|Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥6,000,000 (Direct Cost: ¥6,000,000)
Although polyfunctionalized indolizine and pyrazolo[1, 5-a]pyridine derivatives were prepared and many intra- and intermolecular reactions using them were examined, their transformations to initially planned tricyclic indolizines and pyrazolo[1, 5-a]pyridines were unsuccessful. During these reaction, however, new methods for the introduction of 2-alkylamino and 2-acylmethoxy groups to these heterocycles were developed, and a new fused indolizine, 2, 3-dihydrooxepino [2, 3-b] indolizine, was also obtained by the alkaline treatment of 1- (2, 2-diacetylvinyl) -2- (adylmethoxy) indolizine. In the studies on the reactivity of the 1- and 3-. substituents in the transformations from indolizines to thienoindolizines, the order (3-CN<I-CN<3-Ester<I-Ester) was finally established. Furthermore, the structures of pyrido [2, 1-c] [1, 4] thiazine, thieno [3, 2-alindolizine, thieno [2, 3-blindolizine, pyrano [2, 3-blindolizine, and furo [2, 3-blindolizines were examined by their single crystal X-ray analyses and their valuable structural data were obtained.