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Study in essential and poisoning amounts of trace element for human

Research Project

Project/Area Number 02454201
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionKyoto University

Principal Investigator

KIMURA M.  Fac. of Medicine Assoc. Professor, 医学部, 助教授 (60025658)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA M.  Fac. of Medicine Assoc. Professor, 医学部, 助教授 (20115786)
YOKOI K.  Fac. of Medicine Instructor, 医学部, 助手 (10200883)
ITOKAWA Y.  Fac. of Medicine Professor, 医学部, 教授 (80025593)
近藤 久雄  京都大学, 医学部, 助手 (20205561)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥6,300,000 (Direct Cost: ¥6,300,000)
Keywordstrace element / essential amount / poisoning amount / minerl unbalance / 微量元素相互 / 微量元素栄養アセスメント法 / 微量元素栄養状態 / 微量元素必要量 / 微量元素中毒量 / 微量元素相互作用 / セレン定量法 / 錫定量法 / 必要量 / 中毒量
Research Abstract

Recently it has been reported that the unbalances of food habits and parenteral nutrition etc. induces essential trace elements deficiencies. To clarify essential amounts, toxic amounts and also physiological actions of essential trace elements (zine. copper. manganese. selenium. tin. germanium), the following researchs were studied.
(1) To clarify essential amounts of trace elements for Japanese, trace elements intake were calculated or determined from the results of food survey or determination of trace element amounts in one day foods.
(2) New high-sensitive determination methods of trace elements (selenium. tin. germanium, etc.) in biological samples were established.
(3) New high-sensitive determination method of metallothionein in biological samples by high-performance liquid chromatography were established.
(4) Trace elements deficiencies or over dose intake induced unbalances of other nutrient status, especially, mineral status. For examples, iron deficiency induced other mineral unbalanced, copper deficiency induced iron deficiency, protein deficiency enforced selenium deficiency and rats fed over dose germanium decreased serum potassium concentration and increased serum TG or phospholipid concentration, etc. Manganese deficient model rats could be made from mother rat fed manganese deficient diet.
(5) In the patients with parenteral nutrition, trace elements (Zn, Fe. Cu, Mn. I) deficiency were induced. Basal study for the trace element drug of parenteral nutrition was developed.
(6) The method to assess nutritional(Mn)status with lymphocyte was laid.
(7) From the nutrients intake and blood trace elements concentration in Japanese and Thai, relationships between trace elements status and disease or aging were established.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] Z.Zhu,M.Kimura,Y.Itokawa: "Effect of selenuim-protein-deficioncy on selenium and glutatrhione peroxidase in rods." Bio.Tra.Elem.Res.(1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 美恵子,関根 健二,糸川 嘉則: "生体試料中セレニウムの水素化物加熱原子化による高感度定量法" Biomed.Res.Trace Elements. 2. 89-90 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Effect of dietary iron deficiency on growth and mineral status in rats." Bio.Tra.Elem.Res. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Determination of nonheme iron using in ductiuely coupled plasma-atomic emission spectrometory." Bio.Tra.Elem.Res. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "miniature bydride generator system for in ductiuely coupled plasma-atomic emission spectrometry." Fresenius'J.Amal Chem. 336. 423-424 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 美恵子,松田 晃彦,近藤 久雄,氏家 真弓,糸川 嘉則: "マグネシウム欠乏がひき起こすマンガン欠乏症" マグネシウム. 9. 93-99 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] "Inebficren utilization of iron and minerals in magnesium deficent rats.“magnesium,Health and Disease"" 8 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 美恵子: "マグネシウム生体微量元素" 桜井 弘,田中 英彦編集広川書店, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Kimura,K.Nagai,Y.Itokawa: edited,by Y.Itokawa & J.Durlach John Libbey,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. M. Ahmed, M. Kimura, Y. Itokawa: "Iron and zinc status of protein-energy malnutrished rats." Trac Nutir Res -Recent progress on trace element in nutrition. 4. 121-126 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, Y. Itokawa: "Determination of tin in biological samples by gaseous hydride generation-atomic absorption spectrometry" Trac Nutir Res -Recent progress on trace element in nutrition. 4. 133-138 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kimura, S. Nakagawa, M. Matsumoto, N. Saito, Y. Itokawa: "Correlation between blood magnesium and blood calcium iron or thiamin levels. -A survey study in Thailand-" Magnesium Research. 2. 117-118 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kimura, T. Harada, Y. Itokawa: "Iron accumulation in magnesium deficient rats" Magnesium Research. 2. 116-117 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A. Matsuda, M. Kimura, K. Yokoi, H. Kabata, M. Kataoka, M. Sato, Y. Itokawa: "Effects of total parental nutrition (TPN) containing essential trace elements on magnesium-calcium ratio in cardiac tissue of rats" Magnesium Research. 2. 21-22 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Hiraike, M. Kimura, Y. Itokawa: "Magnesium, calcium and other minerals in human placenta" Magnesium Research. 