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Evaluation of Abailable Energy of Non-Digestible Oligosaccharides

Research Project

Project/Area Number 02454126
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionUniversity of Tokyo

Principal Investigator

OKU Tsuneyuki  Tokyo University, Department of Nutrition, Assistant Professor, 医学部(医), 講師 (50010096)

Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsnondigestible oligosaccharide / sugar substitute / fermentation / intestinal microflora / available energy / malititol / erythritol / Neosugar / オリゴ糖 / 消化吸収 / エリスリト-トル
Research Abstract

The final purpose of this study is to evaluate the available energy of bulking sugar substitutes which are not hydrolyzed by digestive enzymes and fermented by intestinal microbes in the lower intestine. The available energy of non-digestible and fermentable oligosaccharides could not be estimated by the traditional methods. Because, it is disregarded that short chain fatty acid which is produced from nondigestible sugar substitutes by intestinal microbes, contributes to the host as energy source. However, the experiments using Neosugar demonstrated clearly that oligosaccharide which is not hydrolyzed by digestive enzymes, reaches to the large intestine and is fermented completely by intestinal microbes (Oku et al. J. Nutr., 114 & 119).
This study advocated the new method which estimates the available energy on the basis of fermentation equation. The details of method is described in elsewhere (1, 2, 3, 4). In order to estimate the available energy on the basis of fermentation equation, … More the digestion, absorption, fermentation, excretion and metabolic pathway of the test substance have to be clarified. In this study, Neosugar, maltitol and erythritol which the metabolic property are greatly different each other, were used.
The metabolism of Neosugar has been already investigated. The outline of metabolism of maltitol has also been studied. This study demonstrated that about 10% of total maltitol ingested was digested and absorbed and about 90% of the total was fermented in the large intestine (4, 5). Further, intestinal bacteria which utilizes maltiol, is different from that for Neosugar and maltitol appears to be utilized by yeast and fungi (4). Maltiol was not hydrolyzed by enzymes of large intestinal musosa.
Tetrose alcohol erythritol was readily absorbed from small intestine and excreted quickly into the urine without any degradation (6, 7, 8). The excretion ratio was about more than 90% of total ingestion (6, 7). In the administration of very large amount, the urinary excretion of erythritol decreased and the ratio of fermentation increased (7). The available energy of erythritol was the lowest in reduced-energy sugar substitutes (7, 8). Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Tsuneyuki Oku: "Metabolic fate of ingested ( ^<14>C)-maltitol in man." Journal of Nutritional Science and Vitaminology. 37. 528-544 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tsuneyuki Oku: "Influence of chronlc ingestion of newly developed sweetener,erythritol on growth and gastrointestinal function of the rats." Nutrition Research. 10. 987-996 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kyoji Noda: "Metabolism and disposition of a new sweetener erythritol after oral administration in rats." Journal Nutrition. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 奥 恒行: "新しいタイプの糖質の消化・発酵・吸収とその機能性" 科学と工業. 65. 275-283 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tsuneyuki Oku: "Obesity:Dietary Factors and Control 〔Caloric evaluation of rerduced-energy bulking sweeteners (pp.169-180)〕" eds.Romsos,D.R.et.Japan Sci.Soc.Press,Tokyo/S.Karger,Basel, 272 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tsuneyuki Oku: "Proceeding of WHO symposium on Plants and Health for All 〔Dietary fiber and new sugars〕" eds.Shigeaki Baba et al.Elsevier,Netherlands, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tsuneyuki Oku: "Caloric Evaluationof Carbohydrates 〔Evaluation of bioavailable energy of maltitol (pp.109-123)〕" ed.Norimasa Hosoya Research Foundation for Sugar Metabolism,Tokyo., 257 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tuneyuki Oku: "Caloric Evaluationof carbohydrates 〔Erythritol balance study and estimation of metabolizabl energy of erythritol (pp.65-75)〕" ed.Norimasa Hosoya,Research Foundation for Sugaqr Metabolism,Tokyo, 257 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T.: "Caloric Evaluation of Reduced-Energy Bulking Sweeteners." In Obesity : Dietary Factors and Control. Japan Sci. Soc. Press. 169-180 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T.: "Dietary Fiber and New Sugars." In Proc. of WHO Symp. on Plants and Health for All. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T.: "Digestion, Fermentation, Absorption and Metabolism of Newly Developed Sugar Substitutes and Their Physiological Function." Kagaku to Kogyou. 65. 275-283 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T.: "Evaluation of Bioavailable Energy of Maltitol." Proc. Inter. Symp. on Caloric Evaluation of Carbohydrates. Research Foundation for Sugar Metabolism. 109-123 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T., Akiba, M., Lee, M. H., Moon, S. J. and Hosoya, N.: "Metabolic Fate of Ingested [ ^<14>C]-Maltitol in Man." J. Nutr. Sci. Vitaminol. 37. 529-544 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T. and Noda, K.: "Influence of Chronic Ingestion of Newly Developed Sweetener, Erythritol on Growth and Gastrointestinal Function of the Rats." Nutr. Res.,. 10. 987-996 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Noda, K. and Oku, T.: "Metabolism and Disposition of a New Sweetener Erythritol After Oral administration in Rats." J. Nutr.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Oku, T. and Noda, K.: "Erythritol Balance Study and Estimation of Metabolizable Energy of Erythritol." Proc. Inter. Symp. on Caloric Evaluation of Carbohydrates. Research Foundation for Sugar Metabolism. 65-75 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tsuneyuki Oku: "Metabolic fate of ingested〔^<14>C〕ーmaltitol in man." Journal of Nutritional Science and Vitaminology. 37. 528-544 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tsuneyuki Oku: "Influence of chronic ingestion of newly devloped sweetener,erythritol on growth and gastrointestinal function of the rats." Nutrition Research. 10. 987-996 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 奥 恒行: "新しいタイプの糖質の消化・発酵・吸収とその機能性" 科学と工業. 65. 275-283 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tsuneyuki Oku: "Obesity:Dietary Factors and Control〔Caloric evaluation of rerducedーenergy bulking sweeteners(pp.169ー108)〕" etds.Romsos.D.R.et.Japan Scl.Soc.Press,Tokyo/S.Karger,Basel, 272 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tsuneyuki Oku: "Proceeding of WHO symposium on Plants and Health for All〔Dietary fiber and new sugars〕" eds.Shigeaki Baba et al.Elsevier.Netherlands, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tsuneyuki Oku: "Caloric Evaluation of Carbohydrates〔Evaluation of bioavailable energy of maltitol(pp.109ー123)〕" ed.Norimasa Hosoya Research Foundation for Sugar Metabolism,Tokyo., 257 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kyouji NODA: "Metabolism and Disposition of New Sweetener Erythritol" Journal of Nutrition. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tsuneyuki OKU: "「Caloric Evaluation of Carbohydrates」Evaluation of Bioavailable Energy of Maltitol" Research Foundation for Sugar Metabolism, 200 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tsuneyuki OKU: "「Diet and Obesity」Caloric Evaluation of Reduced Energy Bulking Sweeteners" Masasige Suzuki,Dale R.Romsos, 240 (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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