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Genetically obese animal : Defect in brain histamine control of adaptative function

Research Project

Project/Area Number 02454129
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionOITA MEDICAL UNIVERSITY (1991-1992)
Kyushu University (1990)

Principal Investigator

SAKATA Oosiie  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE PROFESSOR, 医学部, 教授 (50037420)

Co-Investigator(Kenkyū-buntansha) KIMURA Akinori  KYUSYU UNIVERSITY FACULTY OF MEDICINE ASSOCIATE PROFESSOR, 医学部, 助教授 (60161551)
YOSHIMATSU Hironobu  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 助手 (00166993)
SATO Yasufumi  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE ASSISTANT PROFESSOR, 医学部, 助手 (50178779)
KOHNO Kimitoshi  OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE ASSOCIATE PROFESSOR, 医学部, 助教授 (00153479)
大和谷 厚  大阪大学, 医学部, 助教授 (30116123)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1991: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordszucker obese rat / Histidine decarboxylase / alpha-fluoromethylhistidine / Hypothalamic histamine / Adaptive behavior / Thermoregulation / Genetic obesity / Energy metabolism / α-flnoromethylhistidine / 三叉神経中脳路核 / インターロイキン1-β / 視床下部グリコーゲン / 視床下部神経ヒスタミン代謝回転 / ヒスチジン脱炭酸酵素のmRNA発現量 / αーfluoromethylhistidine / 摂食の明暗周期消失 / 高温環境への適応行動 / 体温の恒常性維持 / 2ーdeoxyーDーglucoseによる遅発性摂食抑制 / Zuckerラット / ヒスタミン不応性 / 肥満 / 摂食行動 / 概日リズム / αーフルオロメチルヒスチジン
Research Abstract

Genetically obese Zucker rats have been shown to have abnormalities in regulation of adaptive behavior, body temperature and metabolism. Present study aims to clarify whether impairment of histaminergic system in the hypothalamus may cause these regulatory dysfunctions.
Results : 1) Obese Zuckers had defect in behavioral responses to manipulation of gypothalamic neuronal histamine. 2) Concentration of neuronal histamine was hardly detectable in the obese Zucker hypothalamus. The defect in neuronal histamine of the obese Zuckers was resulted from inactivity of histamine synthesizing enzyme, histidine decarboxylase (HDC), compared to that of lean littermates and wistar King A rats. 3)Obese rats showed abnormal feeding behavior including dysruption of circadian rhythm, increase in size and duration of a meal, decrease in eating speed, and dysfunction of mastication.
The abnormalities mimiced those of the Wistar King A rats, from which neuronal histamine was depleted by use of alpha-fluorome … More thylhistidine (FMH), a suicide inhibitor of HDC.4)Energy deficiency due to starvation, insulin-induced hypoglycemia, and intracellular glucoprivation induced by 2-deoxy-D-glucose activated histaminergic system in the hypothalamus. 5) The activation of histaminergic system induced glycogenolysis in the hypothalamus, which resulted in homeostatic maintenance of energy supply. 6)Obese Zuckers failed to regulate energy metabolism under glucoprivic condition controled by histaminergic system. 7)Both obese Zuckers and histamine-depleted rats showed distorted adaptive behavior for high ambient temperature. 7)Abnormalitiy of HDC gene could not be demonstrated by molecular biology, but its genetic rearrangement such as point mutation was highly probable.
These results indicate that dysfunction of histaminergic system in the hypothalamus may cause abnormalities of Zucker obese rats, because hypothalamic neuronal histamine has been found to be crucial for integration of homeostatic energy metabolism. Less

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (71 results)

All Other

All Publications (71 results)

  • [Publications] T.Sakata: "Peeding modulation by pentose and hexose analogues^<1-3>." Am.J.Clin.Nutr. 55. 272S-277S (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Sakata: "Histaminengic control of energy balance in rats." Brain Res.Bull. 27. 371-375 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yoshimatsu: "Abnormalities in obese Zuckers:Defective control of histaminergic functions." Physiol.Behav.54. 487-491 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Kang: "Aminoglucose-induced feeding suppression is regulated by hypothalamicneuronal histamine in rats." Brain Res. 631. 181-186

