損傷後の視覚認知障害" サイエンス社, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 河内 十郎 他: "記憶の障害" 培風館, (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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