| Project/Area Number |
02454221
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Fukushima Medical College |
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Principal Investigator |
KASUKAWA Reiji Fukushima Medical College, 第二内科, 教授 (80045632)
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| Co-Investigator(Kenkyū-buntansha) |
KANNO Takashi Fukushima Medical College, 第二内科, 助手 (60234168)
MIYATA Masayuki Fukushima Medical College, 第二内科, 助手 (40219788)
NISHIMAKI Tomoe Fukushima Medical College, 第二内科, 助教授 (00128555)
西間木 友樹 福島県立医科大学, 医学部, 助教授
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1990: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Pulmonary hypertension / collagen disease / anti-cardiolipin antibody / von Willebrand factor antigen / anti-nRNP antibody / Monocrotaline-induced rat pulmonary hypertension / cytokine / human endothelial cells / 肺高血圧症 / IL-1 / TNF / IL-6 / 肺胞マクロファージ / 細胞接着 / ラット肺高血圧 / ILー6 / ILー1 / BraU陽性細胞 / プロスタグランディンE_1 / プレドニソロン / シクロホスファミド / 内皮付着細胞 / モノクロタリン肺高血圧症 / CD_8^+11b^+細胞 / 肥満細胞 / Brd U / 右室肥大 |
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| Research Abstract |
1.Pulmonary hypertension with mean pulmonary pressure more than 25mmHg was noted in 10 of 12 patients with collagen disease carrying anti-cardiolipin anti-body but only in 1 of 11 patients with collagen disease not carrying anti-cardiolipin antibody.
2.Serum level of von Willebrand factor antigen was elevated more at 261.8% (mean value) in 5 patients with mixed connective tissue disease (MCTD) associated with pulmonary hypertension (PH) than the level of146.1% in 21 patients with MCTD without PH.
3. Sera of patients with collagen disease carrying anti-nRNP antibody or anti-cardiolipin antibody contained IgG which react to the cultured human endothelial cells.
4. Sera of patients with MCTD carrying anti-nRNP antibody enhanced the adhesion of human T cells to the cultured human endothelial cells.
5. Alveolar macrophage from the monocrotaline-induced pulmonary hypertension rats excreted the increased level of IL-1, IL-6, and TNF in culture supernatant.
6. Human IL-1, 1IL-6, and TNF did not affect the proliferation of the cultured human endothelial cells but enhanced the proliferation of rat pulmonary fibro-blasts.
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