| Project/Area Number |
02454187
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
MURAMATSU Shigeru Kyoto Univ., Fac. of Science, Professor, 理学部, 教授 (30025291)
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| Co-Investigator(Kenkyū-buntansha) |
INABA Kayo Kyoto Univ., Fac. of Science, Instructor, 理学部, 助手 (00115792)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1990: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | Hypothalamic hormones / Pituitary hormones / Opioid peptides / Interferons / Macrophages / Lymphocytes / Immune responses / マクロファ-ゼ / 甲状腺刺激ホルモン / 甲状腺刺激ホルモン放出ホルモン / 免疫寛容 / リンパ球増殖 |
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| Research Abstract |
We investigated the effects of hypothalamic hormones, and also those of some pituitary hormones and opioid peptides, on the activity of immune-related cells, such as macrophages, natural killer cells, and lymphocytes.
Main results obtained are as follows : 1) Corticotropin-releasing hormone (CRH) and opioid peptides enhanced the antitumor activity of macrophages latently activated by low concentrations of interferon (IFN) -gamma and bacterial lipopolysaccharide. Naloxone, an antagonist of opioids, abrogated the effect of opioid peptides, but not that of CRH ; 2) CRH and opioid peptides enhanced thd production of IFN-gamma and IFN-alpha by human monocutes and lymphocytes. Corticotropin (ACTH) and a glucocorticoid (dexamethasone) inhibit the IFN production : 3) Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) augmented the lectin-induced proliferation of T and B cells ; and 4) TRH did not affect the in vivo antibody response, but interrupted the tolerance induction in mouse by deaggregated human gamma globulin. We are studying the effect of many other hormones on various immune responses, but concrete results we obtained are still very few. Investigations are underway. Accumulation of phenomenological results, analysis for them, and logical construction will be required for understanding the biological importance of the psycho-neuro-endocrino-immune network.
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