2. 90-91 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. M. Ahmed, M. Kimura, Y. Itokawa: "Disorder of iron metabolism in young rats fed low protein-low energy diets" Nutr Assessment. 6. 100-103 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A. Matsuda, M. Kimura, K. Kataoka, S. Ohkuma, M. Sato, Y. Itokawa: "Quantifying manganese in lympocytes to assess manganese nutritional status" Clin Chem. 35. 1939-1941 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kimura, K. Nagai, Y. Itokawa: "Food habits and magnesium intake of Japanese" Magnesium in Health & Disease Jhon Libby. 63-69 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kimura, Y. Itokawa: "Inefficient utilization of iron and minerals in magnesium deficient rats" Magnesium in Health & Disease Jhon Libby. 95-102 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, Y. Itokawa: "Determination of tin in biological samples using gaseous hydride generation-inductively coupled plasma atomic emission spectrometry." Anal Biochem. 190. 71-77 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, Y. Itokawa: "Effect of dietary tin deficiency on growth and mineral status in rats." Biol Trace Elem Res. 223-231 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, Y. Itokawa: "Miniature hydride generator system for inductively coupled palsma-aomic emission spectrometry" Fresenius' J Anal Chem. 336. 423-424 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Kondo, M. Kimura, Y. Itokawa: "Manganese, copper, zinc, and iron concentrations and subcellular distribution in two types of skeletal muscle" P S E B M. 196. 83-88 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, Y. Itokawa: "Determination of nonheme iron using inductively coupled palsma-atomic emission spectrometry" Biol Trace Elem Res. 31. 265-279 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yokoi, M. Kimura, Y. Itokawa: "Effect of dietary iron deficiency on growth and mineral status in rats." Biol Trace Elem Res. 31. 257-265 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A. Matsuda, M. Kimura, M. Kataoka, S. Ohkuma, M. Sato, Y. Itokawa: "Manganese level in lympocyte for assessment of manganese nutritional status" J Trace Elem Exp Med. 2. 97 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kimura, Y. Itokawa: "Effects of subacute germanium drinking on health status in rats" J Trace Elem Exp Med. 2. 137 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Kimura, Y. Itokawa: "Declined manganese levels associated with magnesium deficiency in rats" J Trace Elem Exp Med. 2. 143 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] J. Kashimura, M. Kimura, H. Kondo, K. Yokoi, K. Nishio, Y. Nakajima, Y. Itokawa: "Effect of palatinose and palatinose condensate feeding on mineral contents of tissues in rats" J Trace Elem Exp Med. 2. 89 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 美恵子,松本 晶博,高岡 篤,原田 夏樹,中川 吾一,翠川 裕,糸川 嘉則: "タイ東北地区住民の血中無機質レベル" 微量栄養素研究. 3. 185-194 (1986)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Kimura,S.Nakagawa,M.Matsumoto,N.Saito,Y.Itokawa: "Correlation between blood masnesium and blood calcium,iron or thiamin levelsーA surver study in Thailandー" Magnesium Res.2. 117-118 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] A.Matsuda,Mikimura,K.Kataoka,S.Ohkuma,M.Sato,Y.Itokawa: "Quantifying manganese in lymphocytes to ass ess mangaese mutritional status" Clin Chem. 35. 1939-1941 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 加畑 寿明,松田 晃彦,桜井 克彦,木村 美恵子,糸川 嘉則: "マンガン投与量、投与経路の違いによるラット胎内マンガン濃度" 日本衛生学雑誌. 44. 667-672 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] Z.Zhu;Mikimura;Y.Itokawa: "Effect of selenuimーprotein deficiency on selenium and glutathione peroxidase in rats." Bio.Tra.Elem.Res.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 美恵子,関根 健二,糸川 嘉則: "生体試料中セレニウムの水素化物加熱原子化による高感度定量法" Biomed.Res.Trace Elemets. 2. 89-90 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Kimura,K.Nagao,Y.Itokawa: "Food babits and magnesium Wtake of Japanese “Magnesium,Heath and pisease"" by Y.Itokawa &,J.Durlach John Libbey, (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 美恵子,桜井 弘,田中 彦編集: "カルシウム生体微量元素" 広川書店, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Kimura,M.Itokawa: "Inefficient utilization of iron and minerals in magnesium deficient rats." Magnesium in Health and Disease. 95-102 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] A.Matsuda,M.Kimura,M.Kabata,S.Ohkuma,M.Sato,Y.Itokawa: "Quantifying manganese in lymphocytes to assess manganese nutriitional status" Clin.Chem.35. 1939-1941 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 美恵子: "マグネシウム欠乏がひき起こすマンガン欠乏症" マグネシウム. 9. 49-59 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 木村 美恵子,横井 克彦,糸川 嘉則: "ラット生体内マグネシウム及びその他ミネラルへのゲルマニウム投子の影響" マグネシウム. 9. 49-59 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Determination of tin in biological samples using gaseous by dride generationーinductively coupled plasmaーatomie cmission spectrometry." Anal.Biochem.190. 71-77 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Yokoi,M.Kimura,Y.Itokawa: "Effect of dietary tin deficiency on growth and mineral status in rats." Biol trace Elem.Res.24. 223-231 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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