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Regulation of immune responses by hypothalamic hormones

Research Project

Project/Area Number 02454187
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

MURAMATSU Shigeru  Kyoto Univ., Fac. of Science, Professor, 理学部, 教授 (30025291)

Co-Investigator(Kenkyū-buntansha) INABA Kayo  Kyoto Univ., Fac. of Science, Instructor, 理学部, 助手 (00115792)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1990: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsHypothalamic hormones / Pituitary hormones / Opioid peptides / Interferons / Macrophages / Lymphocytes / Immune responses / マクロファ-ゼ / 甲状腺刺激ホルモン / 甲状腺刺激ホルモン放出ホルモン / 免疫寛容 / リンパ球増殖
Research Abstract

We investigated the effects of hypothalamic hormones, and also those of some pituitary hormones and opioid peptides, on the activity of immune-related cells, such as macrophages, natural killer cells, and lymphocytes.
Main results obtained are as follows : 1) Corticotropin-releasing hormone (CRH) and opioid peptides enhanced the antitumor activity of macrophages latently activated by low concentrations of interferon (IFN) -gamma and bacterial lipopolysaccharide. Naloxone, an antagonist of opioids, abrogated the effect of opioid peptides, but not that of CRH ; 2) CRH and opioid peptides enhanced thd production of IFN-gamma and IFN-alpha by human monocutes and lymphocytes. Corticotropin (ACTH) and a glucocorticoid (dexamethasone) inhibit the IFN production : 3) Thyrotropin-releasing hormone (TRH) and thyrotropin (TSH) augmented the lectin-induced proliferation of T and B cells ; and 4) TRH did not affect the in vivo antibody response, but interrupted the tolerance induction in mouse by deaggregated human gamma globulin. We are studying the effect of many other hormones on various immune responses, but concrete results we obtained are still very few. Investigations are underway. Accumulation of phenomenological results, analysis for them, and logical construction will be required for understanding the biological importance of the psycho-neuro-endocrino-immune network.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Takema,M.: "Macrophage-activating factor extracted from mycoplasmas." Cancer Immunol.Immunother.33. 39-44 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Muramatsu,S.: "Hormones as cytokines in the immune system." Biomed.Gerontol.16. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Deguchi,M.: "Effect of thyrotropin-releasing hormone on the lectin-induced proliferation of murine lymphocytes and on the induction of immunological tolerance."

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hagi,K.: "Effects of beta-endorphin,corticotropin and corticotropin-releasing hormone on the antitumor activity of macrophages."

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Uno,K.: "Effects of stress-related hormones on the production of IFN-alpha and IFN-gamma in human lymphocytes and monocytes."

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takema, M.: "Macrophage-activating factor extracted from mycoplasmas." Cancer Immunol. Immunother.33. 39-44 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Muramatsu, S.: "Hormones as cytokines in the immune system." Biomed. Gerontol.16. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Deguchi, M.: "Effect of thyrotropin-releasing hormone on the lectin-induced proliferation of murine lymphocytes and on the induction of immunological tolerance."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hagi, K.: "Effects of beta-endorphin, corticotropin and corticotropin-releasing hormone on the antitumor activity of macrophages."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Uno, K.: "Effects of stress-related hormones on the production of IFN-alpha and IFN-gamma in human lymphocytes and monocytes."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takema,M.: "Macrophageーactivating factor extracted from mycoplasmas." Cancer Immunol.Immunother.33. 39-44 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Muramatsu,S.: "Hormones as cytokines in the immune system." Biomed.Gerontol.16. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Deguchi,M.: "Effect of thyrotropinーreleasing hormone on the lectinーinduced proliferation of murine lymphocytes and on the induction of immunological tolerance." Manuscript.

    • Related Report
      1991 Annual Research Report
  • [Publications] Hagi,K.: "Effects of betaーendorphin,corticotropin and corticotropinーreleasing hormone on the antitumor activity of macrophages." Manuscript.

    • Related Report
      1991 Annual Research Report
  • [Publications] Uno,K.: "Effects of stressーrelated hormones on the production of IFNーalpha and IFNーgamma in human lymphocytes and monocytes." Manuscript.

    • Related Report
      1991 Annual Research Report
  • [Publications] Muramatsu,S.,Inaba,K.(Inaba,M.): "Functional analyses of thymic CD5_+ B cells.Responsiveness to major histocompatibility complex class IIーrestricted T blasts but not lipopolysaccharide or antiーIgM plus interleukin 4." J.Exp.Med.171. 321-326 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Muramatsu,S.,Inaba,K.(Inaba,M.): "Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells." J.Exp.Med.173. 549-559 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Muramatsu,S.,Inaba,K.(Inaba,M.): "Effect of Lーarginine on the retention of macrophage tumoricidal activity." J.Immunol.146. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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