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] A.Oohara: "Neuronal glucoprivation modulates hypothalamic histamineturnover in rats." J.Neurochem.in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Doi: "Hypothalamic neuronal histamine regulates feeding circadian rhythm in rats." Brain Res.in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates ingestive and adaptive behavior,and thermoregulation in rats." Advances in Physiological Sciences, 8 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto, K., Sakata, T., Ookuma, K., Kurokawa, M., Yamatodani, A., Wada, H.: "Hypothalamic histamine modulates adaptive behavior of rats in high environmental temperature" Experientia. 46. 283-285 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ookuma, K., Sakata, T., Fujimoto, K.: "Evidence for feeding elicited through antihistaminergic effects of tricyclic antidepressants in the rat hypothalamus." Psychopharmacology. 101. 481-485 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sagata, T., Fukagawa, K., Ookuma, K., Fujimoto, K., Yoshimatsu, H., Yamatodani, A., Wada, H.: "Hypothalamic neuronal histamine modulates an libitum feeding by rats." Brain Res.537. 303-306 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T., Fukagawa, K.: "Implications of hypothalamic histamine H_1-receptors in food intake." Syst.REs.Physiol.5(suppl.1). 25-28 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T.: "Structural and stereoisomeric specificity of serum-borne sugar acids related to feeding control by rats." Brain Res.Bull.25. 969-974 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kurokawa, M., Sakata, T., Yoshimatsu, H., Machidori, H.: "2,5-Anhydro-D-mannitol : Its unique central action on food intake and blood glucose in rats" Brain Res.566. 270-275 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T.: "Newly Detected Endogenous Substances : their Physiological Implications on Food Intake." Agressologie. 32. 15-19 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T., Ookuma, K., Fujimoto, K., Fukugawa, K., Yoshimatsu, H.: "Histaminergic control of energy balance in rats." Brain Res.Bull. 27. 371-375 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto, K., Imamura, I., Granger, D.N., Wada, H., Sakata, T., Tso, O.: "Histamine and histidine decarboxylase are correlated with mucosal repair in rat small intestine after ischemia-reperfusion." J.Clin.Invest.89. 126-133 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimatsu, H., Sakata, T.: "Histaminergic modulation of feeding behavior." Progress in Obesity Research 1990, Eds by Y.Oomura, S.Tarui, S.Inoue and Y.Shimazu. 1991. Hohn Libbey. 29-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kurokawa, M., Sakata, T., Yoshimatsu, H., Machidori, H.: "Biphasic feeding modulation induced induced by central infusion of 2,5-anhydro-D-mannitol in rats." Progress in Obesity Research 1990, Eds by Y.Oomura, S.Tarui, S.Inoue and T.Shimazu. 1991. John Libbey. 33-36

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Arase, K., Sakata, T.: "Correction of distorted congnitive control of eating behavior in moderately obese patients." Progress in Obesity Research 1990, Eds by Y.Oomura, S.Tarui, S.Inoue and T.Shimazu. 1991. John Libbey. 537-540

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T.: "Feeding behavior." Histaminergic Neurons : Morphology and Function, Eds by T.Watanabe and H.Wada 1991, CRC press, Boca Raton. 297-313

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T.: "Hypothalamic neuronal histamine modulates energy balance in rats." New Perspectives in Histamine Research, Eds by H.Timmerman and H.van der Goot, 1991. Birkhauser Verlag, Basel.91-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T.: "Central mechanism of ginsenoside Rg_1 in modulation of rat energy balance." Recent advance in biochemistry : Chapter V, Natural Products. Eds. by S.M.Byun, S.Y.Lee, C.H.Yang. 1991, Korea. 573-581

