Low protein diet, a factor deteriorating toxicities of chemicals
| Project/Area Number |
02454204
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Jichi Medical School |
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Principal Investigator |
NOMIYAMA Kazuo Jichi Medical School Professor, 医学部, 教授 (80048967)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Manabu Jichi Medical School Assistant, 医学部, 助手 (50238333)
NOMIYAMA Hiroko Jichi Medical School Lecturer, 医学部, 講師 (70049039)
中世古 博幸 自治医科大学, 医学部, 助手 (60221446)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1991: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1990: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | low-protein diet / benzene / trichloroethylene / cadmium / lead / mercury / intensified toxicity / hematopoiesis / 感受性 / 毒性増悪 / 腎毒性 |
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| Research Abstract |
1)Intensified benzene toxicity by low-protein diet : Slight decrease in food protein aggravated benzene-induced leucopenia in rats, and significant decrease in food protein deteriorated benzene-induced health effects prominently.
2)Intensified trichloroethylene toxicity by low-protein diet : Slight decrease in food protein worsened trichloroethylene-induced renal dysfunction in rats, and the decrease in food protein by half exacerbated tiicWoroethylene-induced hematopoietic effects as well.
3)Intensified in vitro effects of benzene and trichloroethylene on hematopoiesis by low-protein diet : Hematopoiesis of rats fed low-protein diet were seriously depressed either by benzene or trichloroethylene metabolite in vitro compared with that of rats fed normal diet.
4)Intensified cadmium toxicity by low-protein diet : Slight decrease in food protein worsened cadmium-induced renal dysfunction in rats, and significant decrease in food protein intensified cadmium-induced hepatic dysfunction.
5)Intensified lead toxicity by low-protein diet : The lower the food protein level in rabbits was, the more aggravated lead-induced toxicity in body weight loss, lipid and hemoglobin metabolism abnormalities. Critical protein level to deteriorating cadmium toxicity could not be estimated, however.
6)Intensified mercury toxicity by low-protein diet : The lower the food protein level in rabbits was, the more worsened mercury-induced renal dysfunction and lipid metabolism abnormality were. Critical protein level to deteriorating cadmium toxicity could not be estimated.
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Report
(3 results)
Research Products
(21 results)
