| Project/Area Number |
02453139
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
OGASAWARA Kunio Tohoku University Pharmaceutical Institute Associate Professor, 薬学部, 助教授 (60004602)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1990: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | enantiocontrolled synthesis / chiral acetylene alcohol / chiral building block / natural product synthesis / lipase / Katsuki-Sharpless reaction / enantiocomplementary resolution / enantioconvergent resolution / キラル3‐ヒドロキシアセチレン / キラル4‐ヒドロキシアセチレン / アシル化不斉分割 / 脱アシル化不斉分割 / エナンチオ相補分割 / エナンチオ集約分割 / 光延反応 / キラルαーヒドロキシアセチレン / キラルβーヒドロキシアセチレン / フィト-ル / ビタミンE / ワライタケ成分 / ニコラス反応 / コンパクチンラクトン / マイシノリド / キラルー3ーヒドロキシアセチレン / キラル4ーヒドロキシアセチレン / 香月、ーシャ-プレス反応 / キラルοーベンジルグリシド-ル / メバロン酸ラクトン / コンパクチン |
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| Research Abstract |
Some chiral acetylene building blocks having hydroxy functionality on alpha- or beta-stereogenic center have been prepared in efficient manners involving enzymatic reaction using lipase and asymmetric reaction employing the Katsuki-Sharpless asymmetric epoxidation reaction.
Versatile utility of these acetylene derivatives as chiral building blocks has been demonstrated by transforming these into a wide variety of natural product ranging from simple monoterpenoids to complex natural products, such as alkaloids, aminoacids, and poly ketides in enantiocontrolled ways as well as by devising specific reactions making use of these chiral acetylene compounds.
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