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto, K., Sakata, T., Etou, H., Fukagawa, K., Ookuma, K., Terada, K., Kurata, k.: "Charting of daily weight pattern reinfoces maintenance of weight reduction in moderately obese patients." Am.J.Med.Sci.303. 145-150 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimatsu, H., Sakata, T., Machidori, H., Ookuma, K., Doi, T.: "Acceleration of tail-pinch-induced feeding in rats by analgesic" Physiol.Behav.51. 1243-1246 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Okabe, Y., Sakata, T., Kurokawa, M., Fujimoto, K., Ueda, K., Masuno, H., Okuda, H.: "Anorexia induced by toxohormone-L isolated from ascites fluid of patients with hepatoma." Physiol.Behav.52. 333-337 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto, K., Granger, D.N., Johnson, L.R., Price, V.H., Sakata, T., Tso, P.: "Circadian rhythm of ornithine decarboxylase activity in small intestine of fasted rats." Proc.Soc.Exp.Biol.Med.200. 409-413 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Machidori, H., Sakata, T., Yoshimatsu, H., Ookuma, K., Fujimoto, K., Kurokawa, M., Yamatodani, A., Wada, H.: "Zucker obese rats : Defect in brain histamine control of feeding." Brain Res.570. 180-186 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fukagawa, K., Sakata, T., Yoshimatsu, H., Fujimoto, K., Uchimura, K., Asano, C.: "Advance shift of feeding circadian rhythm induced by obesity progression in Zucker rats." Am.J.Physiol.263. R1169-R1175 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T., Kurokawa, M.: "Feeding modulation by pentose and hexose analogues." Am.J.Clin.Nutr.55. 272s277s (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakata, T., Yoshimatsu, H.: "Hypothalamic neuronal histamine modulates ingestive and adaptive behavior, and thermoregulation in rats." Advances in Physiological Sciences : Eds. by S.K.Manchanda, W.Selvamurthy, V.Mohan Kumar. 1992, Macmillan, Delhi. 665-672

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimatsu, H., Sakata, T., Machidori, H., fujimoto, K., Yamatodani, A., Wada, H.: "Ginsenoside Rg_1 prevents histaminergic modulation of rat adaptive behavior from elevation of ambient temperature." Physiol.Behav.53. 1-4 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto, K., Fukagawa, K., Sakata, T., Tso, P.: "Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats." J.Clin.Invest .91. 1830-1833 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto, K., Machidori, H., Iwakiri, R., Yamamoto, K., Fujisaki, J., Sakata, T., Tso, P.: "Effect of intravenous administration of apolipoprotein A-IV on patterns of feeding, drinking and ambulatory activity of rats." Brain Res.603. 233-237 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujisaki, J., Fujimoto, K., Oohara, A., Sakata, T., Hirano, M., Ohyama, T., Iwakiri, R., Yamaguchi, M.: "Role of histamine and diamine oxidase in mucosa of rat small intestine after ischemia-reperfusion." Dig.Dis.Sci.38. 1195-1200 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujise, T., Yoshimatsu, H., Kurokawa, M., Fukagawa, K., Nakata, N., Sakata, T.: "Food consistency modulates eating volume and speed through brain histamine in rat." Brain Res.Bull.32. 555-559 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimatsu, H., Machidori, H., Doi, T., Kurokawa, M., Ookuma, K., Kang, M., Fujimoto, K., Sakata, T.: "Abnormalities in obese Zuckers : Defective control of histaminergic functions." Physiol.Behav.54. 487-491 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ookuma, K., Sakata, T., Fukagawa, K., Yoshimatsu, H., Fujimoto, K., Kurokawa, M., Machidori, H., Yamatodani, A., Wada, H.: "Neuronal histamine in the hypothalamus suppresses food intake in rats." Brain Res.628. 235-242 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kang, M., Yoshimatsu, H., Kurokawa, M., Oohara, A., Sakata, T.: "Aminoglucose-induced feeding suppression is regulated by hypothalamic neuronal histamine in rats." Brain Res.631. 181-186 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tanaka, T., Fujimoto, K., Sakata, T., Fujimoto, T., Tsunada, S., Iwakiri, R., Yamaguchi, M., Okabe, Y., Yoshimatsu, H.: "Effect of vagotomy on ornithine decarboxylase activity in rat duodenal mucosa." Am.J.Physiol.265. G1016-G1020 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Oohara, A., Yoshimatsu, H., Kurokawa, M., Oishi, R., Saeki, K., Sakata, T.: "Neuronal glucoprivation modulates hypothalamic histamine turnover in rats." J.Neurochem.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Doi.T., Sakata, T., Yoshimatsu, H., Machidori, H., Kurokawa, M., Jayasekara, L.A.L.W., Niki, N.: "Hypothalamic neuronal histamine regulates feeding circadian rhythm in rats." Brain Res.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Sakata: "Feeding modulation by pentose and hexose analogues^<1-3>." Am.J.Clin.Nutr.55. 272S-277S (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Sakata: "Histaminergic control of energy balance in rats." Brain Res.Bull. 27. 371-375 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Machidori: "Zucker obese rats:Defect in brain histamine control of feeding." Brain Res.590. 180-186 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Yoshimatsu: "Acceleration of tail-pinch-induced feeding in rats by analgesic effect of neurotropin in rats." Physiol.Behav.51. 1243-1246 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Fujimoto: "Histamine and histidine decarboxylase are correlatid with mucosal repair in rats small intestine after ischemia-reperfusion." J.Clin.Invest.89. 126-133 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A.Oohara: "Neuronal glucoprivation modulates hypothalamic histamine turnover in rats." J.Neurochem.

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates energy balance in rats." New Perspectives in Histamine Research., 6 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates ingestive and adaptive behavior,and thermoregulation in rats." Advances in Physiological Sciences, 8 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates libitum feeding by rats." Brain Res.537. 303-306 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Implications of hypothalamic histamine H_1ーreceptors in food intake." Syst.Res.Physiol.5(Suppl.1). 25-28 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Kurokawa: "2,5ーAnhydroーDーmannitol: its unique central action of food intake and blood glucose in rats." Brain.Res.566. 270-275 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Machidori: "Zucker obese rats: Defect in brain histamine control of feeding." Brain Res.

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Ookuma: "Neuronal histamine in the hypothalamus suppresses food intake in rats." Am.J.Physiol.

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Fujimoto: "Histamine and histidine decarboxylase are correlated with mucosal repair in rat small intestine after ischemiareperfusion." J.Clin.Invest.89. 126-133 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Structural and steroisomeric specificity of serumーborne sugar acids related to feeding control by rats." Brain Res.Bull.25. 969-974 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Feeding modulation by pentose and hexose analogues." Am.J.Clin.Nutr.55. 272S-277S (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Histaminergic control of energy balance in rats." Brain Res.Bull.27. 371-375 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates ingestive and adaptive behavior,and thermoregulation in rats." Proceeding of the 2nd AOPS,.

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Feeding Behaviour" Histaminergic Neurons:Morphology and Function., 17 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates energy balance in rats." New Perspectives in Histamine Research., 6 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yoshimatsu: "Histaminergic modulation of feeding behavior." Progress in Obesity Research 1990, 4 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "THe FIRST BRATANOV MEMORIAL LECTURE: Newly d etectedendogenous substances,their physiological implications of food intake." Oligopeptides in the Mechanism of Emotional Reactions, 13 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Sakata: "Hypothalamic neuronal histamine modulates ad libitum feeding by rats." Brain Res.537. 303-306 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Structural and stereoisomeric specificity of serumーborne Sugar acids related to feeding control by rats." Brain Res.Bull.25. 969-974 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Implications of hypothalamic histamine H_1ーreceptors in food intake." Syst.Res.Physiol.5(Suppl.1). 25-28 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Differences in feeding modulation by pentose and hexose analogues." Am.J.Clin.Nutr.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Histaminergic control of energy balance in rats." Brain Res.Bull.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Central mechanism of ginsenoside Rg_1 in modulation of rat energy balance." Proceedings of New Perspectives in Histamine Research. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Feeding Behaviour.IN:Histaminergic Neurons:Morphology and Function,Ed.by T.Watanabe." CRC Press,New York., (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Sakata: "Central mechanism of ginsenoside Rg_1 in modulation of rat energy balance.IN:Recent Advances in Biochemistry:Chapter V.Natural Products.Ed.by S.S.Lee." Plenum,New York., (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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